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所長

所長玉照張芳榮教授/榮譽博士 (Prof. / Hon. Dr. Chang, Fang-Rong)

電話:02-2820-1999 轉3101
E-mail:aaronfrc@nricm.edu.tw
 

現職:

衛生福利部  國家中醫藥研究所 所長 2018/02~
高雄醫學大學 天然藥物研究所 教授 2005/08~
國立中山大學 海洋生物科技暨資源學系 合聘教授 2009/08~

學歷:

瑞典烏普薩拉大學 藥學系 榮譽博士 2018
美國北卡羅萊納大學 藥學院 博士後研究 1998 & 2001
日本岡山理科大學 生化學科 博士後研究 2004
高雄醫學大學 藥學研究所 碩士/博士 1990-1995
中山醫學大學 營養學系 學士 1984-1988

經歷:

高雄醫學大學 國際事務處 副國際長 2013~2018
高雄醫學大學 教務處研究生教務組 組長 2012~2013
高雄醫學大學 天然藥物研究所 所長 2006~2012
高雄醫學大學 藥學院 研發組組長 2005~2006
高雄醫學大學 天然藥物研究所 副教授 2002~2005
高雄醫學大學 天然藥物研究所 助理教授 1998~2002
高雄醫學大學 藥學系 講師 1996~1998
高雄醫學大學 藥學系 助教 1994~1996

榮譽:

1995    國科會乙等獎助
1997, 1998, 2000  國科會甲等獎助
1998    中山醫學大學學術類 傑出校友
2004    高雄醫學大學 最佳年輕學者學術研究獎
2006    國科會優秀年輕學者獎助
2012    匈牙利 賽爾格得大學 藥學院金牌獎章
2011    指導科技台灣探索計畫(候鳥計畫)學生自然科學領域第一名
2012    指導學生榮獲國家新創獎學生創新研發獎第一名
2001~  國科會計畫及主持人獎助
2007~  瑞典 Uppsala 大學 Global Pharmacy Courses,  Organizer
2009~  高雄醫學大學傑出研究獎
2009~  高雄醫學大學專利獲證傑出貢獻獎
2009~  高雄醫學大學產學合作傑出績優獎
2010~  國科會獎勵特殊優秀人才
2010~  高雄醫學大學產學推動中心 創新育成中心 輔導顧問
2012~  高雄醫學大學研究績優教師研究計畫績優獎
2012~  高雄醫學大學技術移轉績優獎
2012~  高雄醫學大學研究績優教師優秀論文獎
2015    國立中山大學與高雄醫學大學合作研究優秀學者獎
2015    國立鳳山中學傑出校友
2015    團隊榮獲2015年第12屆國家新創獎
2017    高雄醫學大學 藥學文教基金會學術類傑出校友
2018    瑞典烏普薩拉大學 榮譽藥學博士

 

研究專長:

天然物化學、藥物化學、中草藥及新藥開發、微生物二次代謝物調控

專利與技術轉移:

2007起約有20件

演講:

2013 年迄今超過50場國內外演講

論文發表:

  發表SCI期刊超過320篇研究論文(1991~), 8種國際期刊之編輯委員

  NCBI PubMed : Fang-Rong Chang (Please click!!)

  2016-2017發表論文如下 (39)

  1. Chih-Chuang Liaw, Jing-Ru Liou, Tung-Ying Wu, Fang-Rong Chang, and Yang-Chang Wu, 2016. “Acetogenins from Annonaceae.” Prog. Chem. Org. Nat. Prod., 101, 113−230. (SCI)
  2. Ching-Chia Li*, Juan-Cheng Yang*, Mei-Chin Lu, Chia-Lin Lee, Chieh-Yu Peng, Wei-Yu Hsu, Yun-Hao Dai, Fang-Rong Chang, Da-Yong Zhang, Wen-Jeng Wu, and Yang-Chang Wu, 2016, “ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer.” Oncotarget, 7, 1947−1959. (SCI)
  3. Amos C. Hung, Chun-Hao Tsai, Ming-Feng Hou, Wen-Lin Chang, Chie-Hong Wang, Yi-Chen Lee, Alice Ko, Stephen Chu-Sung Hu, Fang-Rong Chang, Pei-Wen Hsieh*, and Shyng-Shiou F. Yuan*, 2016. “The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway.” Cancer Lett., 371, 251–261. (SCI)
  4. Yu-Ming Hsu, Tung-Ying Wu, Ying-Chi Du, Mohamed El-Shazly, Ludger Beerhues, Tran Dinh Thang, Hoang Van Luu, Tsong-Long Hwang, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “3-Methyl-4,5-dihydrooxepine, polyoxygenated seco-cyclohexenes and cyclohexenes from Uvaria flexuosa and their anti-inflammatory activity.” Phytochemistry, 122, 184–192. (SCI)
  5. I-Wen Lo, Yuan-Bin Cheng, Yi-Jin Hsieh, Tsong-Long Hwang, Deng-En Shieh, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “Chemical Constituents and LC-profile of Fresh Formosan Lonicera japonica Flower Buds.” Nat. Prod. Commun., 11, 1–4. (SCI)
  6. I-Wen Lo, Yuan-Bin Cheng, Chen-Chang Haung, Tsong-Long Hwang, Chin-Chung Wu, Jing-Ru Liou,Ming-Feng Hou, Shyng-Shiou Yuan, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “Constituents of the Leaves of Pandanus utilis.” Nat. Prod. Commun., 11, 173–176. (SCI)
  7. Ching-Peng Chiu, Shan-Chi Liu, Chih-Hsin Tang, You Chan, Mohamed El-Shazly, Chia-Lin Lee, Ying-Chi Du, Tung-Ying Wu, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “Anti-inflammatory Cerebrosides from Cultivated Cordyceps militaris.” J. Agric. Food Chem., 64, 1540−1548. (SCI)
  8. Sándor B. Ötvös, Chi-Ting Hsieh, Yang-Chang Wu, Jih-Heng Li, Fang-Rong Chang*, and Ferenc Fülöp*, 2016. “Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core.” Molecules, 21, 318. (SCI)
  9. Mohamed El-Shazly, Chi-Jung Tai, Tung-Ying Wu, Dezső Csupor, Judit Hohmann, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “Use, history, and liquid chromatography/mass spectrometry chemical analysis of Aconitum.” J. Food Drug Anal., 24, 29−45. (SCI)
  10. Michal Korinek, Vitthal D. Wagh, I-Wen Lo, Yu-Ming Hsu, Hsue-Yin Hsu, Tsong-Long Hwang, Yang-Chang Wu, Yuan-Bin Cheng, Bing-Hung Chen*, and Fang-Rong Chang*, 2016. “Antiallergic phorbol esters from the seeds of Aquilaria malaccensis.” Int. J. Mol. Sci., 17, 398. (SCI)
  11. Yuan-Bin Cheng, Jin-Ching Lee, I-Wen Lo, Shu-Rong Chen, Hao-Chun Hu, Yu-Hsuan Wu, Yang-Chang Wu*, and Fang-Rong Chang*2016. “Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2.” Bioorg. Med. Chem. Lett., 26, 2344−2348. (SCI)
  12. Naglaa S. Ashmawy, Mohamed L. Ashour, Michael Wink, Mohamed El-Shazly, Fang-Rong Chang, Noha Swilam, Ashraf B. Abdel-Naim, Nahla Ayoub*, 2016.“Polyphenols from Erythrina crista-galli: Structures, Molecular Docking and Phytoestrogenic Activity.” Molecules, 21, 726. (SCI)
  13. Chi-ChenYeh, Kun-TzuLi, Jen-Yang Tang, Hui-RuWang, Jing-RuLiu, Hurng-Wern Huang, Fang-RongChang, Cheng-EnTsai, I-WenLo, Ming-YiiHuang, and Hsueh-WeiChang*, 2016. “Butanol-partitioned extraction from aqueous extract of gracilaria tenuistipitata inhibits cell proliferation of oral cancer cells involving apoptosis and oxidative stress.”DNA Cell Biol., 35(5), 210-216. (SCI)
  14. Yu-Ting Tseng, Cheng-Sheng Chenc, Yuh-Jyh Jongd, Fang-Rong Chang, Yi-Ching Lo*, 2016. “Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy.”Pharmacol Res., 111, 58-75. (SCI)
  15. Jia-Fu Li, Hua Fang, Xia Yan, Fang-Rong Chang, Zhen Wu, Yun-Long Wu*,Ying-Kun Qiu*, 2016. “On-line comprehensive two-dimensional normal-phase liquid chromatography-reversed-phase liquid chromatography for preparative isolation of toad venom.”J Chromatogr A., 1456, 169-75.(SCI)
  16. Orsolya Roza, Ana Martins, Judit Hohmann, Wan-Chun Lai, Jacobus Eloff, Fang-Rong Chang, Dezső Csupor*, 2016. “Flavonoids from cyclopia genistoides and their xanthine oxidase inhibitory activity.”Planta Med., 82(14), 1274-8. (SCI)
  17. Xia Yana, Li-Juan Wang, Zhen Wu, Yun-Long Wu, Xiu-Xiu Liu,Fang-Rong Chang, Mei-Juan Fang*, Ying-Kun Qiu*,2016. “New on-line separation workflow of microbial metabolites via hyphenation of analytical and preparative comprehensive two-dimensional liquid chromatography.”J Chromatogr B., 1033-1034, 1-8. (SCI)
  18. Jin-Ching Lee, Fang-Rong Chang, Shu-Rong Chen, Yu-Hsuan Wu, Hao-Chun Hu, Yang-Chang Wu, Anders Backlund, Yuan-Bin Cheng*, 2016. “Anti-Dengue Virus Constituents from Formosan Zoanthid Palythoa mutuki.”Mar. Drugs., 14(8), 151. (SCI)
  19. Fang-Rong Chang, Shih-Ting Huang, Chih-Chuang Liaw, Ming-Hong Yen, Tsong-Long Hwange, Ching-Yeu Chen, Ming-Feng Hou, Shyng-Shiou Yuan, Yuan-Bin Cheng, Yang-Chang Wu*,2016. “Diterpenes from Grangea maderaspatana.”Phytochemistry., 131, 124-129. (SCI)
  20. Ken-ichi Nakashima, Naohito Abe, Fang-Rong Chang, Makoto Inoue, Masayoshi Oyama*,2016. “Pteleifolols A-E, acetophenone di-C-glycosides and a benzopyran dimer from the leaves of Melicope pteleifolia.”J Nat Med.DOI 10.1007/s11418-016-1035-8. (SCI)
  21. Ching-Ying Kuo, István Zupkó, Fang-Rong Chang, Attila Hunyadi, Chin-Chung Wu, Teng-Song Weng, Hui-Chun Wang*,2016. “Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway.”Toxicol Appl Pharmacol., 311, 99-105. (SCI)
  22. Ching-Peng Chiu, Tsong-Long Hwang, You Chan, Mohamed El-Shazly, Tung-Ying Wu, I-Wen Lo, Yu-Ming Hsu, Kuei-Hung Lai, Ming-Feng Hou, Shyng-Shiou Yuan, Fang-Rong Chang*, Yang-Chang Wu*,2016. “Research and development ofCordycepsin Taiwan.”Food Science and Human Wellness, 5, 177–185. (SCI)
  23. Michal Korineka, Kuan-Ming Chen, Yu-Han Jiang, Mohamed El-Shazly, Joel Stockerd, Chon-Kit Choua, Tsong-Long Hwang, Yang-Chang Wu, Bing-Hung Chen*, Fang-Rong Chang*,2016. “Anti-allergic potential of Typhonium blumei: inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx.” Phytomedicine, 23 (14), 1706–1715. (SCI)
  24. Yu-Ming Hsu, Fang-Rong Chang, I-Wen Lo, Kuei-Hung Lai, Mohamed El-Shazly, Tung-Ying Wu, Ying-Chi Du,Tsong-Long Hwang,Yuan-Bin Cheng*,Yang-Chang Wu*,2016. “Zoanthamine-type alkaloids from the zoanthid Zoanthus kuroshio collected in Taiwan and their effects on inflammation.”J Nat Prod., 79(10), 2674−2680. (SCI)
  25. Tung-Ying Wu, Fang-Rong Chang, Jing-Ru Liou, I-Wen Lo, Tang-Chia Chung,Li-Yao Lee, Ying-Chi Du, Man-Hon Wong, Suh-Hang Hank Juo, Chun-Chen Lee*, Yang-Chang Wu*, 2016. “Rapid hplc quantification approach for detection of active constituents in modern combinatorial formula, San-Huang-Xie-Xin-Tang (SHXXT).”Front. Pharmacol., 7, 374. (SCI)
  26. Barbara Tóth, Erika Liktor-Busa, Norbert Kúsz, Ádám Szappanos, Attila Mándi, Tibor Kurtán, Edit Urbán, Judit Hohmann, Fang-Rong Chang*, and Andrea Vasas*, 2016. “Phenanthrenes from Juncus inflexus with antimicrobial activity against Methicillin-resistant Staphylococcus aureus.”J Nat Prod., 79(11), 2814–2823. (SCI)
  27. Kuei-Hung Lai,Mei-Chin Lu,Ying-Chi Du,Mohamed El-Shazly,Tung-Ying Wu,Yu-Ming Hsu,Astrid Henz,Juan-Cheng Yang, Anders Backlund*,Fang-Rong Chang*, Yang-Chang Wu*,2016. “Cytotoxic Lanostanoids from Poria cocos J Nat Prod., 79(11),2805–2813. (SCI)
  28. Abdel Nasser B. Singab*, Iriny M. Ayoub, Mohamed El-Shazly, Michal Korinek, Tung-Ying Wu, Yuan-Bin Cheng, Fang-Rong Chang, Yang-Chang Wu, 2016. “Shedding the light on Iridaceae: Ethnobotany, phytochemistry and biological activity.”Ind Crops Prod., 92, 308–335. (SCI)
  29. Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms,Fang-Rong Chang*, 2016. “Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa).”J. Food Drug Anal., 25(1), 187−196. (SCI)
  30. Barbara Tóth,Fang-Rong Chang, Tsong-Long Hwang,Ádám Szappanos,Attila Mándi,Attila Hunyadi, Tibor Kurtán, Gusztáv Jakab, Judit Hohmann,and Andrea Vasas*, 2017. “Screening of Luzula species native to the Carpathian Basin for anti-inflammatory activity and bioactivity-guided isolation of compounds from Luzula luzuloides (Lam.) Dandy & Wilmott.”Fitoterapia., 116, 131−138. (SCI)
  31. Kuei-Hung Lai,Mei-Chin Lu,Fang-Rong Chang,Jui-Hsin Su,Mohamed El-Shazly,Ying-Chi Du,Tung-Ying Wu,Yu-Ming Hsu,Anders Backlund, Yang-Chang Wu*2016. “Antileukemic sesterterpenoids from a marine sponge, Luffariella sp.”Planta Med.,81(S 01), S1-S381. (SCI)
  32. Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh*, and Fang-Rong Chang*2017. “6-Paradol and 6-Shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-Paradol reduces blood glucose in high-fat diet-fed mice.”Int. J. Mol. Sci., 18(1), 168. (SCI)
  33. Yung-Fong Tsai, Tzu-Chi Chu, Wen-Yi Chang, Yang-Chang Wu, Fang-Rong Chang, Shun-Chin Yang, Tung-Ying Wu, Yu-Ming Hsu, Chun-Yu Chen, Shih-Hsin Chang, Tsong-Long Hwang*2017. “6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury.”Free Radic Biol Med., 106, 379-392.(SCI)
  34. Chi-Ying Li, I-Wen Lo, Shih-Wei Wang, Tsong-Long Hwang, Yu-Ming Chung, Yuan-Bin Cheng, Sung-Pin Tseng, Yi-Hung Liu, Yu-Ming Hsu, Shu-Rong Chen, Hao-Chun Hu,Fang-Rong Chang*, Yang-Chang Wu*2017. “Novel 11-norbetaenone isolated from an entomopathogenic fungus Lecanicillium antillanum.Bioorg Med Chem Lett., 27(9), 1978-1982.(SCI)
  35. Halima Meriem Issaadi, Yu-Chi Tsai, Fang-Rong Chang, Attila Hunyadi*2017. “Centrifugal partition chromatography in the isolation of minor ecdysteroids from Cyanotis arachnoidea.J Chromatogr B Analyt Technol Biomed Life Sci., 1054, 44-49.(SCI)
  36. Hsiang-Lin Tsai, Chi-Jung Tai, Ching-Wen Huang, Fang-Rong Chang, Jaw-Yuan Wang*2017. “Efficacy of low-molecular-weight fucoidan as a supplemental therapy in metastatic colorectal cancer patients: a double-blind randomized controlled trial.Mar Drugs., 15(4), 122. (SCI)
  37. Balázs Dankó,Szilárd Tóth,Ana Martins,Vágvölgyi Máté,Norbert Kúsz,Joseph Molnár,Fang-Rong Chang,Yang-Chang Wu,Gergely Szakács,Attila Hunyadi*2017. “Synthesis and SAR study of novel anticancer protoflavone derivatives - investigation of cytotoxicity and interaction with the ABCB1 and ABCG2 multidrug efflux transporters.”ChemMedChem.,12(11), 850-859.(SCI)
  38. Vitthal D. Wagh, Michal Korinek, I-Wen Lo, Yu-Ming Hsu, Shu-Li Chen, Hsue-Yin Hsu, Tsong-Long Hwang,Yang-Chang Wu,Bing-Hung Chen*,Yuan-Bin Cheng*, Fang-Rong Chang*2017. “Inflammation modulatory phorbol esters from the seeds of Aquilaria malaccensis.”J. Nat. Prod., 80, 1421−1427.(SCI)
  39. Yuan-Bin Cheng, Hao-Chun Hu, Yu-Chi Tsai, Shu-Li Chen, Mohamed El-Shazly, Maribel G. Nonato, Yang-Chang Wu*Fang-Rong Chang*2017. “Isolation and absolute configuration determination of alkaloids from Pandanus amaryllifolius.Tetrahedron., 73, 3423-3429. (SCI)