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首頁 > 研究單位 > 中藥化學研究組
沈建昌(Shen, Chien-Chang)

沈建昌實驗室生活照姓名: 沈建昌Shen, Chien-Chang) 
職稱: 副研究員 
電話: 2820-19998581、8571
E-mail : ccshen@nricm.edu.tw

學歷:
美國北卡羅萊納大學 化學系 博士
主要經歷
美國俄亥俄州立大學 化學系 博士後研究

專長:
有機化學,藥物設計與合成,天然物化學

研究簡介:
        傳統中藥的使用已有數千年之歷史,經過長期臨床驗證,累積了許多寶貴之知識與經驗。除了典籍上記載的傳統中藥以外,還有許多民間藥物也廣泛地被使用。為了尋求對許多疾病有效的治療方式,目前不僅東方國家積極研究發展中草藥,歐美國家也越來越重視中草藥之研究。本實驗室之研究主要即在於以包括不對稱反應等各種方法合成從中草藥中分離出來具有生物活性之天然物,並進行結構修飾與藥物設計,以探討其結構與活性間之關聯性,尋找出可治療疾病之先導藥物,作為新藥開發之基礎。除此之外,本實驗室亦從事中草藥中天然物之分離與結構鑑定之研究。

期刊論文:

      NCBI PubMed :  Chien-Chang Shen (Please click!!)


  1. Alimboyoguen, A. B., Kathlia, A. D. C.-C., Shen, C.-C., Li, W.-T., & Ragasa, C. Y. (2014). Chemical constituents of the bark of Aleurites moluccana L. Willd. Journal of Chemical & Pharmaceutical Research, 6(5), 1318-1320.
  2. Espineli, D. L., Agoo, E. M. G., Shen, C. C., & Ragasa, C. Y. (2014). Chemical Constituents of Cinnamomum trichophyllum. Chemistry of Natural Compounds, 50(2), 389-390. doi:10.1007/s10600-014-0964-2
  3. Ragasa, C. Y., Torres, O. B., Shen, C. C., Bernardo, L. O., Mandia, E. H., K, A. D. C.-C., & Tsai, P. W. (2014). Chemical Constituents of Ficus linearifolia and Ficus triangularis. Chemistry of Natural Compounds, 50(1), 172-174.  doi:10.1007/s10600-014-0904-1
  4. Espineli, D. L., Agoo, E. M. G., Shen, C. C., & Ragasa, C. Y. (2013). Chemical Constituents of Cinnamomum iners. Chemistry of Natural Compounds, 49(5), 932-933. doi:10.1007/s10600-013-0783-x
  5. Espineli, D. L., Agoo, E. M. G., Shen, C. C., & Ragasa, C. Y. (2013). Chemical Constituents of Cinnamomum utile. Chemistry of Natural Compounds, 49(4), 769-770. doi:10.1007/s10600-013-0738-2
  6. Hsiao, P.-C., Liaw, C.-C., Hwang, S.-Y., Cheng, H.-L., Zhang, L.-J., Shen, C.-C., . . . Kuo, Y.-H. (2013). Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia. Journal of Agricultural and Food Chemistry, 61(12), 2979-2986. doi:10.1021/jf3041116
  7. Li, W.-T., Yeh, T.-K., Song, J.-S., Yang, Y.-N., Chen, T.-W., Lin, C.-H., . . . Chen, C.-T. (2013). BPR0C305, an orally active microtubule-disrupting anticancer agent. Anti-Cancer Drugs, 24(10), 1047-1057. doi:10.1097/CAD.0000000000000014
  8. Lin, P.-C., Shen, C.-C., Liao, C.-K., Jow, G.-M., Chiu, C.-T., Chung, T.-H., & Wu, J.-C. (2013). HYS-32, a novel analogue of combretastatin A-4, enhances connexin43 expression and gap junction intercellular communication in rat astrocytes. Neurochemistry International, 62(6), 881-892. doi:10.1016/j.neuint.2013.02.027
  9. Yu, H.-J., Shen, C.-C., Yi, H.-M., Chen, T.-H., Hsueh, M.-L., Lin, C.-C., & Don, M.-J. (2013). Euphorbiane: A novel triterpenoid with an unprecedented skeleton from Euphorbia tirucalli. Journal of the Chinese Chemical Society, 60(2), 191-194. doi:10.1002/jccs.201200290
  10. Chen, H.-J., Shen, Y.-C., Lin, C.-Y., Tsai, K.-C., Lu, C.-K., Shen, C.-C., & Lin, Y.-L. (2012). Metabolomics study of Buyang Huanwu Tang Decoction in ischemic stroke mice by 1H NMR. Metabolomics, 8(5), 974-984. doi:10.1007/s11306-011-0394-0
  11. Consolacion, Y. R., Dinah, L. E., & Shen, C. C. (2012). A new triterpene from Barringtonia asiatica. Natural Product Research, 26(20), 1869-1875. doi:10.1080/14786419.2011.619187
  12. Kai, L., Shen, C.-C., Lin, C.-F., Li, S.-Y., & Huang, Y.-L. (2012). A Phenolic Derivative and Two Diacetylenes from Symphyotrichum subulatum. Planta Medica, 78(16), 1780-1783. doi:10.1055/s-0032-1315372
  13. Lin, C.-F., Chen, C.-C., Shen, C.-C., Chui, C.-H., & Huang, Y.-L. (2012). Simultaneous Determination of Resveratrol Derivatives in Vitis thunbergii Plant by High Performance Liquid Chromatography. Journal of Food and Drug Analysis, 20(2), 495-500. doi:10.6227/jfda.2012200210
  14. Pai, H.-C., Chang, L.-H., Peng, C.-Y., Chang, Y.-L., Chen, C.-C., Shen, C.-C., . . . Pan, S.-L. (2012). Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway. Journal of Molecular Medicine, 91(3), 347-356. doi:10.1007/s00109-012-0945-5
  15. Shen, C.-C., Cheng, J.-J., Lay, H.-L., Wu, S.-Y., Ni, C.-L., Chen, C.-C., & Teng, C.-M. (2012). Cytotoxic apigenin derivatives from Chrysopogon aciculatis. Journal of Natural Products, 75(2), 198-201. doi:10.1021/np2007796
  16. Shen, C.-C., Hong, K.-Y., Chen, J., Zhang, L.-J., Lin, Z.-H., Huang, H.-T., . . . Kuo, Y.-H. (2012). Antioxidant and anti-nitric oxide components from Quercus glauca. Chemical & Pharmaceutical Bulletin, 60(7), 924-929. doi:10.1248/cpb.c12-00174
  17. Weng, T.C., Shen, C.C., Chiu, Y.T., Lin, Y.L., Huang, Y.T. (2012) Effects of armepavine against hepatic fibrosis induced by thioacetamide in rats. Phytother. Res., 26:344–353.
  18. Chiou, W.-F., Shen, C.-C., & Lin, L.-C. (2011). Anti-inflammatory principles from Balanophora laxiflora. Journal of Food and Drug Analysis, 19(4), 502-508.
  19. Dennis, D. R., Rafael, A. E., Shen, C.-C., & Consolacion, Y. R. (2011). A bioactive sesquiterpene from Bixa orellana. Journal of Natural Medicines, 65(1), 206-211. doi:10.1007/s11418-010-0459-9
  20. Ragasa, C. Y., Espineli, D. L., & Shen, C.-C. (2011). New triterpenes from Barringtonia asiatica. Chemical & Pharmaceutical Bulletin, 59(6), 778-782. doi:10.1248/cpb.59.778
  21. Sonia, D. J., Eunice Alexis, C. C., Montuno, A. S., Shen, C.-C., Dinah, L. E., & Consolacion, Y. R. (2011). Cytotoxic cardenolide and sterols from Calotropis gigantea. Natural Product Communications, 6(6), 803-806.
  22. Chang, J.M., Shen, C.C., Huang, Y.L., Shieh, B.J., Chen, C.C. (2010) Two new glycosides from Leonurus japonicus. J. Asian Nat. Prod. Res., 12:740–744.
  23. Shen, C.C., Wang, Y.H., Chang, T.T., Lin, L.C., Don, M.J., Hou, Y.C., Liou,K.T., Chang, S., Wang, W.Y.,Ko, H.C., and Shen, Y.C. (2007) Anti-inflammatory ergostanes from the basidiomata of Antrodia salmonea.Planta Med., 73, 1208-1213.
  24. Shen, C.C., Shen, Y.C., Wang, Y.H., Lin, L.C., Don, M.J., Liou, K.T., Wang, W.Y., Hou, Y.C., and Chang, T.T.(2006) New Lanostanes and naphthoquinones isolated from Antrodia salmonea and their anti-oxidative burst activity in human leukocytes. Planta Med., 72, 199-203.
  25. Don, M.J., Shen, C.C., Lin, Y.L., Syu, W.J., Ding, Y.H., and Sun, C.M. (2005) Nitrogen-containing compounds from Salvia miltiorrhiza. J. Nat. Prod., 68, 1066-1070.
  26. Syu, W.J., Shen, C.C., Lu, J.J., Lee, G.H., and Sun, C.M. (2004) Antimicrobial and  cytotoxic activities of neolignans from Magnolia officinalis. Chem. Biodivers., 1, 530-538.
  27. Yu, H.J., Sun, C.M., Chen, C.C., Wu, T.C., Wei, C.L., and Shen, C.C.* (2004) Asymmetric synthesis of panaxydol and its stereoisomers. Heterocycles, 62, 857-868.
  28. Chen, C.C., Huang, Y.L., Shiao, Y.J., Huang, R.L., Fu, T.T., and Shen, C.C.* (2003)    Synthesis of antioxidative moscatilin and its bibenzyl derivatives. Chin. Pharm. J., 55, 381-390.
  29. Shen, C.C., Kuo, Y.C., Huang, R.L., Lin, L.C., Don, M.J., Chang, T.T., and Chou, C.J. (2003)New ergostane and lanostane from Antrodia camphorata. J. Chin. Med., 14, 247-258. 8. Shen,C.C., Syu, W.J., Li, S.Y., Lin, C.H., Lee, G.H., and Sun, C.M. (2002) Antimicrobial activities of naphthazarins from Arnebia euchroma. J. Nat. Prod., 65, 1857-1862.
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