姓名：林麗純（Lin, Lie-Chwen）
職稱：研究員兼中藥材發展組組長
電話：2820-1999轉7101、7111
E-mail：lclin@nricm.edu.tw

專長:
天然物化學，分析化學

研究簡介: 
　　在面對現代醫學窘境的同時，求教於自然，已成為一個重要趨勢。天然物具有生物多樣性，與化學多樣性。天然物包含了許多類型的化合物，像是類、生物鹼、類黃酮、牲肽、蛋白質、脂質、碳水化合物、核酸、核苷酸等等諸如此類。在對抗新疾病、或提高醫療效益等研究，天然物的發現常讓人喝采。像是銀杏葉抽提物的增進微血管血流作用、青蒿素的抗瘧作用、紫杉醇的抗癌作用、穿心蓮內酯抗發炎作用、金絲桃素的抗憂鬱症作用等等。以活性引導的方式，進行活性組成研究，為本研究室的研究重點。進行層析實驗以分離純化標的組成、光譜分析以解析確立化學結構、化學修飾以探討活性與結構相關性、製程最佳化探討標的物的量化、及分析條件最適化以利品質管制等研究。

期刊論文: 限所內研究人員(用Email)點選編輯

      NCBI PubMed :  Lie-Chwen Lin (Please click!!)

1. Hou, M.-L., Lin, C.-H., Lin, L.-C., & Tsai, T.-H. (2015). The drug-drug effects of rhein on the pharmacokinetics and pharmacodynamics of clozapine in rat brain extracellular fluid by in vivo microdialysis. Journal of Pharmacology and Experimental Therapeutics, 354(3). doi:10.1124/jpet.115.225763
2. Chiou, C.-T., Hsu, R.-Y., & Lin, L.-C. (2014). Isolation and cytotoxic effect of anthraquinones from Morinda umbellata. Planta Medica, 80(13), 1113-1117. doi:10.1055/s-0034-1382956
3. Ho, J.-K., Huo, T.-I., Lin, L.-C., & Tsai, T.-H. (2014). Pharmacokinetics of ractopamine and its organ distribution in rats. Journal of Agricultural and Food Chemistry, 62(38), 9273-9278. doi:10.1021/jf5026168
4. Hou, M.-L., Chang, L.-W., Lin, C.-H., Lin, L.-C., & Tsai, T.-H. (2014). Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes. Journal of Ethnopharmacology, 155(2), 1291-1299. doi:10.1016/j.jep.2014.07.022
5. Hou, M.-L., Chang, L.-W., Lin, C.-H., Lin, L.-C., & Tsai, T.-H. (2014). Determination of bioactive components in Chinese herbal formulae and pharmacokinetics of rhein in rats by UPLC-MS/MS. Molecules, 19(4), 4058-4075. doi:10.3390/molecules19044058
6. Lu, C.-M., Hou, M.-L., Lin, L.-C., & Tsai, T.-H. (2014). Development of a microdialysis system to monitor lamivudine in blood and liver for the pharmacokinetic application in herbal drug interaction and the gene expression in rats. Journal of Pharmaceutical and Biomedical Analysis, 96, 231-240. doi:10.1016/j.jpba.2014.04.001
7. Lu, C.-M., Lin, L.-C., & Tsai, T.-H. (2014). Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. Molecules, 19(12), 21560-21578. doi:10.3390/molecules191221560
8. Wu, Y.-T., Lin, L.-C., & Tsai, T.-H. (2014). Determination of rhynchophylline and hirsutine in rat plasma by UPLC-MS/MS after oral administration of Uncaria rhynchophylla extract. Biomedical Chromatography, 28(3), 439-445. doi:10.1002/bmc.3052
9. Cheng, S., Lin, L.-C., Lin, C.-H., & Tsai, T.-H. (2013). Comment on pharmacokinetics and urine metabolite identification of dehydroevodiamine in the rat: From Boymia ruticarpa A. Juss. to Tetradium ruticarpum (A. Juss.) T.G. Hartley. Journal of Agricultural and Food Chemistry, 61(2), 472-472. doi:10.1021/jf304788k
10. Hsueh, T. Y., Wu, Y.-T., Lin, L.-C., Chiu, A. W., Lin, C.-H., & Tsai, T.-H. (2013). Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim extract on the pharmacokinetics of sildenafil in rats. Molecules, 18(6), 7323-7335. doi:10.3390/molecules18067323
11. Lin, L.-C., Tsai, T.-H., & Kuo, C.-L. (2013). Chemical constituents comparison of Codonopsis tangshen, Codonopsis pilosula var. modesta and Codonopsis pilosula. Natural Product Research, 27(19), 1812-1815. doi:10.1080/14786419.2013.778849
12. Lu, C.-M., Hou, M.-L., Lin, L.-C., & Tsai, T.-H. (2013). Chemical and physical methods to analyze a multicomponent traditional Chinese herbal prescription using LC-MS/MS, electron microscope, and congo red staining. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2013/952796
13. Wan-Ling, C.-L., Hou, M.-L., Chang, L.-W., Lee, C.-J., Tsai, Y.-M., Lin, L.-C., & Tsai, T.-H. (2013). Determination and pharmacokinetics of di-(2-ethylhexyl) phthalate in rats by ultra performance liquid chromatography with tandem mass spectrometry. Molecules, 18(9), 11452-11466. doi:10.3390/molecules180911452
14. Cheng, J.-J., Tsai, T.-H., & Lin, L.-C. (2012). New Alkaloids and Cytotoxic Principles from Sinomenium acutum. Planta Medica, 78(17), 1873-1877. doi:10.1055/s-0032-1327785
15. Don, M.-J., Lin, L.-C., & Chiou, W.-F. (2012). Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells. Phytomedicine, 19(6), 551-561. doi:10.1016/j.phymed.2012.01.006
16. Lin, C.-C., Yen, J.-C., Wu, Y.-T., Lin, L.-C., & Tsai, T.-H. (2012). Chemical analysis and transplacental transfer of oseltamivir and oseltamivir carboxylic Acid in pregnant rats. PLoS One, 7(10). doi:10.1371/journal.pone.0046062
17. Lin, L.-C., Li, S.-H., Wu, Y.-T., Kuo, K.-L., & Tsai, T.-H. (2012). Pharmacokinetics and urine metabolite identification of dehydroevodiamine in the rat. Journal of Agricultural and Food Chemistry, 60(7), 1595-1604. doi:10.1021/jf204365m
18. Shaw, L.-H., Lin, L.-C., & Tsai, T.-H. (2012). HPLC-MS/MS Analysis of a Traditional Chinese Medical Formulation of Bu-Yang-Huan-Wu-Tang and Its Pharmacokinetics after Oral Administration to Rats. PLoS One, 7(8). doi:10.1371/journal.pone.0043848
19. Tsai, Y.-M., Wan-Ling, C.-L., Chien, C.-F., Lin, L.-C., & Tsai, T.-H. (2012). Effects of polymer molecular weight on relative oral bioavailability of curcumin. International Journal of Nanomedicine, 7, 2957-2966. doi:10.2147/IJN.S32630
20. Wan-Ling, C.-L., Chien, C.-F., Lin, L.-C., & Tsai, T.-H. (2012). Isolation of gentiopicroside from Gentianae Radix and its pharmacokinetics on liver ischemia/reperfusion rats. Journal of Ethnopharmacology, 141(2), 668-673. doi:10.1016/j.jep.2011.08.001
21. Chiou, W.-F., Shen, C.-C., & Lin, L.-C. (2011). Anti-inflammatory principles from Balanophora laxiflora. Journal of Food and Drug Analysis, 19(4), 502-508.
22. Lin, L.-C., Chiou, C.-T., & Cheng, J.-J. (2011). 5-Deoxyflavones with cytotoxic activity from Mimosa diplotricha. Journal of Natural Products, 74(9), 2001-2004. doi:10.1021/np200307r
23. Lin, L.-C., Tsai, T.-H., & Su, S.-C. (2011). A novel 8.O.6′-neolignan from Taxillus theifer. Natural Product Research, 25(14), 1319-1323. doi:10.1080/14786419.2010.529443
24. Tsai, Y.-M., Chien, C.-F., Lin, L.-C., & Tsai, T.-H. (2011). Curcumin and its nano-formulation: The kinetics of tissue distribution and blood–brain barrier penetration. International Journal of Pharmaceutics, 416(1), 331-338. doi:10.1016/j.ijpharm.2011.06.030
25. Tsai, Y.-M., Jan, W.-C., Chien, C.-F., Lee, W.-C., Lin, L.-C., & Tsai, T.-H. (2011). Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats. Food Chemistry, 127(3), 918-925. doi:10.1016/j.foodchem.2011.01.059
26. Tsai, T.H., Liu, Y.C., Lin, L.C.* (2010) Flavonoids from Taxillus theifer. J. Food Drug Anal., 18:256–262.
27. Wu, Y.T., Lin, C.W., Lin, L.C., Chiu, A.W., Chen, K.K., Tsai, T.H. (2010) Analysis of biliary excretion of icariin in rats. J. Agric. Food Chem., 58:9905–9911.
28. Tsai,Y.J., Lin, L.C., Tsai, T.H. (2010) Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat. J. Agric. Food Chem.,58:4638–4643.
29. Wu, Y.T., Kao, Y.L., Lin, L.C., Tsai, T.H. (2010) Effects of a P-glycoprotein modulator on the pharmacokinetics and distribution of free levobupivacaine and bupivacaine in rats. Int. J. Pharm., 396:127–133.
30. Wang, G.J., Tsai, T.H., Chang, T.T., Chou, C.J., and Lin, L.C. (2009) "Lanostanes from Phellinus igniarius and their iNOS inhibitory activities." Planta Med., Vol.75, pp.1-6.
31. Liu, H.K., Tsai, T.H., Chang, T.T., Chou, C.J., and Lin, L.C.* (2009) "Lanostane-triterpenoids from fungus Phellinus gilvus." Phytochemistry, Vol.70, pp.558-563.
32. Lin, L.C., Chen, Y.F., Lee, W.C., Wu, Y.T., and Tsai, T.H. (2008) "Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS." J. Pharmaceut. Biomed. Anal., Vol.48, pp.909-917.
33. Tsai, T.H., and Lin, L.C.* (2008) "Phenolic glycosides and pyrrolidine alkaloids from Codonopsis tangshen." Chem. Pharm. Bull., Vol.56, pp.1546-1550.
34. Tsai, T.H., Wang, G.J., and Lin, L.C.* (2008) "Vasorelaxing alkaloids and flavonoids from Cassytha filiformis." J. Nat. Prod., Vol.71, pp.289-291.
35. Lin, L.C., Chen, Y.F., Tsai, T.R., and Tsai, T.H. (2007) "Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat." Anal. Chim. Acta, Vol.590, pp.173-179.
36. Wang, G.J., Tsai, T.H., and Lin, L.C.* (2007) "Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum." Phytochemistry, Vol.68, pp.2455-2464.
37. Lin, L.C., Wang, M.N., Tseng, T.Y., Sung, J.S., and Tsai, T.H. (2007) "Pharmacokinetics of (-)-epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distribution." J. Argic. Food Chem., Vol.55, pp.1517-1524.
38. Lin, L.C.*, Shen, C.C., Shen, Y.C., and Tsai, T.H. (2006) "Anti-inflammatory neolignans"  Piper kadsur. J. Nat. Prod., Vol.69, pp.842-844.
39. Shyr, M.H., Tsai, T.H., and Lin, L.C.* (2006) "Rossicasins A, B and rosicaside F, three new phenylpropanoid glycosides.” Boschniakia rossica. Chem. Pharm. Bull., Vol.54, pp.252-254.