2020 研究論文
Studies of coumarin derivatives for constitutive androstane receptor (CAR) activation
Juang SH, Hsieh MT, Hsu PL, Chen JL, Liu HK, Liang FP, Kuo SC, Chiu CY, Liu SH, Chou CH, Wu TS, Hung HY.
Molecules. 2020;26(1):164. doi: 10.3390/molecules26010164.
Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson’s disease
Lee IJ, Chao CY, Yang YC, Cheng JJ, Huang CL, Chiou CT, Huang HT, Kuo YHHuang NK.
Biomed Pharmacother. 2021;134:111170. doi: 10.1016/j.biopha.2020.111170. Epub 2020 Dec 28.
Structural sequencing and anti-inflammatory, anti-lung cancer activities of 1,4-α/β-sulfomalonoglucan in Antrodia cinnamomea
Lu MK, Chao CH, Hsu YC, Chang CC.
Int J Biol Macromol. 2021 Feb 15;170:307-316. doi: 10.1016/j.ijbiomac.2020.12.135. Epub 2020 Dec 29.
Synthesis of 2-(4-hydroxyphenyl)ethyl 3,4,5-trihydroxybenzoate and its inhibitory effect on sucrase and maltase
Li WT, Chuang YH, Liao JH, Hsieh JF.
Processes. 2020;8(12):1603. doi: 10.3390/pr8121603.
Helminthostachys zeylanica water extract ameliorates airway Hyperresponsiveness and Eosinophil infiltration by reducing oxidative stress and Th2 cytokine production in a mouse asthma model
Huang WC, Ting NC, Huang YL, Chen LC, Lin CF, Liou CJ.
Mediators Inflamm. 2020;2020: 1702935. doi: 10.1155/2020/1702935.
Disclosure of suboptimal health status through traditional Chinese medicine-based body constitution and pulse patterns
Kung YY, Kuo TBJ, Lai CT, Shen YCSu YC, Yang CCH.
Complement Ther Med. 2021;56:102607. doi: 10.1016/j.ctim.2020.102607. Epub 2020 Nov 19.
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study
Tsai KC, Huang YC, Liaw CC, Tsai CI, Chiou CT, Lin CJ, Wei WC, Lin SJ, Tseng YH, Yeh KM, Lin YL, Jan JT, Liang JJ, Liao CC, Chiou WF, Kuo YH, Lee SM, Lee MY, Su YC.
Biomed Pharmacother. 2021;133:111037. doi: 10.1016/j.biopha.2020.111037. Epub 2020 Nov 19.
Ugonin J improves metabolic disorder and ameliorates nonalcoholic fatty liver disease by regulating the AMPK/AKT signaling pathway
Chang TC, Chiou WC, Lai WH, Huang HC, Huang YLLiu HK, Liang YC, Huang C.
Pharmacol Res. 2021;163:105298. doi: 10.1016/j.phrs.2020.105298. Epub 2020 Nov 18.

Isolation of anti-VEGF monoclonal antibodies with neutralizing effects from an Astragalus-induced immune antibody library
Lee YC, Huang HT, Chang CD, Chen CT, Lin TY, Yang TW, Chang FL, Lu MK, Chiou CT, Chen WC, Pan SL, Tsai KC.

Int Immunopharmacol. 2020;88:107007. doi: 10.1016/j.intimp.2020.107007.

Metal‐free, DBU‐mediated, microwave‐assisted synthesis of Benzo[c]xanthones by tandem reactions of alkynyl‐1,3‐diketones

Liang YE, Barve BD, Kuo YH, Fang HW, Kuo TS, Li WT.

Adv. Synth. Catal. 2021;363(2):505-511. doi: 10.1002/adsc.202001169. Epub 2020 Nov 3.





Photosynthetic physiology of green and red Perilla frutescens varieties under drought conditions

Lin KH, Huang MY, Chen CC, Chang CC.

Indian J Hortic. 2020;77(3):469-477. doi: 10.5958/0974-0112.2020.00067.5.

Bioactive flavonoid glycosides and HPLC and UPLC quantification of commercial Astragali Complanati Semen

Kuo JC, Zhang LJ, Huang HT, Liaw CC, Lin ZH, Liu M, Kuo YH.

Molecules. 2020;25(20):4762. doi: 10.3390/molecules25204762.

The TCM treatment and drug development of COVID-19


月旦醫事法報告,48:7-162020doi: 10.3966/241553062020100048001.

Efficacy of cinnamon patch treatment for alleviating symptoms of overactive bladder: A double-blind, randomized, placebo-controlled trial

Chen LL, Shen YC, Ke CC, Imtiyaz Z, Chen HI, Chang CH, Lee MH.

Phytomedicine. 2021;80:153380. doi: 10.1016/j.phymed.2020.153380. Epub 2020 Oct 12.

Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer

Hsu WH, Qiu WL, Tsao SM, Tseng AJ, Lu MK, Hua WJ, Cheng HC, Hsu HY, Lin TY.

Int J Biol Macromol. 2020;165(Pt A):1604-1613. doi: 10.1016/j.ijbiomac.2020.09.227.




Anti-influenza virus activity and chemical components from the parasitic plant Cuscuta japonica Choisy on Dimocarpus longans Lour

Cheng JC, Liaw CC, Lin MK, Chen CJ, Chao CL, Chao CH, Kuo YH, Chiu YP, Peng YS, Huang HC.

Molecules. 2020;25(19):4427. doi: 10.3390/molecules25194427.

A new diterpene and anti-inflammatory sesquiterpene lactones from Sigesbeckia orientalis

Engels NS, Gierlikowska B, Waltenberger B, Chang FR, Kiss AK, Stuppner H.

Planta Med. 2020;86(15):1108-1117. doi: 10.1055/a-1232-6869.

In vitro and in vivo screening of wild bitter melon leaf for anti-inflammatory activity against Cutibacterium acnes

Chuang LT, Shih YH, Huang WC, Lin LC, Hsu C, Chyuan JH, Tsai TH, Tsai PJ.

Molecules. 2020;25(18):4277. doi: 10.3390/molecules25184277.

Household coverage, quality and costs of care provided by community health worker teams and the determining factors: findings from a mixed methods study in South Africa

Goudge J, de Kadt J, Babalola O, Muteba M, Tseng YH, Malatji H, Rwafa T, Nxumalo N, Levin J, Thorogood M, Daviaud E, Watkins J, Griffiths F.

BMJ Open. 2020;10(8):e035578. doi: 10.1136/bmjopen-2019-035578.

Response: Effect of tracheal intubation mode on cuff pressure during retractor splay and dysphonia recovery after anterior cervical spine surgery

Tan EC, Huang WC, Chu YC.

Spine (Phila Pa 1976). 2020;45(16):E1052-E1054. doi: 10.1097/BRS.0000000000003579.

In vivo and in vitro evaluation of the osteogenic potential of Davallia mariesii T. Moore ex Baker

Lin YT, Peng SW, Imtiyaz Z, Ho CW, Chiou WF, Lee MH.

J Ethnopharmacol. 2021;264:113126. doi: 10.1016/j.jep.2020.113126. Epub 2020 Aug 5.

Effects of sterol-type elicitors on biochemical characterization of polysaccharides from Antrodia cinnamomea

Lin TY, Lu MK, Tseng AJ, Chao CH.

Int J Biol Macromol. 2020;162:1476-1483. doi: 10.1016/j.ijbiomac.2020.07.201.

Healthy living practices in families and child health: 5-year follow-up of Taiwan Birth Cohort Study

Lin YC, Li YF, Chiang TL.

BMJ Open. 2020;10(7):e033613. doi: 10.1136/bmjopen-2019-033613.

Corrigendum to "cytotoxicity assessment of PM 2.5 collected from specific anthropogenic activities in Taiwan

Ngo TH, Tsai PC, Ueng YF, Chi KH.

Int J Environ Res Public Health. 2020;17(14):4932. doi: 10.3390/ijerph17144932.

Compounds isolated from Euonymus spraguei Hayata induce ossification through multiple pathways

Imtiyaz Z, Lin YT, Cheong UH, Jassey A, Liu HK, Lee MH.

Saudi J Biol Sci. 2020;27(9):2227-2237. doi: 10.1016/j.sjbs.2020.06.036.

Comprehensive LC-MS/MS-based phytochemical perspectives and osteogenic effects of Uraria crinita

Lin YT, Mao YW, Imtiyaz Z, Chiou WF, Lee MH.

Food Funct. 2020;11(6):5420-5431. doi: 10.1039/d0fo00782j.

Exploring the mechanism of flaccidoxide-13-acetate in suppressing cell metastasis of Hepatocellular carcinoma

Wu YJ, Wei WC, Dai GF, Su JH, Tseng YH, Tsai TC.

Mar Drugs. 2020;18(6):314. doi: 10.3390/md18060314.

1,2,3,4,6 penta-O-galloyl-β-D-glucose ameliorates high-fat diet-induced nonalcoholic fatty liver disease and maintains the expression of genes involved in lipid homeostasis in mice

Kant R, Lu CK, Nguyen HM, Hsiao HH, Chen CJ, Hsiao HP, Lin KJ, Fang CC, Yen CH.

Biomed Pharmacother. 2020;129:110348. doi: 10.1016/j.biopha.2020.110348.

Timing of rapid weight gain and its effect on subsequent overweight or obesity in childhood: findings from a longitudinal birth cohort study

Li YF, Lin SJ, Chiang TL.

BMC Pediatr. 2020;20(1):293. doi: 10.1186/s12887-020-02184-9.

T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice

Hsu WH, Shiao YJ, Chao YM, Huang YJ, Lin YL.

Aging (Albany NY). 2020;12(11):10556-10577. doi: 10.18632/aging.103279.

A high-sucrose diet aggravates Alzheimer's disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe/PS1dE9 mice

Yeh SH, Shie FS, Liu HK, Yao HH, Kao PC, Lee YH, Chen LM, Hsu SM, Chao LJ, Wu KW, Shiao YJ, Tsay HJ.

Neurobiol Aging. 2020;90:60-74. doi: 10.1016/j.neurobiolaging.2019.11.018. Epub 2019 Nov 27.

The mediating effect of dietary patterns on the association between mother's education level and the physical aggression of five-year-old children: a population-based cohort study

Wu WC, Lin CI, Li YF, Chang LY, Chiang TL.

BMC Pediatr. 2020;20(1):221. doi: 10.1186/s12887-020-02126-5.

Production, characterization, and functions of sulfated polysaccharides from zinc sulfate enriched cultivation of Antrodia cinnamomea

Lee MH, Chao CH, Hsu YC, Lu MK.

Int J Biol Macromol. 2020;159:1013-1021. doi: 10.1016/j.ijbiomac.2020.05.068.

Cucurbitane-type triterpenoids from the vines of Momordica charantia and their anti-inflammatory activities

Huang HT, Zhang LJ, Huang HC, Hwang SY, Wu CL, Lin YC, Liaw CC, Cheng YY, Morris-Natschke SL, Huang CY, Lee KH, Kuo YH.

J Nat Prod. 2020;83(5):1400-1408. doi: 10.1021/acs.jnatprod.9b00592.

Structural identification of a fucose-containing 1,3-β-mannoglucan from Poria cocos and its anti-lung cancer CL1-5 cells migration via inhibition of TGFβR-mediated signaling

Lin TY, Lu MK, Chang CC.

Int J Biol Macromol. 2020;157:311-318. doi: 10.1016/j.ijbiomac.2020.04.014.

Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression

Huang TT, Tseng LM, Chen JL, Chu PY, Lee CH, Huang CT, Wang WL, Lau KY, Tseng MF, Chang YY, Chiang TY, Ueng YF, Lee HC, Dai MS, Liu CY.

EBioMedicine. 2020;54:102717. doi: 10.1016/j.ebiom.2020.102717.

Taipei consensus on integrative traditional Chinese and Western Medicine

Lue HC, Su YC, Lin SJ, Huang YC, Chang YH, Lin IH, Yang SP.

J Formos Med Assoc. 2021;120(1 Pt 1):34-47. doi: 10.1016/j.jfma.2020.02.005. Epub 2020 Mar 6.

Astragalus membranaceus–derived anti-programmed death-1 monoclonal antibodies with immunomodulatory therapeutic effects against tumors

Chang FL, Tsai KC, Lin TY, Yang TW, Lo YN, Chen WC, Chang JH, Lu MK, Chiou CT, Chen PH, Yen Y, Pan SL, Lee YC.

Biomed Res Int. 2020;2020:3415471. doi: 10.1155/2020/3415471. eCollection 2020.

Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data

Kloudova-Spalenkova A, Ueng YF, Wei S, Kopeckova K, Peter Guengerich F, Soucek P.

J Steroid Biochem Mol Biol. 2020;197:105566. doi: 10.1016/j.jsbmb.2019.105566. Epub 2019 Dec 23.

Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer’s disease

Tseng HJ, Lin MH, Shiao YJ, Yang YC, Chu JC, Chen CY, Chen YY, Lin TE, Su CJ, Pan SL, Chen LC, Wang CY, Hsu KC, Huang WJ.

Eur J Med Chem. 2020;192:112193. doi: 10.1016/j.ejmech.2020.112193.

Comparisons of chlorophyll fluorescence and physiological characteristics of wheat seedlings influenced by iso-osmotic stresses from polyethylene glycol and sodium chloride

Lan CY, Lin KH, Chen CL, Huang WD, Chen CC.

Agronomy (Basel). 2020;10(3):325. doi: 10.3390/agronomy10030325.

Bioassay-guided isolation and HPLC quantification of antiproliferative metabolites from Stahlianthus thorelii

Nguyen NL, Vo TH, Lin YC, Liaw CC, Lin ZH, Chen MC, Kuo YH.

Molecules. 2020;25(3):551. doi: 10.3390/molecules25030551.

Design and synthesis of 3-benzylaminocoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors

Hng Y, Lin MH, Lin TS, Liu IC, Lin IC, Lu YL, Chang CN, Chiu PF, Tsai KC, Chen MJ, Liang PH.

Bioorg Chem. 2020;96:103618. doi: 10.1016/j.bioorg.2020.103618.

A (1→6)-branched (1→4)-β-D-glucan from Grifola frondosa inhibits lipopolysaccharide-induced cytokine production in RAW264.7 macrophages by binding to TLR2 rather than Dectin-1 or CR3 receptors

Su CH, Lu MK, Lu TJ, Lai MN, Ng LT.

J Nat Prod. 2020;83(2):231-242. doi: 10.1021/acs.jnatprod.9b00584. 

Physiochemical changes and mechanisms of anti-inflammation effect of sulfated polysaccharides from ammonium sulfate feeding of Antrodia cinnamomea

Lu MK, Lee MH, Chao CH, Hsu YC.

Int J Biol Macromol. 2020;148:715-721. doi: 10.1016/j.ijbiomac.2020.01.110.