2021 研究論文
Bacillus subtilis natto derivatives inhibit enterococcal biofilm formation via restructuring of the cell envelope
Liaw CC, Huang HT, Liu HK, Lin YC, Zhang LJ, Wei WC, Shen CC, Wu CL, Huang CY, Kuo YH.
Phytochemistry. 2021;195:113026. doi: 10.1016/j.phytochem.2021.113026. Online ahead of print.
Cucurbitane-type triterpenoids from the vines of Momordica charantia and their anti-inflammatory, cytotoxic, and antidiabetic activity
Liaw CC, Huang HT, Liu HK, Lin YC, Zhang LJ, Wei WC, Shen CC, Wu CL, Huang CY, Kuo YH.
Phytochemistry. 2021;195:113026. doi: 10.1016/j.phytochem.2021.113026. Online ahead of print.
Aspirin and Sulindac act via different mechanisms to inhibit store-operated calcium channel: Implications for colorectal cancer metastasis
Wang YS, Huang NK, Lin YC, Chang WC, Huang WC.
Biomed Pharmacother. 2022;145:112476. doi: 10.1016/j.biopha.2021.112476. Epub 2021 Dec 1.
Graptopetalum paraguayense extract ameliorates proteotoxicity in aging and age-related diseases in model systems
Chen YX, Le PTN, Tzeng TT, Tran TH, Nguyen AT, Cheng IH, Huang CF, Shiao YJ, Ching TT.
Nutrients. 2021;13(12):4317. doi: 10.3390/nu13124317.
A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor
Chen M, Sheu MT, Cheng TL, Roffler SR, Lin SY, Chen YJ, Cheng YA, Cheng JJ, Chang HY, Wu TY, Kao AP, Ho YS, Chuang KH.
Biomater Sci. 2021;10(1):202-215. doi: 10.1039/d1bm01218e.
Healthcare resource utilization in patients treated with empagliflozin in East Asia
Sheu WH, Seino Y, Tan EC, Yabe D, Ha KH, Nangaku M, Chung WJ, Node K, Yasui A, Lei WY, Lee S,
J Diabetes Investig. 2021. doi: 10.1111/jdi.13728. Online ahead of print.
Pd-Catalyzed and ligand-enabled alkene difunctionalization via unactivated C-H bond functionalization
Barve BD, Kuo YH, Li WT.
Chem Commun (Camb). 2021;57(91):12045-12057. doi: 10.1039/d1cc04397h.
Diterpenoid compounds isolated from Chloranthus oldhamii Solms exert anti-inflammatory effects by inhibiting the IKK/NF-κB pathway
Chiu LC, Wang JY, Lin CH, Hsu CH, Lin LC, Fu SL.
Molecules. 2021;26(21):6540. doi: 10.3390/molecules26216540.
Efficacy and safety of Duhuo Jisheng Decoction add-on bisphosphonate medications in patients with osteoporosis: A meta-analysis of randomized controlled trials
Huang CY, Cheng CJ, Chiou WF, Chang WC, Kang YN, Lee MH.
J Ethnopharmacol. 2022;283:114732. doi: 10.1016/j.jep.2021.114732. Epub 2021 Oct 9.
Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCP
Huang H, Huang HC, Chiou WC, Lin LC, Chen JC, Liu HK, Lai YH, Huang C.
Antiviral Res. 2021;195:105184. doi: 10.1016/j.antiviral.2021.105184.
Antioxidant properties of red raspberry extract alleviate hepatic fibrosis via inducing apoptosis and transdifferentiation of activated hepatic stellate cells
Wu TH, Wang PW, Lin TY, Yang PM, Li WT, Yeh CT, Pan TL.
Biomed Pharmacother. 2021;144:112284. doi: 10.1016/j.biopha.2021.112284.
Effect of carbohydrate-feeding strategy on the production, physiochemical changes, anti-inflammation activities of polysaccharides of Poria cocos
Lu MK, Chao CH , Hsu YC.
Int J Biol Macromol. 2021;192:435-443. doi: 10.1016/j.ijbiomac.2021.10.017.
EK100 and antrodin C improve brain amyloid pathology in APP/PS1 transgenic mice by promoting microglial and perivascular clearance pathways
Tsay HJ, Liu HK, Kuo YH, Chiu CS, Liang CC, Chung CW, Chen CC, Chen YP, Shiao YJ.
Int J Mol Sci. 2021;22(19):10413. doi: 10.3390/ijms221910413.
Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy
Kuo TF, Hsu SW, Huang SH, Chang CL, Feng CS, Huang MG, Chen TY, Yang MT, Jiang ST, Wen TN, Yang CY, Huang CY, Kao SH, Tsai KC, Yang G, Yang WC.
EMBO Mol Med. 2021:e11668. doi: 10.15252/emmm.201911668.
Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulating JAK2/STAT3-mediated iNOS expression
Lin ZH, Hu J, Shi H, Liaw CC, Qiu WL, Hsu WH, Lin TY.
J Ethnopharmacol. 2021;282:114636. doi: 10.1016/j.jep.2021.114636.
Factors influencing the use of health information exchange by physicians-using the National Health Insurance PharmaCloud system in Taiwan
Chuang CH, Li YF, Kuo LC, Yang MC, Kao LT.
Int J Environ Res Public Health. 2021;18(16):8415. doi: 10.3390/ijerph18168415.
Comprehensive deep mutational scanning reveals the immune-escaping hotspots of SARS-CoV-2 receptor-binding domain targeting neutralizing antibodies
Tsai KC, Lee YC and Tseng TS.
Front Microbiol. 2021;12:1812. doi: 10.3389/fmicb.2021.698365.
Compounds isolated from Wikstroemia taiwanensis regulate none remodeling by modulating osteoblast and osteoclast activities
Imtiyaz Z, Lin YT, Liang FY, Chiou WF, Lee MH.
Front Pharmacol. 2021;12:670254. doi: 10.3389/fphar.2021.670254. eCollection 2021.
Real-world cost-effectiveness analysis of the fracture liaison services model of care for hip fracture in Taiwan
Chien LN, Li YF, Yang RS, Yang TH, Chen YH, Huang WJ, Tsai HY, Li CY, Chan DC.
J Formos Med Assoc. 2021:S0929-6646(21)00243-6. doi: 10.1016/j.jfma.2021.05.028. Online ahead of print.
Quantification and optimization of ethanolic extract containing the bioactive flavonoids from Millettia pulchra radix
Vo TH, Liaw CC, Lin YC, Nguyen DH, Nguyen TTN, Lee CK, Kuo YH.
Molecules. 2021;26(12):3641. doi: 10.3390/molecules26123641.
Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
Huang HJ, Wang HT, Yeh TY, Lin BW, Shiao YJ, Lo YL, Lin AM.
Sci Rep. 2021;11(1):12497. doi: 10.1038/s41598-021-91507-6.
Effect of You-Gui-Wan on house dust mite-induced mouse allergic asthma via regulating amino acid metabolic disorder and gut dysbiosis
Hsu WH, Lin LJ, Lu CK, Kao ST, Lin YL.
Biomolecules. 2021;11(6):812. doi: 10.3390/biom11060812.
Triterpene acids from Mesona procumbens exert anti-inflammatory effects on LPS-stimulated murine macrophages by regulating the MAPK signaling pathway
Huang HT, Liaw CC, Chiou CTKuo YH, Lee KT.
J Agric Food Chem. 2021;69(22):6271-6280. doi: 10.1021/acs.jafc.1c01810.
Bioprocessing of marine chitinous wastes for the production of bioactive prodigiosin
Nguyen TH, Wang SL, Nguyen DN, Nguyen AD, Nguyen TH, Doan MD, Ngo VA, Doan CT, Kuo YH, Nguyen VB.
Molecules. 2021;26(11):3138. doi: 10.3390/molecules26113138.
Quorum quenching activity of Andrographis paniculata (Burm f.) Nees andrographolide compounds on metallo-β-lactamase-producing clinical isolates of Pseudomonas aeruginosa PA22 and PA247 and their effect on lasR gene expression
Tan Lim AM, Oyong GG, Tan MCS, Shen CC, Ragasa CY, Cabrera EC.
Heliyon. 2021;7(5):e07002. doi: 10.1016/j.heliyon.2021.e07002. eCollection 2021 May.



Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation
Hsu WH, Huang NK, Shiao YJ, Lu CK, Chao YM, Huang YJ, Yeh CH, Lin YL.
Phytomedicine. 2021;87:153576. doi: 10.1016/j.phymed.2021.153576. 

Isomalabaricane triterpenes from the marine sponge Rhabdastrella sp.
Lai KH, Huang ZH, El-Shazly M, Peng BR, Wei WC, Su JH.
Mar Drugs. 2021;19(4):206. doi: 10.3390/md19040206.

Protein unbound pharmacokinetics of ambroxol in the blood and brains of rats and the interaction of ambroxol with Polygala tenuifolia by multiple microdialysis
Yang CN, Peng WY, Lin LC, Tsai TH.
J Ethnopharmacol. 2021;269:113764. doi: 10.1016/j.jep.2020.113764. Epub 2020 Dec 28.
Bioactive compounds, antioxidants, and health benefits of sweet potato leaves
Nguyen HC, Chen CC, Lin KH, Chao PY, Lin HH, Huang MY.
Molecules. 2021;26(7):1820. doi: 10.3390/molecules26071820.
Synthesis, biological evaluation, and correlation of cytotoxicity versus redox potential of 1,4-naphthoquinone derivatives
Shen CC, Afraj SN, Hung CC, Barve BD, Kuo LY, Lin ZH, Ho HO, Kuo YH.
Bioorg Med Chem Lett. 2021;41:127976. doi: 10.1016/j.bmcl.2021.127976.
Generation of avian-derived anti-B7-H4 antibodies exerts a blockade effect on the immunosuppressive response
Lin TY, Tsai TH, Chen CT, Yang TW, Chang FL, Lo YN, Chung TS, Cheng MH, Chen WC, Tsai KC, Lee YC.
Exp Anim. 2021. doi: 10.1538/expanim.20-0178. Online ahead of print.
A leaf disc assay for evaluating the response of tea (Camellia sinensis) to PEG-Induced osmotic stress and protective effects of azoxystrobin against drought
Chiu YC, Chen BJ, Su YS, Huang WD, Chen CC.
Plants (Basel). 2021;10(3):546. doi: 10.3390/plants10030546.
Synergistic anti-inflammatory effects of different polysaccharide components from Xylaria nigripes
Jen CI, Su CH, Lu MK, Lai MN, Ng LT.
J Food Biochem. 2021;45(4):e13694. doi: 10.1111/jfbc.13694.
Practice and outcomes of airway management in patients with cervical orthoses
Liu YC, Huang WC, Tan EC, Huang SS, Wang YK, Chu YC.
J Formos Med Assoc. 2021:S0929-6646(21)00059-0. doi: 10.1016/j.jfma.2021.02.002. Online ahead of print.
Targeted isolation of xenicane diterpenoids from Taiwanese soft coral Asterospicularia laurae
Lin YC, Chen YJ, Chen SR, Lien WJ, Chang HW, Yang YL, Liaw CC, Su JH, Chen CY, Cheng YB.
Mar Drugs. 2021;19(3):123. doi: 10.3390/md19030123.
Postoperative sore throat helps predict swallowing disturbance on postoperative day 30 of anterior cervical spine surgery: A secondary exploratory analysis of a randomized clinical trial of tracheal intubation modes
Huang WC, Tan EC, Huang SS, Chou CJ, Chang WK, Chu YC.
Dysphagia. 2021. doi: 10.1007/s00455-021-10247-x. Online ahead of print.
Synthesis of yakuchinone B-inspired inhibitors against islet amyloid polypeptide aggregation
Hsu JY, Rao Sathyan A, Hsu KC, Chen LC, Yen CC, Tseng HJ, Wu KC, Liu HK, Huang WJ.
J Nat Prod. 2021;84(4):1096-1103. doi: 10.1021/acs.jnatprod.0c01162. 
Anti-inflammatory constituents from Phyllostachys makinoi Hayata
Liaw CC, Lin YC, Wu SY, Kuo JC, Lin ZH, Lin KW, Hui-Chi H, Yang Kuo LM, Kuo YH.
Nat Prod Res. 2021:1-8. doi: 10.1080/14786419.2021.1885406. Online ahead of print.
Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats
Chiang TY, Wang HJ, Wang YC, Chia-Hui Tan E, Lee IJ, Yun CH, Ueng YF.
J Ethnopharmacol. 2021;271:113914. doi: 10.1016/j.jep.2021.113914. 
Comparative biotransformation of luteolin and apigenin from the flower extract and the stem-and-leaf extract of Dendranthema morifolium Ramat. Tzvel. in rats
Chiang YH, Wu YT, Lin LC, Tsai TH.
J Sci Food Agric. 2021. doi: 10.1002/jsfa.11137. Online ahead of print.
Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity
Vo TH, Lin YC, Liaw CC, Pan WP, Cheng JJ, Lee CK, Kuo YH.
Phytochemistry. 2021;184:112666. doi: 10.1016/j.phytochem.2021.112666.
Water-use efficiency and nitrogen uptake in rice seedlings grown under different light quality
Chen CC, Huang WD, Yang ZW, Yang CM, Rogers K.
Not Bot Horti Agrobo. 2021;49(1):12127. doi: 10.1016/j.phytochem.2021.112666.
Author Correction: Anti-inflammatory effect of afatinib (an EGFR-TKI) on OGD-induced neuroinflammation
Chen YJ, Hsu CC, Shiao YJ, Wang HT, Lo YL, Lin AMY.
Sci Rep. 2021;11(1):2693. doi: 10.1038/s41598-020-80901-1.
Cardiovascular and renal effectiveness of empagliflozin in routine care in East Asia: Results from the EMPRISE East Asia study
Seino Y, Kim DJ, Yabe D, Tan EC, Chung WJ, Ha KH, Nangaku M, Node K, Klement R, Yasui A, Lei WY, Lee S, Kyaw MH, Deruaz-Luyet A, Brodovicz KG, H-H Sheu W; EMPRISE East Asia study group.
Endocrinol Diabetes Metab. 2020;4(1):e00183. doi: 10.1002/edm2.183. eCollection 2021 Jan.
Arenarosides A–G, Polyhydroxylated Oleanane-Type Saponins from Polycarpaea arenaria and their Cytotoxic and Antiangiogenic Activities
Nguyen NL, Vo TH, Lin YC, Liaw CC, Lu MK, Cheng JJ, Chen MC, Kuo YH.
J Nat Prod. 2021;84(2):259-267. doi: 10.1021/acs.jnatprod.0c00919.
Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase
Tung MC, Tsai KC (co-first), Fung KM, Don MJ, Tseng TS.
RSC Adv. 2021;11:2453-2461. doi: 10.1039/D0RA08769F.