黃宏澤（Huang, Hung-Tse）

黃宏澤 大頭照

姓名：黃宏澤（Huang, Hung-Tse）
職稱：助理研究員
電話： 02-28201999轉8571
E-mail : hthuang@nricm.edu.tw

學歷：
國立臺灣大學 生化科技學系 博士

主要經歷：
衛生福利部國家中醫藥研究所 博士後研究員 (110.08-114.06)

專長：
中草藥活性成分、多醣體化學分析與鑑定

研究簡介：
本研究室專注於中草藥水萃物與醇萃物之活性成分分離純化與鑑定，並針對具有活性的多醣體進行分離純化與鑑定。

期刊論文(Publications)：限所內研究人員(用Email)點選編輯點此編輯

       NCBI PubMed:  Hung-Tse Huang (Please click!!)

  1. Wu CY, Huang HT, Chiang YT, Lee KT. Surfactin inhibits enterococcal biofilm formation via interference with pilus and exopolysaccharide biosynthesis. BMC Microbiol. 2025;25(1):85.
  2. Lin SY, Chang CL, Liou KT, Kao YK, Wang YH, Chang CC, Kuo TBJ, Huang HT, Yang CCH, Liaw CC, Shen YC. The protective role of Achyranthes aspera extract against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and PANoptosis. J Ethnopharmacol. 2024:117097.
  3. Huang HT, Lo IW, Lin YC, Liao GY, Lin YS, Zhang LJ, Lee KT, Liaw CC, Kuo YH. Kaguacidine A: a novel spirohydantoin-containing cucurbitane glycoside from vines of Momordica charantia L. Nat Prod Res. 2024:2179-2186. 
  4. Loo YC, Tsai YH, Chen H, Hsieh HP, Chen YC, Chen HE, Lin ZH, Huang HT, Liu IM, Liaw CC, Chang FR.  Quality and production enhancement of fish mint, Houttuynia cordata Thunb., cultivated in a hydroponic planting system with designed plant growth-promoting additives. Heliyon. 2024;10(7):e28755.
  5. Liu SH, Huang HT, Lo IW, Lin YC, Liao GY, Chao CH, Huang HC, Chang FR, Li TL, Shen YC, Liaw CC. Potential natural product 3,4-seco-schitriterpenoids from Kadsura japonica L. as anti-neuroinflammatory agents. Bioorg Chem. 2023;141:106843.
  6. Lin SY, Chang CL, Liou KT, Kao YK, Wang YH, Chang CC, Kuo TBJ, Huang HT, Yang CCH, Liaw CC, Shen YC. The protective role of Achyranthes aspera extract against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and PANoptosis. J Ethnopharmacol. 2023:117097.
  7. Chang SS, Huang HT, Wei WC, Lo IW, Lin YC, Chao CH, Liao GY, Shen YC, Chen JJ, Li TL, Lin LT, Tai CJ, Kuo YH, Liaw CC. Anti-inflammatory effect of euphane- and triucallane-type triterpenes isolated from the traditional herb Euphorbia neriifolia L.  Front Chem. 2023;11:1223335.
  8. Nguyen VB, Wang SL, Phan TQ, Thoa Pham TH, Huang HT, Liaw CC, Nguyen AD. Screening and elucidation of chemical structures of novel mammalian α-glucosidase inhibitors targeting anti-diabetes drug from herbals used by E De Ethnic Tribe in Vietnam. Pharmaceuticals (Basel). 2023;16(5):756.
  9. Huang HT, Lo IW, Lin YC, Liao GY, Lin YS, Zhang LJ, Lee KT, Liaw CC, Kuo YH. Kaguacidine A: a novel spirohydantoin-containing cucurbitane glycoside from vines of Momordica charantia L. Nat Prod Res. 2023:1-8. 
  10. Huang HT, Lo IW, Liao GY, Lin YC, Shen YC, Huang HC, Li TL, Lee KT, Kuo YH, Liaw CC. Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley. Front Chem. 2022;10:1003356.
  11. Chang SS, Huang HT, Lin YC, Chao CH, Liao GY, Lin ZH, Huang HC, Kuo J CL, Liaw CC, Tai CJ, Kuo YH. Neritriterpenols A-G, euphane and tirucallane triterpenes from Euphorbia neriifolia L. and their bioactivity. Phytochemistry. 2022;199:113199.
  12. Liaw CC, Lo IW, Lin YC, Huang HT, Zhang LJ, Hsiao PC, Li TL, Kuo YH. Four cucurbitane glycosides taimordisins A-D with novel furopyranone skeletons isolated from the fruits of Momordica charantia. Food Chem X. 2022;14:100286.
  13. Liaw CC, Huang HT, Liu HK, Lin YC, Zhang LJ, Wei WC, Shen CC, Wu CL, Huang CY, Kuo YH. Cucurbitane-type triterpenoids from the vines of Momordica charantia and their anti-inflammatory, cytotoxic, and antidiabetic activity. Phytochemistry. 2022;195:113026.
  14. Lin YC, Wu CY, Huang HT, Lu MK, Hu WS, Lee KT. Bacillus subtilis natto Derivatives Inhibit Enterococcal Biofilm Formation via Restructuring of the Cell Envelope. Front Microbiol. 2021;12:785351. 
  15. Shih MK, Tain YL, Cheng CM, Hsu CN, Chen YW, Huang HT, Chang CI, Hou CY. Separation and Identification of Resveratrol Butyrate Ester Complexes and Their Bioactivity in HepG2 Cell Models. Int J Mol Sci. 2021;22(24):13539.
  16. Huang HT, Liaw CC, Lin YC, Liao GY, Chao CH, Chiou CT, Kuo YH, Lee KT. New Diterpenoids from Mesona procumbens with Antiproliferative Activities Modulate Cell Cycle Arrest and Apoptosis in Human Leukemia Cancer Cells. Pharmaceuticals (Basel). 2021;14(11):1108.
  17. Huang HT, Liaw CC, Chiou CT, Lee KT, Kuo YH. Mesonosides A-H, primeverose derivatives from Mesona procumbens suppress adipogenesis by downregulating PPARγ and C/EBPa in 3T3-L1 cells. J Food Drug Anal. 2021;29(3):448-467.
  18. Huang HT, Lin YC, Zhang LJ, Liaw CC, Chen HY, Hsueh MT, Kuo YH. Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis. Nat Prod Res. 2021;35(16):2707-2714.
  19. Huang HT, Liaw CC, Chiou CT, Kuo YH, Lee KT. Triterpene Acids from Mesona procumbens Exert Anti-inflammatory Effects on LPS-Stimulated Murine Macrophages by Regulating the MAPK Signaling Pathway. J Agric Food Chem. 2021;69(22):6271-6280.
  20. Tain YL, Chang SKC, Liao JX, Chen YW, Huang HT, Li YL, Hou CY. Synthesis of Short-Chain-Fatty-Acid Resveratrol Esters and Their Antioxidant Properties. Antioxidants (Basel). 2021;10(3):420.
  21. Lee IJ, Chao CY, Yang YC, Cheng JJ, Huang CL, Chiou CT, Huang HT, Kuo YH, Huang NK. Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson's disease. Biomed Pharmacother. 2021;134:111170.
  22. Kuo JCL, Zhang LJ, Huang HT, Liaw CC, Lin ZH, Liu M, Kuo YH.Bioactive Flavonoid Glycosides and HPLC and UPLC Quantification of Commercial Astragali Complanati Semen. Molecules. 2020;25(20):4762. 
  23. Huang HT, Zhang LJ, Huang HC, Hwang SY, Wu CL, Lin YC, Liaw CC, Cheng YY, Morris-Natschke SL, Huang CY, Lee KH, Kuo YH. Cucurbitane-Type Triterpenoids from the Vines of Momordica charantia and Their Anti-inflammatory Activities. J Nat Prod. 2020;83(5):1400-1408.
  24. Huang NK, Lin CC, Lin YL, Huang CL, Chiou CT, Lee YC, Lee SY, Huang HT, Yang YC. Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations. Phytomedicine. 2019;59:152756.
  25. Yang JM, Huang HM, Cheng JJ, Huang CL, Lee YC, Chiou CT, Huang HT, Huang NK, Yang YC. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway. Toxicology. 2018;410:65-72.
  26. Nguyen VB, Wang SL, Nguyen AD, Lin ZH, Doan CT, Tran TN, Huang HT, Kuo YH. Bioactivity-Guided Purification of Novel Herbal Antioxidant and Anti-NO Compounds from Euonymus laxiflorus Champ. Molecules. 2018;24(1):120.
  27. Huang HT, Wang SL, Nguyen VB, Kuo YH. Isolation and Identification of Potent Antidiabetic Compounds from Antrodia cinnamomea-An Edible Taiwanese Mushroom. Molecules. 2018;23(11):2864.
  28. Zhang LJ, Huang HT, Huang SY, Lin ZH, Shen CC, Tsai WJ, Kuo YH. Antioxidant and Anti-Inflammatory Phenolic Glycosides from Clematis tashiroi. J Nat Prod. 2015;78(7):1586-92.
  29. Yang Kuo LM, Zhang LJ, Huang HT, Lin ZH, Liaw CC, Cheng HL, Lee KH, Morris-Natschke SL, Kuo YH, Ho HO. Antioxidant lignans and chromone glycosides from Eurya japonica. J Nat Prod. 2013;76(4):580-7.
  30. Zhang LJ, Cheng JJ, Liao CC, Cheng HL, Huang HT, Kuo LM, Kuo YH. Triterpene acids from Euscaphis japonica and assessment of their cytotoxic and anti-NO activities. Planta Med. 2012;78(14):1584-90.
  31. Shen CC, Hong KY, Chen J, Zhang LJ, Lin ZH, Huang HT, Cheng HL, Kuo YH. Antioxidant and anti-nitric oxide components from Quercus glauca. Chem Pharm Bull (Tokyo). 2012;60(7):924-9.