藍耀東（Lang, Yaw-Dong）

藍耀東（Lang, Yaw-Dong）Image

Current position: Assistant Research Fellow
Education: Ph.D., Graduate Institute of Medical Sciences, Taipei Medical University
Telephone: +886-2-2820-1999 ext. 7531 (Office)
E-mail: ydlang@nricm.edu.tw


Professional Experiences:
Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica
Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica
Project Research Scientist, Institute of Biomedical Sciences, Academia Sinica
Postdoctoral Fellow, College of Medicine, National Yang Ming Chiao Tung University
Assistant Research Fellow, Center of Excellence for Cancer Research, National Yang Ming Chiao Tung University
Medical Researcher, Department of Medical Research, Taipei Medical University Hospital
Adjunct Assistant Professor, Graduate Institute of Clinical Medicine, Taipei Medical University

 

Academic Honorary Achievement:
Excellent Poster Award, Taiwan International Innovative Biomedical Summit (TIIBS)
Excellent Poster Award, The 27th Symposium on Recent Advances in Cellular and Molecular Biology
Excellent Paper Award, Liver Disease Prevention and Treatment Research Foundation
2019 Postdoctoral Research Academic Award, Ministry of Science and Technology (MOST)


Specialty:

  1. Multiomics research platform for herbal medicine as an adjuvant in cancer drug resistance
  2. Research platform for herbal medicine in experimental cancer animal models
  3. Study on the correlation between tumor microenvironment and herbal medicine application in tumor organoid models
  4. Precision medicine using liquid biopsy in patients treated with herbal medicine


Research Description:

This laboratory focuses on three major challenges: cancer drug resistance, immune escape, and treatment response monitoring. Through the integration of multiomics, animal models, and liquid biopsy technologies, we explore mechanisms and develop clinical translational applications.

  1. Mechanisms of herbal medicine in cancer drug resistance and metastasis: Combining multiomics analysis and cancer animal platforms to investigate the role of herbal medicines or natural products in tumor drug resistance and metastasis, clarifying the key roles of exosomes and tumor microenvironment remodeling.
  2. Impact on immunotherapy for non-small cell lung cancer (NSCLC): Investigating the regulatory mechanisms of Scutellaria baicalensis (Huang Qin), oxidative proteins, and signaling on PD-L1 expression, evaluating their role in modulating sensitivity to immune checkpoint inhibitors, and developing potential molecular biomarkers.
  3. Liquid biopsy application in Yttrium-90 (Y-90) radioembolization: Establishing a detection platform for exosomes and circulating cell-free DNA (cfDNA) to monitor recurrence risk in patients with hepatobiliary malignancies undergoing Y-90 radioembolization. We aim to develop early prognostic and treatment decision indicators, integrating this experience into the application of precision Traditional Chinese Medicine (TCM).

Published Papers:
      NCBI PubMed :  Yaw-dong Lang (Please click!!)
  1. Yeh HW, Lang YD (co-first), Lee HY, Jou YS. PSPC1 bridges cancer stemness and malignancy in acute yeloid leukemia. Cell Stem Cell. 2025 Mar 6;32(3):335-337. doi:10.1016/j.stem.2025.02.006. PMID: 40054451.
  2. Lin TY, Gu SY, Lin YH, Shih JH, Lin JH, Chou TY, Lee YC, Chang SF, Lang YD*. Paclitaxel-resistance facilitates glycolytic metabolism via Hexokinase-2-regulated ABC and SLC transporter genes in ovarian clear cell carcinoma. Biomed Pharmacother. 2024 Nov;180:117452. doi: 10.1016/j.biopha.2024.117452. Epub 2024 Sep 28. PMID: 39341074.
  3. Chen KJ, Huang JH, Shih JH, Gu DL, Lee SS, Shen R, Hsu YH, Kung YC, Wu CY, Ho CM, Jen HW, Lee HY, Lang YD, Hsiao CH, Jou YS. Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinoma. Mol Carcinog. 2023 Mar;62(3):348-359. doi: 10.1002/mc.23490. Epub 2022 Dec 1. PMID: 36453714; PMCID: PMC10107479.
  4. Chen HY, Chan SJ, Liu X, Wei AC, Jian RI, Huang KW, Lang YD, Shih JH, Liao CC, Luan CL, Kao YT, Chiang SY, Hsiao PW, Jou YS, Chen Y, Chen RH. Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression. J Hematol Oncol. 2022 Jul 6;15(1):85. doi: 10.1186/s13045-022-01306-3. PMID: 35794621; PMCID: PMC9258208.
  5. Lang YD, Jou YS. PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression. J Biomed Sci. 2021 Aug 2;28(1):57. doi: 10.1186/s12929-021-00753-3. PMID: 34340703; PMCID: PMC8327449.
  6. Jen HW, Gu DL, Lang YD, Jou YS. PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility. Cells. 2020 Jun 18;9(6):1490. doi:10.3390/cells9061490. PMID: 32570949; PMCID: PMC7349238.
  7. Shih JH, Chen HY, Lin SC, Yeh YC, Shen R, Lang YD, Wu DC, Chen CY, Chen RH, Chou TY, Jou YS. Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma. Nucleic Acids Res. 2020 Feb 20;48(3):1175-1191. doi:10.1093/nar/gkz1149. PMID: 31853539; PMCID: PMC7026595.
  8. Lang YD, Jou YS. PSPC1: a contextual determinant of tumor progression. Mol Cell Oncol. 2020 Feb 3;7(2):1721253. doi: 10.1080/23723556.2020.1721253. PMID: 32158931; PMCID: PMC7051164.
  9. Lang YD, Chen HY, Ho CM, Shih JH, Hsu EC, Shen R, Lee YC, Chen JW, Wu CY, Yeh HW, Chen RH, Jou YS. PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression. Nat Commun. 2019 Dec 16;10(1):5716. doi: 10.1038/s41467-019-13665-6. PMID: 31844057;PMCID: PMC6914800.
  10. Yeh HW, Lee SS, Chang CY, Lang YD, Jou YS. A New Switch for TGFβ in Cancer. Cancer Res. 2019 Aug 1;79(15):3797-3805. doi: 10.1158/0008-5472.CAN-18-2019. Epub 2019 Jul 12. PMID: 31300476.
  11. Chen HY, Lang YD, Lin HN, Liu YR, Liao CC, Nana AW, Yen Y, Chen RH. miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2. Sci Rep. 2019 Jul 4;9(1):9687. doi: 10.1038/s41598-019-41053-z. PMID: 31273221; PMCID: PMC6609830.
  12. Yeh HW, Hsu EC, Lee SS, Lang YD, Lin YC, Chang CY, Lee SY, Gu DL, Shih JH, Ho CM, Chen CF, Chen CT, Tu PH, Cheng CF, Chen RH, Yang RB, Jou YS. PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis. Nat Cell Biol. 2018 Apr;20(4):479-491. doi:10.1038/s41556-018-0062-y. Epub 2018 Mar 28. PMID: 29593326.
  13. Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy JY, Liang JT, Chen RH. miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Res. 2012 Jul 15;72(14):3631-41. doi: 10.1158/0008-5472.CAN-12-0667. Epub 2012 May 16. Erratum in: Cancer Res. 2017 Dec 1;77(23):6788. doi: 10.1158/0008-5472.CAN-17-3079. PMID: 22593189.
  14. Chou HC, Lang YD, Wang LF, Wu TY, Hsieh YF, Chen CM. Angiotensin II type 1 receptor antagonist attenuates lung fibrosis in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2012 Jan;340(1):169-75. doi: 10.1124/jpet.111.186288. Epub 2011 Oct 17. PMID: 22005041.
  15. Jiang JS, Lang YD, Chou HC, Shih CM, Wu MY, Chen CM, Wang LF. Activation of the renin-angiotensin system in hyperoxia-induced lung fibrosis in neonatal rats. Neonatology. 2012;101(1):47-54. doi: 10.1159/000329451. Epub 2011 Jul 26. PMID: 21791939.
  16. Chen CM, Wu MY, Chou HC, Lang YD, Wang LF. Downregulation of caveolin-1 in a murine model of acute allergic airway disease. Pediatr Neonatol. 2011 Feb;52(1):5-10. doi: 10.1016/j.pedneo.2010.12.006. Epub 2011 Feb 18. PMID:21385650.
  17. Lang YD, Hung CL, Wu TY, Wang LF, Chen CM. The renin-angiotensin system mediates hyperoxia-induced collagen production in human lung fibroblasts. Free Radic Biol Med. 2010 Jul 1;49(1):88-95. doi: 10.1016/j.freeradbiomed.2010.03.022. Epub 2010 Mar 28. PMID: 20353822.
  18. Tung JN, Lang YD, Wang LF, Chen CM. Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts. Toxicol In Vitro. 2010 Apr;24(3):803-8. doi:10.1016/j.tiv.2009.12.015. Epub 2009 Dec 24. PMID: 20035857.
  19. Lang YD, Chang SF, Wang LF, Chen CM. Chymase mediates paraquat-induced collagen production in human lung fibroblasts. Toxicol Lett. 2010 Mar 1;193(1):19-25. doi: 10.1016/j.toxlet.2009.12.001. Epub 2009 Dec 5. PMID:19969051.
  20. Jiang JS, Chou HC, Wang LF, Lang YD, Chen CM. Effects of activated protein C on ventilator-induced lung injury in rats. Respiration. 2010;80(3):246-53. doi: 10.1159/000279438. Epub 2010 Jan 28. PMID: 20110652.
  21. Chen CM, Chou HC, Wang LF, Lang YD. Experimental oligohydramnios decreases collagen in hypoplastic fetal rat lungs. Exp Biol Med (Maywood). 2008 Nov;233(11):1334-40. doi: 10.3181/0803-RM-99. Epub 2008 Sep 12. PMID: 18791129.
  22. Chen CM, Chou HC, Wang LF, Lang YD. Captopril decreases plasminogen activator inhibitor-1 in rats with ventilator-induced lung injury. Crit Care Med. 2008 Jun;36(6):1880-5. doi: 10.1097/CCM.0b013e31817c911d. PMID: 18520644.
  23. Chen CM, Chou HC, Wang LF, Lang YD, Yeh CY. Retinoic acid fails to reverse oligohydramnios-induced pulmonary hypoplasia in fetal rats. Pediatr Res. 2007 Nov;62(5):553-8. doi: 10.1203/PDR.0b013e31815685b9. PMID: 18049370.
  24. Chen CM, Wang LF, Chou HC, Lang YD, Lai YP. Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis. Pediatr Res. 2007 Aug;62(2):128-33. doi: 10.1203/PDR.0b013e3180987202. PMID: 17597657.
  25. Chen CM, Wang LF, Lang YD. Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring. Acta Paediatr Taiwan. 2007 Mar-Apr;48(2):62-7. PMID: 17626604.
  26. Chen CM, Wang LF, Chou HC, Lang YD. Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs. Neonatology. 2007;92(3):187-93. doi: 10.1159/000102958. Epub 2007 May 21. PMID: 17519529.