藍耀東（Lang, Yaw-Dong）

藍耀東_大頭照
姓名：藍耀東（Lang, Yaw-Dong）
職稱：助理研究員
電話：02-2820-1999轉7531(Office)
E-mail : ydlang@nricm.edu.tw

學歷:
臺北醫學大學 醫學科學研究所 博士

主要經歷:
中央研究院生物化學研究所 博士後研究員
中央研究院生物醫學科學研究所 博士後研究員
中央研究院生物醫學科學研究所 專案研究員
國立陽明交通大學醫學院 博士後研究員
國立陽明交通大學腫瘤惡化卓越研究中心 助理研究員
臺北醫學大學附設醫院研究部 醫學研究員
臺北醫學大學臨床醫學研究所 兼任助理教授


學術榮譽事蹟:  
臺灣國際創新生物醫學峰會 優秀論文海報獎
第27屆細胞及分子生物新知研討會優秀論文海報獎
財團法人肝病防治學術基金會優秀論文獎
科技部108年度博士後研究人員學術研究獎

專長：
  1. 中藥輔助癌症抗藥性之多體學(Multiomics)之研究平台
  2.  中藥於癌症實驗動物模式之研究平台
  3.  中藥應用於腫瘤類器官模型之腫瘤微環境相關性研究
  4.  中藥於病人之液態切片(Liquid biopsy)之精準醫學

近期研究方向簡介:
本實驗室聚焦於癌症抗藥性、免疫逃脫與治療反應監測三大挑戰，藉由多體學整合、動物模型與液態活檢技術，探索機制並發展臨床轉譯應用。
1.中藥於癌症抗藥與轉移之機制研究:結合多體學分析與癌症動物平台，探討中藥或天然物在腫瘤抗藥性與轉移過程中的作用，並釐清外泌體與腫瘤微環境重塑的關鍵角色。
2.非小細胞肺癌免疫治療之影響:研究中藥黃芩與氧化蛋白及訊號對 PD-L1表現的調控機制，評估其在免疫檢查點抑制劑治療中的敏感性調節作用，並開發潛在的分子標誌物。
3.釔90放射栓塞治療之液態活檢應用:建立胞外體與循環游離 DNA 檢測平台，監測接受釔90 放射栓塞治療之肝膽惡性腫瘤患者的復發風險，期望發展早期預後與治療決策指標，希望透過這樣的經驗結合到精準中醫藥學的應用。
  1. Yeh HW, Lang YD (co-first), Lee HY, Jou YS. PSPC1 bridges cancer stemness and malignancy in acute yeloid leukemia. Cell Stem Cell. 2025 Mar 6;32(3):335-337. doi:10.1016/j.stem.2025.02.006. PMID: 40054451.
  2. Lin TY, Gu SY, Lin YH, Shih JH, Lin JH, Chou TY, Lee YC, Chang SF, Lang YD*. Paclitaxel-resistance facilitates glycolytic metabolism via Hexokinase-2-regulated ABC and SLC transporter genes in ovarian clear cell carcinoma. Biomed Pharmacother. 2024 Nov;180:117452. doi: 10.1016/j.biopha.2024.117452. Epub 2024 Sep 28. PMID: 39341074.
  3. Chen KJ, Huang JH, Shih JH, Gu DL, Lee SS, Shen R, Hsu YH, Kung YC, Wu CY, Ho CM, Jen HW, Lee HY, Lang YD, Hsiao CH, Jou YS. Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinoma. Mol Carcinog. 2023 Mar;62(3):348-359. doi: 10.1002/mc.23490. Epub 2022 Dec 1. PMID: 36453714; PMCID: PMC10107479.
  4. Chen HY, Chan SJ, Liu X, Wei AC, Jian RI, Huang KW, Lang YD, Shih JH, Liao CC, Luan CL, Kao YT, Chiang SY, Hsiao PW, Jou YS, Chen Y, Chen RH. Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression. J Hematol Oncol. 2022 Jul 6;15(1):85. doi: 10.1186/s13045-022-01306-3. PMID: 35794621; PMCID: PMC9258208.
  5. Lang YD, Jou YS. PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression. J Biomed Sci. 2021 Aug 2;28(1):57. doi: 10.1186/s12929-021-00753-3. PMID: 34340703; PMCID: PMC8327449.
  6. Jen HW, Gu DL, Lang YD, Jou YS. PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility. Cells. 2020 Jun 18;9(6):1490. doi:10.3390/cells9061490. PMID: 32570949; PMCID: PMC7349238.
  7. Shih JH, Chen HY, Lin SC, Yeh YC, Shen R, Lang YD, Wu DC, Chen CY, Chen RH, Chou TY, Jou YS. Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma. Nucleic Acids Res. 2020 Feb 20;48(3):1175-1191. doi:10.1093/nar/gkz1149. PMID: 31853539; PMCID: PMC7026595.
  8. Lang YD, Jou YS. PSPC1: a contextual determinant of tumor progression. Mol Cell Oncol. 2020 Feb 3;7(2):1721253. doi: 10.1080/23723556.2020.1721253. PMID: 32158931; PMCID: PMC7051164.
  9. Lang YD, Chen HY, Ho CM, Shih JH, Hsu EC, Shen R, Lee YC, Chen JW, Wu CY, Yeh HW, Chen RH, Jou YS. PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression. Nat Commun. 2019 Dec 16;10(1):5716. doi: 10.1038/s41467-019-13665-6. PMID: 31844057;PMCID: PMC6914800.
  10. Yeh HW, Lee SS, Chang CY, Lang YD, Jou YS. A New Switch for TGFβ in Cancer. Cancer Res. 2019 Aug 1;79(15):3797-3805. doi: 10.1158/0008-5472.CAN-18-2019. Epub 2019 Jul 12. PMID: 31300476.
  11. Chen HY, Lang YD, Lin HN, Liu YR, Liao CC, Nana AW, Yen Y, Chen RH. miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2. Sci Rep. 2019 Jul 4;9(1):9687. doi: 10.1038/s41598-019-41053-z. PMID: 31273221; PMCID: PMC6609830.
  12. Yeh HW, Hsu EC, Lee SS, Lang YD, Lin YC, Chang CY, Lee SY, Gu DL, Shih JH, Ho CM, Chen CF, Chen CT, Tu PH, Cheng CF, Chen RH, Yang RB, Jou YS. PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis. Nat Cell Biol. 2018 Apr;20(4):479-491. doi:10.1038/s41556-018-0062-y. Epub 2018 Mar 28. PMID: 29593326.
  13. Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy JY, Liang JT, Chen RH. miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Res. 2012 Jul 15;72(14):3631-41. doi: 10.1158/0008-5472.CAN-12-0667. Epub 2012 May 16. Erratum in: Cancer Res. 2017 Dec 1;77(23):6788. doi: 10.1158/0008-5472.CAN-17-3079. PMID: 22593189.
  14. Chou HC, Lang YD, Wang LF, Wu TY, Hsieh YF, Chen CM. Angiotensin II type 1 receptor antagonist attenuates lung fibrosis in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2012 Jan;340(1):169-75. doi: 10.1124/jpet.111.186288. Epub 2011 Oct 17. PMID: 22005041.
  15. Jiang JS, Lang YD, Chou HC, Shih CM, Wu MY, Chen CM, Wang LF. Activation of the renin-angiotensin system in hyperoxia-induced lung fibrosis in neonatal rats. Neonatology. 2012;101(1):47-54. doi: 10.1159/000329451. Epub 2011 Jul 26. PMID: 21791939.
  16. Chen CM, Wu MY, Chou HC, Lang YD, Wang LF. Downregulation of caveolin-1 in a murine model of acute allergic airway disease. Pediatr Neonatol. 2011 Feb;52(1):5-10. doi: 10.1016/j.pedneo.2010.12.006. Epub 2011 Feb 18. PMID:21385650.
  17. Lang YD, Hung CL, Wu TY, Wang LF, Chen CM. The renin-angiotensin system mediates hyperoxia-induced collagen production in human lung fibroblasts. Free Radic Biol Med. 2010 Jul 1;49(1):88-95. doi: 10.1016/j.freeradbiomed.2010.03.022. Epub 2010 Mar 28. PMID: 20353822.
  18. Tung JN, Lang YD, Wang LF, Chen CM. Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts. Toxicol In Vitro. 2010 Apr;24(3):803-8. doi:10.1016/j.tiv.2009.12.015. Epub 2009 Dec 24. PMID: 20035857.
  19. Lang YD, Chang SF, Wang LF, Chen CM. Chymase mediates paraquat-induced collagen production in human lung fibroblasts. Toxicol Lett. 2010 Mar 1;193(1):19-25. doi: 10.1016/j.toxlet.2009.12.001. Epub 2009 Dec 5. PMID:19969051.
  20. Jiang JS, Chou HC, Wang LF, Lang YD, Chen CM. Effects of activated protein C on ventilator-induced lung injury in rats. Respiration. 2010;80(3):246-53. doi: 10.1159/000279438. Epub 2010 Jan 28. PMID: 20110652.
  21. Chen CM, Chou HC, Wang LF, Lang YD. Experimental oligohydramnios decreases collagen in hypoplastic fetal rat lungs. Exp Biol Med (Maywood). 2008 Nov;233(11):1334-40. doi: 10.3181/0803-RM-99. Epub 2008 Sep 12. PMID: 18791129.
  22. Chen CM, Chou HC, Wang LF, Lang YD. Captopril decreases plasminogen activator inhibitor-1 in rats with ventilator-induced lung injury. Crit Care Med. 2008 Jun;36(6):1880-5. doi: 10.1097/CCM.0b013e31817c911d. PMID: 18520644.
  23. Chen CM, Chou HC, Wang LF, Lang YD, Yeh CY. Retinoic acid fails to reverse oligohydramnios-induced pulmonary hypoplasia in fetal rats. Pediatr Res. 2007 Nov;62(5):553-8. doi: 10.1203/PDR.0b013e31815685b9. PMID: 18049370.
  24. Chen CM, Wang LF, Chou HC, Lang YD, Lai YP. Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis. Pediatr Res. 2007 Aug;62(2):128-33. doi: 10.1203/PDR.0b013e3180987202. PMID: 17597657.
  25. Chen CM, Wang LF, Lang YD. Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring. Acta Paediatr Taiwan. 2007 Mar-Apr;48(2):62-7. PMID: 17626604.
  26. Chen CM, Wang LF, Chou HC, Lang YD. Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs. Neonatology. 2007;92(3):187-93. doi: 10.1159/000102958. Epub 2007 May 21. PMID: 17519529.