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郭曜豪（Kuo, Yao-Haur）

郭曜豪生活照姓名：郭曜豪（Kuo, Yao-Haur）
職稱：研究員
電話： 2820-1999轉7051、7061
E-mail : kuoyh@nricm.edu.tw

學歷:
中國文化大學 天然物化學 博士

主要經歷:
美國北卡羅萊納大學藥學院 藥物化學與天然物學系 博士後研究
中國文化大學 化學系與園藝學系 教授/副教授
中國醫藥大學 中西醫結合研究所 兼任教授

專長:
天然物化學，生藥學，中草藥品質管制

研究簡介:
　　我們研究室最近與一些藥理研究室合作探討具抗癌、抗血管新生、抗發炎、抗血小板凝集、抗乙型肝炎、與防治心血管與糖尿病等功能性之中草藥與真菌，從事其有效成分之分離與化學結構之鑑定工作外，且進一步將活性物質合成製備成各種衍生物以供進行動物實驗，探討化學結構與活性關係，研究其治病機轉。並將具有上述潛力的中草藥在化學成分和藥理數據的指紋圖譜監控下，進行治療性或功能性的部份純化以及粗萃取物質之研究。
目前研究室主要專注於探討
(一)部份棕櫚科與豆科植物的抗心血管與糖尿病有效成分，
(二)中草藥複方應用於治癌等研究。

論文著述:

NCBI PubMed :  Yao-Haur Kuo (Please click!!)

  1. Cheng, H.-H., Cheng, Y.-B., Hwang, T.-L., Kuo, Y.-H., Chen, C.-H., & Shen, Y.-C. (2015). Randainins A-D, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis. Journal of Natural Products. doi:10.1021/acs.jnatprod.5b00012
  2. Liaw, C.-C., Cheng, Y.-B., Lin, Y.-S., Kuo, Y.-H., Hwang, T.-L., & Shen, Y.-C. (2014). New briarane diterpenoids from Taiwanese soft coral Briareum violacea. Marine Drugs, 12(8), 4677-4692. doi:10.3390/md12084677
  3. Tsai, Y.-C., Cheng, Y.-B., Lo, I. W., Cheng, H.-H., Lin, C.-J., Hwang, T.-L., . . . Shen, Y.-C. (2014). Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera. Chemistry & Biodiversity, 11(7), 1053-1068. doi:10.1002/cbdv.201300259
  4. Zhang, L.-J., Liaw, C.-C., Hsiao, P.-C., Huang, H.-C., Lin, M.-J., Lin, Z.-H., . . . Kuo, Y.-H. (2014). Cucurbitane-type glycosides from the fruits of Momordica charantia and their hypoglycaemic and cytotoxic activities. Journal of Functional Foods, 6, 564-574. doi:10.1016/j.jff.2013.11.025
  5. Hsu, L.-C., Liang, Y.-H., Hsu, Y.-W., Kuo, Y.-H., & Pan, T.-M. (2013). Anti-inflammatory properties of yellow and orange pigments from Monascus purpureus NTU 568. Journal of Agricultural and Food Chemistry, 61(11), 2796-2802. doi:10.1021/jf305521v
  6. Huang, H.-C., Hwang, S.-Y., Liang, Y.-H., Zhang, L.-J., Hsu, Y.-W., Liaw, C.-C., & Kuo, Y.-H. (2013). Constituents from Taiwanese Sarcopyramis nepalensis. Journal of Chinese Medicine, 24(1), 1-12.
  7. Huang, H.-C., Lin, M.-K., Hwang, S.-Y., Hwang, T.-L., Kuo, Y.-H., Chang, C.-I., . . . Kuo, Y.-H. (2013). Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb. Molecules, 18(8), 8752-8763. doi:10.3390/molecules18088752
  8. Kuo, L.-M. Y., Zhang, L.-J., Huang, H.-T., Lin, Z.-H., Liaw, C.-C., Cheng, H.-L., . . . Ho, H.-O. (2013). Antioxidant lignans and chromone glycosides from Eurya japonica. Journal of Natural Products, 76(4), 580-587. doi:10.1021/np3007638
  9. Liaw, C.-C., Chen, Y.-C., Fazary, A. E., Hsieh, J.-L., Chen, S.-Y., Chien, C.-T., . . . Shen, Y.-C. (2013). A novel prenylated C6–C3 compound with estrogen-like activity from the fruits of Illicium arborescens. Phytochemistry Letters, 6(3), 397-402. doi:10.1016/j.phytol.2013.04.005
  10. Lin, Y.-C., Cheng, Y.-B., Liaw, C.-C., Lo, I. W., Kuo, Y.-H., Chiang, M. Y., . . . Shen, Y.-C. (2013). New lignans from the leaves and stems of Kadsura philippinensis. Molecules, 18(6), 6573-6583. doi:10.3390/molecules18066573
  11. Chiou, C.-T., Kuo, Y.-H., Chan, Y.-Y., Juang, S.-H., Chan, H.-H., & Wu, T.-S. (2012). Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro. Phytochemistry, 80, 64-69. doi:10.1016/j.phytochem.2012.05.005
  12. Hsu, L.-C., Hsu, Y.-W., Liang, Y.-H., Liaw, C.-C., Kuo, Y.-H., & Pan, T.-M. (2012). Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568. Molecules, 17(1), 664-673. doi:10.3390/molecules17010664
  13. Hsu, L.-C., Hsu, Y.-W., Liang, Y.-H., Lin, Z.-H., Kuo, Y.-H., & Pan, T.-M. (2012). Protective effect of deferricoprogen isolated from Monascus purpureus NTU 568 on citrinin-induced apoptosis in HEK-293 cells. Journal of Agricultural and Food Chemistry, 60(32), 7880-7885. doi:10.1021/jf301889q
  14. Hsu, Y.-S., Kuo, Y.-H., Cheng, H.-L., Flatt, P. R., & Liu, H.-K. (2012). Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells. World Journal of Gastroenterology, 18(46), 6809-6818. doi:10.3748/wjg.v18.i46.6809
  15. Huang, C.-Y., Su, J.-H., Duh, C.-Y., Chen, B.-W., Wen, Z.-H., Kuo, Y.-H., & Sheu, J.-H. (2012). A new 9,11-secosterol from the soft coral Sinularia granosa. Bioorganic & Medicinal Chemistry Letters, 22(13), 4373-4376. doi:10.1016/j.bmcl.2012.05.002
  16. Huang, H.-C., Chiou, C.-T., Hsiao, P.-C., Liaw, C.-C., Zhang, L.-J., Chang, C.-L., . . . Kuo, Y.-H. (2012). Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai. Molecules, 17(2), 1837-1851. doi:10.3390/molecules17021837
  17. Kuo, Y.-H., Hsu, H.-C., Chen, Y.-C., Liang, T.-W., & Wang, S.-L. (2012). A Novel Compound with Antioxidant Activity Produced by Serratia ureilytica TKU013. Journal of Agricultural and Food Chemistry, 60(36), 9043-9047. doi:10.1021/jf302481n
  18. Lee, I. J., Huang, P.-C., Zhang, L.-J., Liaw, C.-C., Lin, M.-R., Yu, C.-J., . . . Kuo, Y.-H. (2012). Investigation of Two Species of (Aatragalus membranaceus and Hedysarum polybotrys) by HPLC, ITS, Microscopic Morphology and Antioxidant Activities. Journal of Food and Drug Analysis, 20(3), 603-610. doi:10.6227/jfda.2012200306
  19. Lin, W.-Y., Lu, Y., Chen, B.-W., Huang, C.-Y., Su, J.-H., Wen, Z.-H., . . . Sheu, J.-H. (2012). Sarcocrassocolides M-O, bioactive cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule. Marine Drugs, 10(3), 617-626. doi:10.3390/md10030617
  20. Shen, C.-C., Hong, K.-Y., Chen, J., Zhang, L.-J., Lin, Z.-H., Huang, H.-T., . . . Kuo, Y.-H. (2012). Antioxidant and anti-nitric oxide components from Quercus glauca. Chemical & Pharmaceutical Bulletin, 60(7), 924-929. doi:10.1248/cpb.c12-00174
  21. Zhang, L.-J., Cheng, J.-J., Liao, C.-C., Cheng, H.-L., Huang, H.-T., Kuo, L.-M. Y., & Kuo, Y.-H. (2012). Triterpene Acids from Euscaphis japonica and Assessment of Their Cytotoxic and Anti-NO Activities. Planta Medica, 78(14), 1584-1590. doi:10.1055/s-0032-1315040
  22. Cheng, Y.-B., Lin, Y.-C., Khalil, A. T., Liou, S.-S., Lee, G.-C., Kuo, Y.-H., & Shen, Y.-C. (2011). Seven new lignan esters from Kadsura philippinensis. Helvetica Chimica Acta, 94(1), 148-158. doi:10.1002/hlca.201000156
  23. Hsu, L.-C., Hsu, Y.-W., Liang, Y.-H., Kuo, Y.-H., & Pan, T.-M. (2011). Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from Monascus purpureus NTU 568. Journal of Agricultural and Food Chemistry, 59(4), 1124-1130. doi:10.1021/jf103652n
  24. Hsu, Y.-W., Hsu, L.-C., Liang, Y.-H., Kuo, Y.-H., & Pan, T.-M. (2011). New bioactive orange pigments with yellow fluorescence from Monascus-fermented dioscorea. Journal Agricultural and Food Chemistry, 59(9), 4512-4518. doi:10.1021/jf1045987
  25. Juan, Y.-C., Kuo, Y.-H., Chang, C.-C., Zhang, L.-J., Lin, Y.-Y., Hsu, C.-Y., & Liu, H.-K. (2011). Administration of a decoction of sucrose- and polysaccharide-rich Radix Astragali (Huang Qi) ameliorated insulin resistance and fatty liver but affected beta-cell function in type 2 diabetic rats. Evidence-Based Complementary and Alternative Medicine. doi:10.1093/ecam/nep238
  26. Kuo, Y.-H., Liang, T.-W., Liu, K.-C., Hsu, Y.-W., Hsu, H.-C., & Wang, S.-L. (2011). Isolation and identification of a novel antioxidant with antitumour activity from Serratia ureilytica using squid pen as fermentation substrate. Marine Biotechnology, 13(3), 451-461. doi:10.1007/s10126-010-9316-9
  27. Liaw, C.-C., Kuo, Y.-H., Lin, Y.-S., Hwang, T.-L., & Shen, Y.-C. (2011). Frajunolides L–O, four new 8-hydroxybriarane diterpenoids from the gorgonian Junceella fragilis. Marine Drugs, 9(9), 1477-1486. doi:10.3390/md9091477
  28. Lin, W.-Y., Lu, Y., Su, J.-H., Wen, Z.-H., Dai, C.-F., Kuo, Y.-H., & Sheu, J.-H. (2011). Bioactive cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule. Marine Drugs, 9(6), 994-1006. doi:10.3390/md9060994
  29. Lin, Y.-S., Fazary, A. E., Chen, C.-H., Kuo, Y.-H., & Shen, Y.-C. (2011). Asterolaurins G–J, new xenicane diterpenoids from the Taiwanese soft coral Asterospicularia laurae. Helvetica Chimica Acta, 94(2), 273-281. doi:10.1002/hlca.201000192
  30. Lin, Y.-S., Fazary, A. E., Chen, C.-H., Kuo, Y.-H., & Shen, Y.-C. (2011). Bioactive xenicane diterpenoids from the Taiwanese soft coral Asterospicularia laurae. Chemistry & Biodiversity, 8(7), 1310-1317. doi:10.1002/cbdv.201000173
  31. Shen, Y.-C., Chang, Y.-T., Lin, C.-L., Liaw, C.-C., Kuo, Y.-H., Tu, L.-C., . . . Chern, J.-W. (2011). Synthesis of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-β-carboline analogs as potential antitumor agents. Marine Drugs, 9(2), 256-277. doi:10.3390/md9020256
  32. Shi, L.-S., Chao, C.-H., Shen, D.-Y., Chan, H.-H., Chen, C.-H., Liao, Y.-R., . . . Lee, K.-H. (2011). Biologically active constituents from the fruiting body of Taiwanofungus camphoratus. Bioorganic & Medicinal Chemistry, 19(1), 677-683. doi:10.1016/j.bmc.2010.10.032
  33. Thang, T. D., Kuo, P.-C., Yu, C.-S., Shen, Y.-C., Thanh, T. V., Kuo, Y.-H., . . . Wu, T.-S. (2011). Chemical constituents of the leaves of Glochidion obliquum and their bioactivity. Archives of Pharmacal Research, 34(3), 383-389. doi:10.1007/s12272-011-0305-y
  34. Wu, C.-L., Kuo, Y.-H., Lee, C.-L., Hsu, Y.-W., & Pan, T.-M. (2011). Synchronous high-performance liquid chromatography with a photodiode array detector and mass spectrometry for the determination of citrinin, monascin, ankaflavin, and the lactone and acid forms of monacolin K in red mold rice. Journal of AOAC International, 94(1), 179-190.
  35. Zhang, L.-J., Liu, H.-K., Hsiao, P.-C., Kuo, Y.-L.-M., Lee, I. J., Wu, T.-S., . . . Kuo, Y.-H. (2011). New isoflavonoid glycosides and related constituents from Astragali Radix (Astragalus membranaceus) and their inhibitory activity on nitric oxide production. Journal of Agricultural and Food Chemistry, 59(4), 1131-1137. doi:10.1021/jf103610j
  36. Zhang, L.-J., Yeh, S.-F., Yu, Y.-T., Kuo, L.-M. Y., & Kuo, Y.-H. (2011). Antioxidative flavonol glucuronides and anti-HBsAg flavonol from Rotala rotundifolia. Journal of Traditional and Complementary Medicine, 1(1), 57-63. doi:10.6219/jtcm.2011.004-OY.C. Juan, Y.H. Kuo, C.C. Chang, L.J. Zhang, Y.Y. Lin, C.Y. Hsu and H.K. Liu, Administration of a decoction of sucrose- andpolysaccharide-rich Radix Astragali (Huang Qi) ameliorated insulinresistance and fatty liver but affected beta cell function in type 2 diabetic rats. Evidence-Based Complementary and Alternative Medicine. (2011, on line) (SCI)
  37. J.Y Chang, M.H. Abd El-Razek, Y.H. Chen, Y.B. Cheng, S.Y. Chen, C.T. Chien, Y.H. Kuo, Y.C. Shen. Phytoquinoids and Seco-Prezizaane-Type Sesquiterpenes from Illicium arborescens, Helv. Chim. Acta. (In press). (SCI)
  38. T.W. Liang, Y.H. Kuo, P.C. Wu, C.L. Wang, N.A. Dzung, S.L. Wang, Purification and characterization of a chitosanase and a protease by conversion of shrimp shell wastes fermented by Serratia marcescens subsp. sakuensis TKU019. Journal of the Chinese Chemical Society, 57, 857-863 (2010). (SCI)
  39. Y.J. Kuo, Y.C. Yang, L.J. Zhang, M.D. Wu, L.M.Yang Kuo, Y.C. Kuo, C.J. Chou, K.H. Lee, H.O. Ho* and Y.H. Kuo*, Flavanone and Diphenylpropane Glycosides and Glycosidic Acyl Esters from Viscum articulatum. J. Nat. Prod. 73, 109-114 (2010). (SCI)
  40. C.L. Chang, L.J. Zhang, R.Y. Chen, C.C. Wu, H.C. Huang, M.C. Roy, J.P. Huang, Y.C. Wu* and Y.H. Kuo*, Quiquelignan A–H, eight new lignoids from the rattan palm Calamus quiquesetinervius and their antiradical, anti-inflammatory and antiplatelet aggregation activities, Bioorg. & Med. Chem.18, 518-525 (2010). (SCI)
  41. S.L. Wang, K.C. Liu, T.W. Liang, Y.H. Kuo, J.Y. Wang, In vitro antioxidant activity of liquor and semi-purified fractions from squid pen biowaste by Serratia ureilytica TKU013, Food Chemistry,119,1380-1385 (2010). (SCI)
  42. C.L. Chang, G.J. Wang , L.J. Zhang , W.J. Tsai , R.Y. Chen, Y.C. Wu*, and Y.H. Kuo*, Cardiovascular protective flavonolignans and flavonoids from Calamus quiquesetinervius, Phytochemistry, 71, 271-279 (2010). (SCI)
  43. Y. Lu, J.H. SU, C.Y. Huang, Y,C, Liu, Y.H. Kuo, Z.H. Wen, C.H. Hsu, and J.H.  Sheu*, Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis, Chem. Pharm. Bull. 58, 464- 466 (2010). (SCI)
  44. W.Y. Lin, J.H. Su, Y. Lu, Z.H. Wen, C.F. Dai, Y.H. Kuo, J.H. Sheu, Cytotoxic and anti-inflammatory cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule, Bioorg. & Med. Chem.18, 1936–1941. (2010). (SCI)
  45. C.C. Liu, M.H. Abd El-Razek, C.C. Liaw, Y.B. Cheng, C. K. Chen, C. T. Chien, Y.H. Kuo, S.S. Liou, Y.C. Shen, Arisanschinins A–E, Lignans from Schisandra arisanensis Hay, Planta Med. 76, 1-6 (2010). (SCI)
  46. Y. Lu, Y.C. Lin, Z.H. Wen, SJ.H. Su, P.J. Sung, C.H. Hsu, Y.H. Kuo, M.Y. Chiang, C.F. Dai, J.H. Sheu, Steroid and cembranoids from the Dongsha atoll soft coral Lobophytum sarcophytoides, Tetrahedron, 66, 36, 7129-7135 (2010). (SCI)
  47. P.M. Chao, Y.H. Kuo, Y.S. Lin, C.H. Chen, S.W. Chen, and Y.H. Kuo, The Metabolic Benefits of Polygonum hypoleucum Ohwi in HepG2 Cells and Wistar Rats under Lipogenic Stress, J. Agric. Food Chem. 58, 5174–5180 (2010). (SCI)
  48. L.J. Zhang, C.T. Chiou,  J.J. Cheng, H.C. Huang, L.M. Yang Kuo, C.C. Liao,  K.F. Bastow,  K.H. Lee and Y.H. Kuo*, Cytotoxic Polyisoprenyl Benzophenonoids from Garcinia subelliptica, J. Nat. Prod. 73, 557-562 (2010). (SCI)
  49. B.Y. Ho, Y.M. Wu, Y.W. Hsu, L.C. Hsu, Y.H. Kuo, K.J. Chang, and T.M. Pan, Effects of Monascus-Fermented Rice Extract on Malignant Cell–Associated Neovascularization and Intravasation Determined Using the Chicken Embryo Chorioallantoic Membrane Model, Integr. Cancer Ther. 9, 204-212 (2010).(SCI)
  50. Y.X. Lin, A. E. Fazary, S.Y. Chen, C.T. Chien, Y.H. Kuo, S.Y. Sheu and Y.C. Shen, Illicaborins A-C, Three Prenylated C6-C3 Compounds from the Fruits of Illicium arborescens, Food Chemistry 123, 1105-1111 (2010). (SCI)
  51. T.L. Hwang, C.C. Wang, Y.H. Kuo, H.C. Huang, Y.C. Wu, L.M. Kuo, and Y.H. Wu, The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation, Biochemical Pharmacol. 80, 1190-1200 (2010). (SCI)
  52. Y.W. Hsu, L.C. Hsu, Y.H. Liang, Y.H. Kuo* and T.M. Pan*, Monaphilones A-C, Three New Antiproliferative Azaphilone Derivatives from Monascus purpureus NTU 568, J. Agric. Food Chem. 58, 8211–8216 (2010). (SCI)
  53. J.J. Cheng, L.J. Zhang, H.L. Cheng, C.T. Chiou, I.J. Lee and Y.H. Kuo,* Cytotoxic Hexacyclic Triterpene acids from Euscaphis japonica, J. Nat. Prod. 73, 1655–1658 (2010). (SCI)
  54. Y.C. Shen, K.L. Lo, J.Y. Chang, Y.S. Lin, K. Mendbayar, Y.H. Kuo, Y.C. Lin, New cytotoxic prostanoids from Taiwanese soft coral Clavularia viridis. Chem Biodivers. 7, 2702-8 (2010). (SCI)
  55. C.L. Chang, L.J. Zhang, R.Y. Chen, L.M. Yang Kuo, J.P. Huang, H.C. Huang, K.H. Lee, Y.C. Wu* and Y.H. Kuo,*  Antioxidant and Anti-inflammatory Phenylpropanoid Derivatives from Calamus quiquesetinervius, J. Nat. Prod. 73, 1482–1488 (2010). (SCI)
  56. Y.W. Hsu, L.C. Hsu, C.L. Chang, Y.H. Liang, T.M. Pan* and Y.H. Kuo,*  New anti-inflammatory and anti-proliferative constituents from fermented red mold rice Monascus purpureus NTU 568, Molecules 11, 7815-7824 (2010). (SCI)
  57. Y.B. Cheng, C.Y. Chen, Y.H. Kuo, and Y.C. Shen, New Nitrogen-Containing Sesquiterpenoids from the Taiwanese Soft Coral Cespitularia taeniata May, Chem. & Biodiv. 6, 1266-1272 (2009). (SCI)
  58. S.S. Wang, M.H. Abd El-Razek, Y.C. Chen, C.T. Chien, J.H. Guh, Y.H. Kuo and Y.C. Shen, abeo-taxane diterpenoids from the Taiwanese Yew Taxus sumatrana, Chem Biodivers. 6, 2255-62 (2009) (SCI)
  59. T.D. Thang, P.C. Kuo, N.X. Luong, N.X. Dung, L.V. Hac, Y.H. Kuo, M.L. Yang and T.S. Wu, Chemical Constituents from the Leaves of Xylopia poilanei and Their Bioactivity, Heterocycles 78, 763-770 (2009). (SCI)
  60. S.Y Huang, L.Y. Fan, Y.C. Shen, C.C. Liao, L.C. Hsu, Y.W. Hsu, T.S. Wu, P. C. Hsiao, C.C. Shen, M.J. Don and Y.H. Kuo*,  A New Dimeric phenylpropanoid and Cytotoxic Norditerpene Constituents from Podocarpus nakaii. J. Asian. Nat. Prod. Res. 11, 410–416 (2009). (SCI)
  61. S.L. Wu, J.H. Su, Z.H. Wen, C.H. Hsu, B.W. Chen, C.F. Dai, Y.H. Kuo and J.H. Sheu, Simplexins A-I, Eunicellin-Based Diterpenoids from the Soft Coral,  Klyxum simplex, J. Nat. Prod. 72, 994–1000 (2009). (SCI)
  62. Y.H. Kuo, W.J. Tsai, S.H. Loke, T.S. Wu and W.F. Chiou, Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming, J. Ethnopharmacol. 122, 28–34 (2009). (SCI)
  63. Y.Y. Chan, T.S. Wu and Y.H. Kuo, Chemical Constituents and Cytotoxicity from the Stem Bark of Citrus medic,. Heterocycles, 78, 1309-1316 (2009). (SCI)
  64. Y.J. Kuo, P.C. Hsiao, L.J. Zhang, M.D. Wu, Y.H. Liang, H.O. Ho, and Y.H. Kuo*, Labdane Diterpenoid Glycosides from Alpinia densespicata and Their Nitric Oxide Inhibitory Activities in Macrophages, J. Nat. Prod. 72, 1097–1101 (2009) (SCI).
  65. L.J. Luh, M. H. A. El-Razek, C.C. Liaw, C.T. Arthur Chen, Y.S. Lin, Y.H. Kuo, C.T. Chien, and Y.C. Shen. Tri- and Bicyclic Taxoids from the Taiwanese Yew Taxus sumatrana. Helv. Chim. Acta. 92, 1349-1359 (2009). (SCI)
  66. H.C. Huang, C.H. Chao, Y.H. Kuo, and J.H. Sheu, Crassocolides G-M, Cembranoids from Formosan Soft Coral Sarcophyton crassocaule, Chem. & Biodiv. 6, 1232-1242 (2009). (SCI)
  67. Y.C. Shen, P.S. Shih, Y.S. Lin, Y.C. Lin, Y.H. Kuo, Irciformonins E-K, C22-Trisnorsesterterpenoids from the Sponge Ircinia formosana. Helv. Chim. Acta 92, 10, 2101-2110 (2009) (SCI)
  68. K.L. Lo, A.T. Khalil, Y.H. Kuo, and Y.C. Shen,  Sinuladiterpenes A-F, Cembrane Diterpenes from Sinularia flexibilis, Chem. & Biodiv. 6, 12, 2227-2235 (2009). (SCI)
  69. Y.S. Lin, C.H. Chan, C.C. Liaw, Y.C. Chen, Y.H. Kuo, Y.C. Shen, Cembrane diterpenoids from the Taiwanese soft coral Sinularia flexibilis, Tetrahedron, 65, 9157-9164 (2009). (SCI)
  70. S.L. Wang, Lin C.L. Lin, T.W. Liang, K.C. Liu, Y.H. Kuo, Conversion of squid pen by Serratia ureilytica for the production of enzymes and antioxidants, Bioresou. Technol. 100, 316–323 (2009). (SCI)
  71. Y.B. Cheng, M.T. Chang, Y.W. Lo, C.J. Ho, Y.C. Kuo, C.T. Chien, S.Y. Chen, S.S. Liou, Y.H. Kuo, and Y.C. Shen, Oxygenated Lignans from the Fruits of Schisandra arisanensis, J. Nat. Prod. 72, 1663-1668 (2009). (SCI)
  72. H.C. Huang, C.C. Liaw, L.J. Zhang, H.U. Ho,L.M.Yang Kuo,Y.C. Shen and Y.H. Kuo,* Triterpenoid saponins from Hydrocotyle sibthorpioides, Phytochemistry 69, 1597-1603 (2008). (SCI)
  73. H.C. Huang, M.D. Wu, W.J. Tsai, S.C. Liao, L.C. Hsu, Y.C. Wu* and Y.H. Kuo,* Triterpenoid saponins from the fruits and galls of Sapindus mukorossi, Phytochemistry 69,1609-1616 (2008). (SCI)
  74. Y.C.  Shen, K.L. Lo, Y.H. Kuo, Y.C. Kuo, C.H. Chen, and A.T. Khalil, Cespihypotins Q−V, Verticillene Diterpenoids from Cespitularia hypotentaculata. J. Nat. Prod., 71, 1993-1997 (2008). (SCI)
  75. Y.J. Kuo, S.Y. Hwang, M.D. Wu, C.C. Liao, Y.H. Liang, H.O. Ho and Y.H. Kuo,*   Cytotoxic Constituents from Podocarpus fasciculus. Chem. Pharm. Bull. 56, 4, 585-588 (2008). (SCI)
  76. Y.C. Shen, S.S. Wang, C.T. Chien, Y.H. Kuo, A. Khalil, Tasumatrols U-Z, Taxane Diterpene Esters from Taxus sumatrana, J. Nat. Prod. 71, 576-580 (2008). (SCI)
  77. L.J. Zhang, Y.T. Yu, C.C. Liao, H.C. Huang, Y.C. Shen, Y.H. Kuo,*  Antioxidant Phenylpropanoid Glycosides from Smilax bracteata, Phytochemistry 69, 1398-1404 (2008). (SCI)
  78. C.Y. Chen, Y.B. Cheng, S.Y. Chen, C.T. Chien, Y.H. Kuo, J.H. Guh, A.T. Khalii and Y.C. Shen, New Bioactive Clerodane from the Roots of Casearia membranacea, Chemistry & Biodiversity 5, 162-167 (2008).(SCI)
  79. Y. Lu, C.Y. Huang, Y.F. Lin, Z.H. Wen, J.H. Su, Y.H. Kuo, M.Y. Chiang, and J.H. Sheu, Anti-inflammatory Cembranoids from the Soft Corals Sinularia querciformis and Sinularia granosa,J. Nat. Prod. 71, 1754–1759 (2008). (SCI)
  80. Y.B. Cheng, Y.C. Shen, Y.H. Kuo and A.T. Khalil, Cembrane Diterpenoids from the Taiwanese Soft Coral Sarcophyton stolidotum, J. Nat. Prod. 71, 1141–1145 (2008). (SCI)
  81. M.D. Wu, M.J. Cheng, B.C. Wang, Y.Y. Yech, J.T. Lai, Y.H. Kuo, G.F. Yuan and I.S. Chen, Maleimide and Maleic Anhydride Derivatives from the Mycelia of Antrodia cinnamomea and Their Nitric Oxide Inhibitory Activities in Macrophages, J. Nat. Prod. 71, 1258–1261(2008). (SCI)
  82. C.C. Liaw, Y.H. Kuo, T.L. Hwang and Y.C. Shen, Eupatozansins A-C, Sequiterpene Lactones from Eupatorium chinense vat. tozanense. Helvetica Chimica Acta. 91, 2115-2121 (2008). (SCI)
  83. J.H. Su, C.H. Hsieh, C.L. Lo, C.Y. Huang, C.F. Dai, Y.H. Kuo and J.H. Sheu, Sesquiterpenoids-related Metabolites from the Soft Coral Sinularia sp., J. Chin. Chem. Soc., 55, 1286-1289 (2008) (SCI).
  84. Y.C. Shen, Y.C. Lin, A.F. Ahmed, Y.C. Cheng, C.C. Liaw and Y.H. Kuo. Four New Nonaoxygenated C18 Dibenzocyclooctadiene Lignans from Kadsura philippinensis, Chem. Pharm. Bull. 55, 280-283 (2007). (SCI).
  85. Y.C. Shen, S.Y. Cheng,. Y.H. Kuo, T.L. Hwang, M.Y. Chiang, and A. T. Khalil. Chemical Transformation and Biological Activities of Ambrein, a Major Product of Ambergris from Physeter macrocephalus (Sperm Whale), J. Nat. Prod. 70, 147-153 (2007) (SCI)
  86. H.C. Huang, W.J. Tsai, C.C. Liaw, Y.C.Wu and Y.H. Kuo,* Anti-platelet Aggregation Triterpene Saponins from the Galls of Sapindus mukorossi. Chem. Pharm. Bull. 55, 1412-1415 (2007). (SCI)
  87. Y.C. Shen, Y.B. Cheng, T.W. Lan, C.C. Liaw, S.S. Liou, Y.H. Kuo and A.T. Khalil, Kadsuphilols A-H, Oxygenated Lignans from Kadsura philippinensis, J. Nat. Prod. 70, 1139-1145 (2007). (SCI)
  88. Y.H. Chen., F.R. Chang., C.C. Wu, M.H. Yen, C.C. Liaw, H.C. Huang, Y.H. Kuo, Y.C. Wu, New Cytotoxicity 6-Oxygenated 8,9- dihydrofurocoumarins, Hedyotiscone A-C, from Hedyotis biflora, Planta Med. 72, 75-78 (2006). (SCI)
  89. Y.B. Cheng, J.Y. Jang, A.T. Khalil, Y.H. Kuo, Y.C. Shen, Xenicane-Type Diterpenes with Cytotoxicity from Xenia florida, J. Nat. Prod. 69, 675-678 (2006). (SCI)
  90. Y.C. Shen, C.J. Ho, Y.H. Kuo, Y.S. Lin, Cespitulactones A and B, New Diterpenoids from Cespitularia taenata, Bioorg. Med. Chem. Lett. 16, 2369-2372 (2006). (SCI)
  91. H.C. Huang, Z.H. Wen, C.H. Chao, Atallah F. Ahmed, Michael Y. Chiang, Y.H. kuo, C.H. Hsu and J.H. Sheu. Novel  sesquiterpenoids  from  the  Formosan  soft  coral  Paralemnalia thyrsoides, Tetrahedron Lett., 47, 8751-8755 (2006). (SCI)
  92. Y.C. Shen, C.C. Liaw, J.R. Ho, A.T. Khalil, Y.H. Kuo*, Isolation of Aureole from Smenospongia sp. and Cytotoxic Activity of Some Aureole Derivatives, Nat. Prod, Res. 20, 578-585 (2006). (SCI)
  93. C.Y. Kuo, M.J. Wu. Y.H. Kuo. Synthesis and antitumor activity of cis- dichloroplatinum(II) Complexes of 1-(2-aminophenyl)-1,2,3,4-tetrahdyro- isoquinolines, Eur. J. Med. Chem. 41, 940-949 (2006). (SCI)
  94. H.C. Huang, W.J. Tsai, S.L. Morris-Natschke, H. Tokuda, K.H. Lee, Y.C. Wu, Y.H. Kuo,* Sapinmusaponins F-J, Bioactive Tirucallane-Type Saponins from the galls of Sapindus mukorossi, J. Nat. Prod. 69, 763-767 (2006). (SCI)
  95. Y.C. Shen, C.C. Liaw, Y.B. Cheng, A. F. Ahmed, M.C. Lai, S.S. Liou, T.S. Wu, Y.H. Kuo, and Y.C. Lin. C18 Dibenzocyclooctadiene Lignans from Kadsura philippinensis, J. Nat. Prod. 69, 963 – 966 (2006). (SCI)
  96. J.H. Su, Atallah F .Ahmed, P.J. Sung, C. H. Chao, Y.H. Kuo and J.H. Sheu. ManaarenolidesA-I, Diterpenoids from the Soft Coral Sinularia manaarenolides, J. Nat. Prod. 69,1134-1139 (2006). (SCI)
  97. Kuo, Y.H.*, Wu, M.D., Hung, C.C., Huang, R.L., Yang Kuo, L.M., Shen, Y.C., and Ong, C.W. (2005) Syntheses of C18 dibenzocyclooctadiene lignan derivatives as anti-HBsAg and anti-HBeAg agents. Bioorg. Med. Chem., 13, 1555-1561.
  98. Hung, C.C., Tsai, W.J., Yang Kuo, L.M., and Kuo, Y.H.* (2005) Evaluation of caffeic acid amide analogues asanti-platelet aggregation and antioxidative agents. Bioorg. Med. Chem., 13, 1791-1797.
  99. Kuo, Y.H.*, Hsu, Y.W., Liaw, C.C., Lee, J.K., Huang, H.C., and Yang Kuo, L.M. (2005) New cytotoxic phenylpropanoid glycosides from the stems of Smilax china. J. Nat. Prod., 68, 1475-1478.

*: corresponding author

1. Y.H. Kuo, M.L. King. Antitumor drugs from secondary metabolites of higher plants. In : C. Tringali (ed.), Bioactive Compounds from Natural Sources, London, Taylor & Francis, 191-281 (2001).

 

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