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Associate Research Fellow/Shen, Chien-Chang

沈建昌實驗室生活照Current position:Associate Research Fellow
Telephone:866-2-2820-1999 Ext. 8581、8571
Major Professional Experiences
Postdoctoral fellow in Department of Chemistry, Ohio State University, USA
Organic Chemistry, Drug Design and Synthesis, Natural Product Chemistry
Research Description
Traditional Chinese medicine has been used for thousands of years and much precious knowledge and experience were accumulated after the long-term clinical tests. In addition to the traditional Chinese medicine described in the ancient books and records, many kinds of folk medicine are also widely used. In order to seek the effective treatments for many diseases, not only oriental countries actively investigate Chinese herbal medicine, but western countries pay more and more attention to the study of Chinese herbal medicine. Currently, our research efforts focus on the synthesis of biologically active natural products isolated from medicinal plants. Structure modification and drug design are also involved to investigate their structure-activity relationships, which may bring about the discovery of lead compounds for the treatments of diseases. Furthermore, we are interested in the study on the isolation and structure determination of natural products from medicinal plants.
Published Papers
NCBI PubMed :  Chien-Chang Shen (Please click!!)

  1. Alimboyoguen, A. B., Kathlia, A. D. C.-C., Shen, C.-C., Li, W.-T., & Ragasa, C. Y. (2014). Chemical constituents of the bark of Aleurites moluccana L. Willd. Journal of Chemical & Pharmaceutical Research, 6(5), 1318-1320.
  2. Espineli, D. L., Agoo, E. M. G., Shen, C. C., & Ragasa, C. Y. (2014). Chemical Constituents of Cinnamomum trichophyllum. Chemistry of Natural Compounds, 50(2), 389-390. doi:10.1007/s10600-014-0964-2
  3. Ragasa, C. Y., Torres, O. B., Shen, C. C., Bernardo, L. O., Mandia, E. H., K, A. D. C.-C., & Tsai, P. W. (2014). Chemical Constituents of Ficus linearifolia and Ficus triangularis. Chemistry of Natural Compounds, 50(1), 172-174.  doi:10.1007/s10600-014-0904-1
  4. Espineli, D. L., Agoo, E. M. G., Shen, C. C., & Ragasa, C. Y. (2013). Chemical Constituents of Cinnamomum iners. Chemistry of Natural Compounds, 49(5), 932-933. doi:10.1007/s10600-013-0783-x
  5. Espineli, D. L., Agoo, E. M. G., Shen, C. C., & Ragasa, C. Y. (2013). Chemical Constituents of Cinnamomum utile. Chemistry of Natural Compounds, 49(4), 769-770. doi:10.1007/s10600-013-0738-2
  6. Hsiao, P.-C., Liaw, C.-C., Hwang, S.-Y., Cheng, H.-L., Zhang, L.-J., Shen, C.-C., . . . Kuo, Y.-H. (2013). Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia. Journal of Agricultural and Food Chemistry, 61(12), 2979-2986. doi:10.1021/jf3041116
  7. Li, W.-T., Yeh, T.-K., Song, J.-S., Yang, Y.-N., Chen, T.-W., Lin, C.-H., . . . Chen, C.-T. (2013). BPR0C305, an orally active microtubule-disrupting anticancer agent. Anti-Cancer Drugs, 24(10), 1047-1057. doi:10.1097/CAD.0000000000000014
  8. Lin, P.-C., Shen, C.-C., Liao, C.-K., Jow, G.-M., Chiu, C.-T., Chung, T.-H., & Wu, J.-C. (2013). HYS-32, a novel analogue of combretastatin A-4, enhances connexin43 expression and gap junction intercellular communication in rat astrocytes. Neurochemistry International, 62(6), 881-892. doi:10.1016/j.neuint.2013.02.027
  9. Yu, H.-J., Shen, C.-C., Yi, H.-M., Chen, T.-H., Hsueh, M.-L., Lin, C.-C., & Don, M.-J. (2013). Euphorbiane: A novel triterpenoid with an unprecedented skeleton from Euphorbia tirucalli. Journal of the Chinese Chemical Society, 60(2), 191-194. doi:10.1002/jccs.201200290
  10. Chen, H.-J., Shen, Y.-C., Lin, C.-Y., Tsai, K.-C., Lu, C.-K., Shen, C.-C., & Lin, Y.-L. (2012). Metabolomics study of Buyang Huanwu Tang Decoction in ischemic stroke mice by 1H NMR. Metabolomics, 8(5), 974-984. doi:10.1007/s11306-011-0394-0
  11. Consolacion, Y. R., Dinah, L. E., & Shen, C. C. (2012). A new triterpene from Barringtonia asiatica. Natural Product Research, 26(20), 1869-1875. doi:10.1080/14786419.2011.619187
  12. Kai, L., Shen, C.-C., Lin, C.-F., Li, S.-Y., & Huang, Y.-L. (2012). A Phenolic Derivative and Two Diacetylenes from Symphyotrichum subulatum. Planta Medica, 78(16), 1780-1783. doi:10.1055/s-0032-1315372
  13. Lin, C.-F., Chen, C.-C., Shen, C.-C., Chui, C.-H., & Huang, Y.-L. (2012). Simultaneous Determination of Resveratrol Derivatives in Vitis thunbergii Plant by High Performance Liquid Chromatography. Journal of Food and Drug Analysis, 20(2), 495-500. doi:10.6227/jfda.2012200210
  14. Pai, H.-C., Chang, L.-H., Peng, C.-Y., Chang, Y.-L., Chen, C.-C., Shen, C.-C., . . . Pan, S.-L. (2012). Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway. Journal of Molecular Medicine, 91(3), 347-356. doi:10.1007/s00109-012-0945-5
  15. Shen, C.-C., Cheng, J.-J., Lay, H.-L., Wu, S.-Y., Ni, C.-L., Chen, C.-C., & Teng, C.-M. (2012). Cytotoxic apigenin derivatives from Chrysopogon aciculatis. Journal of Natural Products, 75(2), 198-201. doi:10.1021/np2007796
  16. Shen, C.-C., Hong, K.-Y., Chen, J., Zhang, L.-J., Lin, Z.-H., Huang, H.-T., . . . Kuo, Y.-H. (2012). Antioxidant and anti-nitric oxide components from Quercus glauca. Chemical & Pharmaceutical Bulletin, 60(7), 924-929. doi:10.1248/cpb.c12-00174
  17. Weng, T.C., Shen, C.C., Chiu, Y.T., Lin, Y.L., Huang, Y.T. (2012) Effects of armepavine against hepatic fibrosis induced by thioacetamide in rats. Phytother. Res., 26:344–353.
  18. Chiou, W.-F., Shen, C.-C., & Lin, L.-C. (2011). Anti-inflammatory principles from Balanophora laxiflora. Journal of Food and Drug Analysis, 19(4), 502-508.
  19. Dennis, D. R., Rafael, A. E., Shen, C.-C., & Consolacion, Y. R. (2011). A bioactive sesquiterpene from Bixa orellana. Journal of Natural Medicines, 65(1), 206-211. doi:10.1007/s11418-010-0459-9
  20. Ragasa, C. Y., Espineli, D. L., & Shen, C.-C. (2011). New triterpenes from Barringtonia asiatica. Chemical & Pharmaceutical Bulletin, 59(6), 778-782. doi:10.1248/cpb.59.778
  21. Sonia, D. J., Eunice Alexis, C. C., Montuno, A. S., Shen, C.-C., Dinah, L. E., & Consolacion, Y. R. (2011). Cytotoxic cardenolide and sterols from Calotropis gigantea. Natural Product Communications, 6(6), 803-806.
  22. Chang, J.M., Shen, C.C., Huang, Y.L., Shieh, B.J., Chen, C.C. (2010) Two new glycosides from Leonurus japonicus. J. Asian Nat. Prod. Res., 12:740–744.
  23. Shen, C.C., Wang, Y.H., Chang, T.T., Lin, L.C., Don, M.J., Hou, Y.C., Liou,K.T., Chang, S., Wang, W.Y.,Ko, H.C., and Shen, Y.C. (2007) Anti-inflammatory ergostanes from the basidiomata of Antrodia salmonea.Planta Med., 73, 1208-1213.
  24. Shen, C.C., Shen, Y.C., Wang, Y.H., Lin, L.C., Don, M.J., Liou, K.T., Wang, W.Y., Hou, Y.C., and Chang, T.T.(2006) New Lanostanes and naphthoquinones isolated from Antrodia salmonea and their anti-oxidative burst activity in human leukocytes. Planta Med., 72, 199-203.
  25. Don, M.J., Shen, C.C., Lin, Y.L., Syu, W.J., Ding, Y.H., and Sun, C.M. (2005) Nitrogen-containing compounds from Salvia miltiorrhiza. J. Nat. Prod., 68, 1066-1070.
  26. Syu, W.J., Shen, C.C., Lu, J.J., Lee, G.H., and Sun, C.M. (2004) Antimicrobial and  cytotoxic activities of neolignans from Magnolia officinalis. Chem. Biodivers., 1, 530-538.
  27. Yu, H.J., Sun, C.M., Chen, C.C., Wu, T.C., Wei, C.L., and Shen, C.C.* (2004) Asymmetric synthesis of panaxydol and its stereoisomers. Heterocycles, 62, 857-868.
  28. Chen, C.C., Huang, Y.L., Shiao, Y.J., Huang, R.L., Fu, T.T., and Shen, C.C.* (2003)    Synthesis of antioxidative moscatilin and its bibenzyl derivatives. Chin. Pharm. J., 55, 381-390.
  29. Shen, C.C., Kuo, Y.C., Huang, R.L., Lin, L.C., Don, M.J., Chang, T.T., and Chou, C.J. (2003)New ergostane and lanostane from Antrodia camphorata. J. Chin. Med., 14, 247-258. 8. Shen,C.C., Syu, W.J., Li, S.Y., Lin, C.H., Lee, G.H., and Sun, C.M. (2002) Antimicrobial activities of naphthazarins from Arnebia euchroma. J. Nat. Prod., 65, 1857-1862.


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