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Associate Research Fellow/Huang, Yu-Ling

黃鈺玲實驗室合照Current position: Associate Research Fellow
Telephone: (886-2) 2820-1999 Ext 6701、6691
E-mailYlhuang@nricm.edu.tw
 
Education:Ph.D., Graduated Institute of Pharmaceutical Sciences, Taipei Medical University (1999)
 
Major Professional Experiences
1. Associate Research Fellow, Division of Medicinal Chemistry, National Research Institute of Chinese Medicine (1999/08~)
2. Assistant Research Fellow, Division of Phytochemistry, National Research Institute of Chinese Medicine (1990/08~1999/07)
3. Researcher, Division of Chemistry, Brion Research institute of Taiwan 1984/10-1988/08)
 
Specialty
Phytochemistry, Spectrometric Chemistry
 
Research Description
Studying on the bioactive extracts or compounds from the natural source, especially from the medicinal plants, is one of the important ways to develop new medicines currently. We extract the traditional Chinense medicines or folk herbs and then isolate and purify the extracts by various chromatographic methods. The structures of the isolated compounds are identified through the spectroscopic analyses. Meanwhile, the isolated compounds are tested on antitumor, anti-platelet aggregation, antioxidant, antiinflammatory, vasorelaxing, and osteoporosis activities to investigate the active components. The materials we have studied include Phyllanthus species, Garcinia mangostana, Hemerocallis fulva, Helminthostachys zeylanica, Vitis thunbergii, Cissus repens, Aster species, etc.
 
Published Papers
CBI PubMed :  Yu-Ling Huang (Please click!!)
  1. Chiou, W.-F., Huang, Y.-L., & Liu, Y.-W. (2014). (+)-Vitisin A Inhibits Osteoclast Differentiation by Preventing TRAF6 Ubiquitination and TRAF6-TAK1 Formation to Suppress NFATc1 Activation. PLoS ONE, 9(2). doi:10.1371/journal.pone.0089159
  2. Huang, Y.-L., Liu, Y.-W., Huang, Y.-J., & Chiou, W.-F. (2013). A special ingredient (VtR) containing oligostilbenes isolated from Vitis thunbergii prevents bone loss in ovariectomized mice: in vitro and in vivo study. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2013/409421
  3. Lin, C.-F., Hwang, T.-L., Saleh, A. A.-S., Huang, Y.-L., Hung, Y.-Y., & Fang, J.-Y. (2013). Maximizing dermal targeting and minimizing transdermal penetration by magnolol/honokiol methoxylation. International Journal of Pharmaceutics, 445(1-2), 153-162. doi:10.1016/j.ijpharm.2013.01.049
  4. Tsai, W.-J., Yang, S.-C., Huang, Y.-L., Chen, C.-C., Chuang, K.-A., & Kuo, Y.-C. (2013). 4-Hydroxy-17-methylincisterol from Agaricus blazei Decreased Cytokine Production and Cell Proliferation in Human Peripheral Blood Mononuclear Cells via Inhibition of NF-AT and NF-B Activation. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2013/435916
  5. Wun, Z.-Y., Lin, C.-F., Huang, W.-C., Huang, Y.-L., Xu, P.-Y., Chang, W.-T., . . . Liou, C.-J. (2013). Anti-inflammatory effect of sophoraflavanone G isolated from Sophora flavescens in lipopolysaccharide-stimulated mouse macrophages. Food and Chemical Toxicology, 62, 255-261. doi:10.1016/j.fct.2013.08.072
  6. Kai, L., Shen, C.-C., Lin, C.-F., Li, S.-Y., & Huang, Y.-L. (2012). A Phenolic Derivative and Two Diacetylenes from Symphyotrichum subulatum. Planta Medica, 78(16), 1780-1783. doi:10.1055/s-0032-1315372
  7. Lee, C.-H., Huang, Y.-L., Liao, J.-F., & Chiou, W.-F. (2012). Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway. European Journal of Pharmacology, 676(1-3), 26-33. doi:10.1016/j.ejphar.2011.12.001
  8. Lin, C.-F., Chen, C.-C., Shen, C.-C., Chui, C.-H., & Huang, Y.-L. (2012). Simultaneous Determination of Resveratrol Derivatives in Vitis thunbergii Plant by High Performance Liquid Chromatography. Journal of Food and Drug Analysis, 20(2), 495-500. doi:10.6227/jfda.2012200210
  9. Lin, C.-F., Chen, Y.-J., Huang, Y.-L., Chiou, W.-F., Chiu, J.-H., & Chen, C.-C. (2012). A new auronol from Cudrania cochinchinensis. Journal of Asian Natural Products Research, 14(7), 704-707. doi:10.1080/10286020.2012.682305
  10. Lin, C.-F., Hwang, T.-L., Lin, S.-Y., & Huang, Y.-L. (2012). Bioactive Isocoumarins from Cissus pteroclada. Journal of Chinese Medicine, 23(1),41-49.
  11. Lee, C.-H., Huang, Y.-L., Liao, J.-F., & Chiou, W.-F. (2011). Ugonin K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK- and ERK-mediated expression of Runx2 and osterix. European Journal Pharmacology, 668(3), 383-389. doi:10.1016/j.ejphar.2011.06.059
  12. Ong, E.-T., Hwang, T.-L., Huang, Y.-L., Lin, C.-F., & Wu, W.-B. (2011). Vitisin B, a resveratrol tetramer, inhibits migration through inhibition of PDGF signaling and enhancement of cell adhesiveness in cultured vascular smooth muscle cells. Toxicology and Applied Pharmacology, 256(2), 198-208. doi:10.1016/j.taap.2011.08.013
  13. Y. C. Lo, Y. H. Chang, B. L. Wei, Y. L. Huang*, W. F. Chiou*, 2010, Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and β-catenin signals. J. Agric. Food Chem., 58, 6643-6649.
  14. W. F. Chiou, C. C. Shen, C. C. Chen, C. H. Lin, Y. L. Huang*, 2009, Oligostilbenes from the roots of Vitis thunbergii. Planta Med., 75, 856-859.
  15. Y. L. Huang, S. H. Loke, C. C. Hsu, W. F. Chiou*, 2008, (+)-Vitisin A inhibits RANTES production by influenza A virus-infected A549 alveolar epithelial cells. Planta Med., 74, 152-162.
  16. W. L. Kuo, C. C. Chen, P. H. Chang, L. Y. Cheng, B. J. Shien*, Y. L. Huang*, 2007, Flavonoids from Guizotia abyssinica. J. Chin. Med., 18, 121-128.
  17. C. F. Lin, C. C. Shen, C. C. Chen, S. J. Sheu*, Y. L. Huang*, 2007, Phenolic derivatives from Aster indicus. Phytochemistry, 68, 2450-2454.
 

 
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