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黃鈺玲(Huang, Yu-Ling)

黃鈺玲實驗室合照姓名: 黃鈺玲(Huang, Yu-Ling) 
職稱: 副研究員 
電話: 2820-19996701,6691
E-mail : Ylhuang@nricm.edu.tw

學歷:
台北醫學大學藥學研究所 博士

主要經歷:
國立中國醫藥研究所 副研究員 
國立中國醫藥研究所 助理研究員 
臺灣必安研究所 研究人員 

專長:
中草藥活性成分研究,植物化學,有機光譜學

研究簡介:
      對於藥物的研發,除了人工合成方式之研究外,自天然物中找尋具藥理活性之粗抽取物或活性成分,進而開發成臨床用藥,亦是受重視的研究途徑之一。本實驗室幾年來從事中草藥的化學成分研究,利用各種色層分析法對傳統中藥或常用民間草藥進行抽取、分離、純化、與構造鑑定,所得成分再與藥理研究部門的同仁合作進行活性試驗。本實驗室所探討過的藥材包括油柑屬植物、山竺果殼、金針、巴西蘑菇、苦石蓮、倒地蜈蚣、茶匙黃、葡萄科植物、馬蘭、白朮、掃帚菊、毛將軍等傳統中藥或常用民間草藥,並得到多個新化合與具抗腫瘤、抗B-型肝炎病毒、抗血小板凝集、免疫抑制、抗氧化、血管舒張與骨質疏鬆等作用的活性成分。

期刊論文:

      NCBI PubMed :  Yu-Ling Huang (Please click!!)

  1. Chiou, W.-F., Huang, Y.-L., & Liu, Y.-W. (2014). (+)-Vitisin A Inhibits Osteoclast Differentiation by Preventing TRAF6 Ubiquitination and TRAF6-TAK1 Formation to Suppress NFATc1 Activation. PLoS ONE, 9(2). doi:10.1371/journal.pone.0089159
  2. Huang, Y.-L., Liu, Y.-W., Huang, Y.-J., & Chiou, W.-F. (2013). A special ingredient (VtR) containing oligostilbenes isolated from Vitis thunbergii prevents bone loss in ovariectomized mice: in vitro and in vivo study. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2013/409421
  3. Lin, C.-F., Hwang, T.-L., Saleh, A. A.-S., Huang, Y.-L., Hung, Y.-Y., & Fang, J.-Y. (2013). Maximizing dermal targeting and minimizing transdermal penetration by magnolol/honokiol methoxylation. International Journal of Pharmaceutics, 445(1-2), 153-162. doi:10.1016/j.ijpharm.2013.01.049
  4. Tsai, W.-J., Yang, S.-C., Huang, Y.-L., Chen, C.-C., Chuang, K.-A., & Kuo, Y.-C. (2013). 4-Hydroxy-17-methylincisterol from Agaricus blazei Decreased Cytokine Production and Cell Proliferation in Human Peripheral Blood Mononuclear Cells via Inhibition of NF-AT and NF-B Activation. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2013/435916
  5. Wun, Z.-Y., Lin, C.-F., Huang, W.-C., Huang, Y.-L., Xu, P.-Y., Chang, W.-T., . . . Liou, C.-J. (2013). Anti-inflammatory effect of sophoraflavanone G isolated from Sophora flavescens in lipopolysaccharide-stimulated mouse macrophages. Food and Chemical Toxicology, 62, 255-261. doi:10.1016/j.fct.2013.08.072
  6. Kai, L., Shen, C.-C., Lin, C.-F., Li, S.-Y., & Huang, Y.-L. (2012). A Phenolic Derivative and Two Diacetylenes from Symphyotrichum subulatum. Planta Medica, 78(16), 1780-1783. doi:10.1055/s-0032-1315372
  7. Lee, C.-H., Huang, Y.-L., Liao, J.-F., & Chiou, W.-F. (2012). Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway. European Journal of Pharmacology, 676(1-3), 26-33. doi:10.1016/j.ejphar.2011.12.001
  8. Lin, C.-F., Chen, C.-C., Shen, C.-C., Chui, C.-H., & Huang, Y.-L. (2012). Simultaneous Determination of Resveratrol Derivatives in Vitis thunbergii Plant by High Performance Liquid Chromatography. Journal of Food and Drug Analysis, 20(2), 495-500. doi:10.6227/jfda.2012200210
  9. Lin, C.-F., Chen, Y.-J., Huang, Y.-L., Chiou, W.-F., Chiu, J.-H., & Chen, C.-C. (2012). A new auronol from Cudrania cochinchinensis. Journal of Asian Natural Products Research, 14(7), 704-707. doi:10.1080/10286020.2012.682305
  10. Lin, C.-F., Hwang, T.-L., Lin, S.-Y., & Huang, Y.-L. (2012). Bioactive Isocoumarins from Cissus pteroclada. Journal of Chinese Medicine, 23(1),41-49.
  11. Lee, C.-H., Huang, Y.-L., Liao, J.-F., & Chiou, W.-F. (2011). Ugonin K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK- and ERK-mediated expression of Runx2 and osterix. European Journal Pharmacology, 668(3), 383-389. doi:10.1016/j.ejphar.2011.06.059
  12. Ong, E.-T., Hwang, T.-L., Huang, Y.-L., Lin, C.-F., & Wu, W.-B. (2011). Vitisin B, a resveratrol tetramer, inhibits migration through inhibition of PDGF signaling and enhancement of cell adhesiveness in cultured vascular smooth muscle cells. Toxicology and Applied Pharmacology, 256(2), 198-208. doi:10.1016/j.taap.2011.08.013
  13. Y. C. Lo, Y. H. Chang, B. L. Wei, Y. L. Huang*, W. F. Chiou*, 2010, Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and β-catenin signals. J. Agric. Food Chem., 58, 6643-6649.
  14. W. F. Chiou, C. C. Shen, C. C. Chen, C. H. Lin, Y. L. Huang*, 2009, Oligostilbenes from the roots of Vitis thunbergii. Planta Med., 75, 856-859.
  15. Y. L. Huang, S. H. Loke, C. C. Hsu, W. F. Chiou*, 2008, (+)-Vitisin A inhibits RANTES production by influenza A virus-infected A549 alveolar epithelial cells. Planta Med., 74, 152-162.
  16. W. L. Kuo, C. C. Chen, P. H. Chang, L. Y. Cheng, B. J. Shien*, Y. L. Huang*, 2007, Flavonoids from Guizotia abyssinica. J. Chin. Med., 18, 121-128.
  17. C. F. Lin, C. C. Shen, C. C. Chen, S. J. Sheu*, Y. L. Huang*, 2007, Phenolic derivatives from Aster indicus. Phytochemistry, 68, 2450-2454.
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