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盧美光(Lu, Mei-Kuang)

盧美光個人照姓名:盧美光(Lu, Mei-Kuang) 
職稱:研究員
電話:2820-1999轉7391、7531
E-mail : mklu@nricm.edu.tw

學歷:
美國內布拉斯加州立大學 生命科學院 博士

經歷:
中研院分子生物研究所,博士後研究員
國立中國醫藥研究所 副研究員

專長:
植物生物學、真菌生物學、醣生物學、植物遺傳學

研究簡介:
藥用真菌多醣体在醫藥領域的利用,近來有廣泛的報導。如:抗腫瘤、抗發炎、抗癌、抗肝炎、抗血小板凝集。此計劃的目的,在探討如何從培養、萃取、化學及生物活性之品質管制下,生產及純化有生物活性的藥用真菌多醣体。藉由培養條件的微調、控制、多醣体的指紋圖譜及純化、生物活性指標,提升有效多醣体的產量。本研究室將針對藥用真菌,進行大量培養,純化多醣体,及生物活性機轉之探討。選擇液態培養,有利於產業的大量生產。本研究的主要目標是尋找大量生產優質真菌多醣体的條件。我們深信建立一個有品質管制的真菌多醣体生產平台,包括培養、純化、化學
分析及生物活性探討,是必要的。而真菌多醣体之研究,對未來發展抑制血管新生的藥物,及動脈週狀硬化治療之研究,將提供更多的基礎學理與應用。

期刊論文:

      NCBI PubMed :  Mei-Kuang Lu (Please click!!)

  1. Meng-Hsin Lee, Wei-Bin Lu, Mei-Kuang Lu *, Fi-John Chang * (2022) A hybrid of response surface methodology and artificial neural network in optimization of culture conditions of mycelia growth of Antrodia cinnamomea. Biomass and Bioenergy 158, 106349.  
  2. Mei-Kuang Lu*, Chi-Hsein Chao, Yu-Chi Hsu (2021) Effect of carbohydrate-feeding strategy on the production, physiochemical changes, anti-inflammation activities of polysaccharides of Poria cocos International Journal of Biological Macromolecules 192, 435-443.
  3. Mei-Kuang Lu, Chi-Hsein Chao, Yu-Chi Hsu, Chia-Chuan Chang * (2021) Structural sequencing and anti-inflammatory, anti-lung cancer activities of 1,4-α/β-sulfomalonoglucan in Antrodia cinnamomea. International Journal of Biological Macromolecules 170, 307-316.
  4. Tung-Yi Lin # *, Mei-Kuang Lu #, Ai-Jung Tseng, Chi-Hsein Chao (2020) Effects of sterol-type elicitors on biochemical characterization of polysaccharides from Antrodia cinnamomea. International Journal of Biological Macromolecules, 162, 1476-1483. # Equally contribute
  5. Meng-Hsin Lee, Chi-Hsein Chao, Yu-Chi Hsu, Mei-Kuang Lu * (2020) Production, characterization, and functions of sulfated polysaccharides from zinc sulfate enriched cultivation of Antrodia cinnamomeaInternational Journal of Biological Macromolecules 1591013-1021.
  6. Tung-Yi Lin §, Mei-Kuang Lu §, and Chia-Chuan Chang * (2020) Structural identification of a fucose-containing 1,3-β-mannoglucan from Poria cocos and its anti-lung cancer CL1-5 cells migration via inhibition of TGFβR-mediated signaling. International Journal of Biological Macromolecules 157, 311-318§ Equally contribute
  7. Mei-Kuang Lu *Meng-Hsin Lee , Chi-Hsein Chao, Yu-Chi Hsu (2020) Physiochemical changes and mechanisms of anti-inflammation effect of sulfated polysaccharides from ammonium sulfate feeding of Antrodia cinnamomea. International Journal of Biological Macromolecules 148, 715-721.
  8. Chun-Han Su, Mei-Kuang Lu, Ting-Jang Lu, Ming-Nan Lai, Lean-Teik Ng * (2020) A (1→6)-branched (1→4)-β-D-glucan from Grifola frondosa inhibits lipopolysaccharide-induced cytokine production in RAW264.7 macrophages by binding to TLR2 rather than Dectin-1 or CR3 receptors. Journal of Natural Products 83, 231-242.
  9. Tung-Yi Lin*, Chia-Chuan Chang, Ai-Jung Tseng, Chi-Hsein Chao, Mei-Kuang Lu* (2019) Sodium thiosulfate enhances production of polysaccharides and anticancer activities of sulfated polysaccharides in Antrodia cinnamomea.Carbohydrate Polymers, 216, 204-212.
  10. Tung-Yi Lin*, Ai-Jung Tseng, Wei-Lun Qiu, Chi-Hsein Chao, Mei-Kuang Lu * (2019) A sulfated glucan from Antrodia cinnamomea reduces Slug expression through   regulation of TGFβ/AKT/GSK3β axis in lung cancer.   Carbohydrate Polymers,  210, 175-184.
  11. Mei-Kuang Lu *, Tung-Yi Lin, Chia-Chuan Chang * (2018) Chemical identification of a sulfated glucan from Antrodia cinnamomea and its anti-cancer functions via inhibition of EGFR and mTOR activity. Carbohydrate Polymers 202, 536-544.
  12. Tung-Yi Lin*, Ai-Jung Tseng, Chi-Hsein Chao, Mei-Kuang Lu* (2018) Microelements induce changes in characterization of sulfated polysaccharides from Antrodia cinnamomea. International Journal of Biological Macromolecules 120, 952-958.
  13. Hsien-Yeh Hsu*, Tung-Yi Lin, Chun-Hao Hu, David Ta Fu Shu, Mei-Kuang Lu* (2018) Fucoidan upregulates TLR4/CHOP-mediated Caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells. Cancer Letters 432, 112-120.
  14. Jing-Jy Cheng, Chi-Hsein Chao, Mei-Kuang Lu * (2018) Large-scale preparation of sulfated polysaccharides with anti-angionenic and anti-inflammatory properties from Antrodia cinnamomia.International Journal of Biological Macromolecules 113,1198-1205.
  15. Chia-Chuan Chang *, Jing-Jy Cheng, I-Jung Lee, Mei-Kuang Lu* (2018) Purification, structural elucidation, and anti-inflammatory activity of xylosyl galactofucan from Armillaria mellea.International Journal of Biological Macromolecules 114,584-591
  16. Mei-Kuang Lu *,1, Tung-Yi Lin1, Chun-Hao Hu, Chi-Hsein Chao,  Chia-Chuan Chang *, and Hsien-Yeh Hsu * (2017) Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGFβ/FAK/Slug axis suppression. Carbohydrate Polymers 167, 229-239. *Corresponding author  1 Equally contribute
  17. Mei-Kuang Lu*, Tung-Yi Lin, Chi-Hsein Chao, Chun-Hao Hu, and Hsien-Yeh Hsu * (2017) Molecular mechanism of Antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor β receptor degradation. International Journal of Biological Macromolecules 95,1144-1152.
  18. Yun-Ting Chen, Yuh-Chiang Shen, Meng-Chi Chang, Mei-Kuang Lu * (2016) Precursor-feeding strategy on the triterpenoid production and anti-inflammatory activity of Antrodia cinnamomea. Process Biochemistry 51, 941-949.
  19. Feng-Lin Hsu, Hsiao-Chuan Chen, and Mei-Kuang Lu * (2016) Polysaccharides from Cunninghamia konishii promote the mycelial growth of Antrodia cinnamomea.Food Hydrocolloids 53, 2-6
  20. Jing-Jy Cheng, Chi-Hsein Chao, Pin-Chun Chang, Mei-Kuang Lu * (2016) Studies on anti-inflammatory activity of sulfated polysaccharides from cultivated fungi Antrodia cinnamomea. Food Hydrocolloids 53, 37-45
  21. Chang, C.-W., Lur, H.-S., Lu, M.-K., & Cheng, J.-J. (2013). Sulfated polysaccharides of Armillariella mellea and their anti-inflammatory activities via NF-κB suppression. Food Research International, 54(1), 239-245. doi:10.1016/j.foodres.2013.07.005
  22. Lee, M.-H., Chao, C.-H., & Lu, M.-K. (2012). Effect of carbohydrate-based media on the biomass; polysaccharides molecular weight distribution and sugar composition from Pycnoporus sanguineus. Biomass and Bioenergy, 47, 37-43. doi:10.1016/j.biombioe.2012.10.007
  23. Cheng, J.-J., Chang, C.-C., Chao, C.-H., & Lu, M.-K. (2012). Characterization of fungal sulfated polysaccharides and their synergistic anticancer effects with doxorubicin. Carbohydrate Polymers, 90(1), 134-139. doi:10.1016/j.carbpol.2012.05.005
  24. Kuo, C.-I., Chao, C.-H., & Lu, M.-K. (2012). Effects of auxins on the production of steroidal alkaloids in rapidly proliferating tissue and cell cultures of Solanum lyratum. Phytochemical Analysis, 23(4), 400-404. doi:10.1002/pca.1371
  25. Chao, C.-H., & Lu, M.-K. (2012). Effects of Carbon-Source on the Structural Changes of Polysaccharides in the Dietary Mushroom Agaricus subrufescens. Journal of Chinese Medicine, 23(1), 31-40.
  26. Chao, C.-H., Wu, H.-J., & Lu, M.-K. (2011). Promotion of fungal growth and underlying physiochemical changes of polysaccharides in Rigidoporus ulmarius, an edible Basidiomycete mushroom. Carbohydrate Polymers, 85(3), 609-614.  doi:10.1016/j.carbpol.2011.03.023
  27. Chang, T.-T., Chao, C.-H., & Lu, M.-K. (2011). Enhanced biomass production of Pycnoporus sanguineus and alterations in the physiochemical properties of its polysaccharides. Carbohydrate Polymers, 83(2), 796-801. doi:10.1016/j.carbpol.2010.08.055
  28. Cheng, J.-J., Lu, M.-K., Lin, C.-Y., & Chang, C.-C. (2011). Characterization and functional elucidation of a fucosylated 1,6-α-D-mannogalactan polysaccharide from Antrodia cinnamomea. Carbohydrate Polymers, 83(2), 545-553. doi:10.1016/j.carbpol.2010.08.016
  29. Men-Chi Chang, Wei-Fu Chien, Chi-Hsein Chao, Mei-Kuang Lu * (2010) Effects of cold stress on alterations of physiochemical and chemical properties of rice polysaccharides. Carbohydrate Polymers 80, 374-377.
  30. Mei-Kuang Lu1, Jing-Jy Cheng1, Cha-Yui Lin, Chia-Chuan Chang * (2010) Purification, structural elucidation, and anti-inflammatory effect of a water-soluble 1,6-branched 1,3-α-d-galactan from cultured mycelia of Poria cocos. Food Chemistry 118, 349-356. 1 Equally contribute.
  31. Jing-Jy Cheng 1, Huu-Sheng Lur1, Nai-Kuei Huang, Hsuan-Pei Chen, Cha-Yui Lin, Mei-Kuang Lu * (2009) Exploring the potential of biopharmaceutical production by Rigidoporus ulmarius: cultivation, chemistry, and bioactivity studies. Process Biochemistry 44, 1237-1244.
  32. Jing-Jy Cheng, Nai-Kuei Huang, Huu-Sheng Lur, Chung-Io Kuo, Mei-Kuang Lu * (2009) Characterization and biological functions of sulfated polysaccharides from sulfated-salt treatment of Antrodia cinnamomea. Process Biochemistry 44, 453-459.
  33. Jing-Jy Cheng, Cha-Yui Lin, Huu-Sheng Lur, Hsuan-Pei Chen, Mei-Kuang Lu * (2008) Properties and biological functions of polysaccharides and ethanolic extracts isolated from medicinal fungus, Fomitopsis pinicola. Process Biochemistry 43, 829-834.
  34. Mei-Kuang Lu, Jing-Jy Cheng, Wen-Lin Lai, Yen-Ru Lin, Nai-Kuei Huang (2008) Fermented Antrodia cinnamomea extract prevents rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family. Journal of Agricultural Food Chemistry 56, 865-874.
  35. Meng-Hsin Lee, Jing-Jy Cheng, Cha-Yui Lin, Yi-Jyun Chen, Mei-Kuang Lu * (2007) Precursor feeding strategy for the production of solanine, solanidine and solasodine by a cell culture of Solanum lyratum. Process Biochemistry 42, 899-903.
  36. Feng-Lin Hsu, Cheng-Jen Chou, Yi-Chieh Chang, Tun-Tschu Chang, Mei-Kuang Lu * (2006) Promotion of hyphal growth and underlying chemical changes in Antrodia cinnamomea by host factors from Cinnamomum cinnamomea. International Journal of Food Microbiology 106, 32-38.
  37. Mei-Kuang Lu, Jing-Jy Cheng, Wen-Lin Lai, Yen-Ru, Lin, and Nai-Kuei Huang (2006) Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of Adenosine A2A receptors. Life Sciences 79, 252-258.
  38. Shih Chung Chen1, Mei-Kuang Lu1, Jing-Jy Cheng , Danny Ling Wang (2005) Antiangiogenic activities of polysaccharides isolated from medicinal fungi. FEMS Microbiology Letters 249, 247-254. 1Equally contribute.
  39. Jing-Jy Cheng, Chao-Jan Yang, Chia-Hua Cheng, Ya-Ting Wang, Nai-Kuei Huang, Mei-Kuang Lu * (2005) Characterization and functional study of Antrodia camphorata lipopolysaccharide. Journal of Agricultural Food Chemistry 56, 865-874.
  40. Jing-Jy Cheng, Nai-Kuei Huang, Tun-Tschu Chang, Danny Ling Wang, Mei-Kuang Lu * (2005) Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells. Life Sciences 76, 3029-3042.
  41. Nai-Kuei Huang, Jing-Jy Cheng, Wen-Lin Lai, Mei-Kuang Lu * (2005) Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis. FEMS Microbiol.ogy Letters 244, 213-219.
  42. Yuh-Chiang Shen, Cheng-Jen Chou, Yea-Hwey Wang, Chieh-Fu Chen, Yueh-Chinh Chou, Mei-Kuang Lu * (2004) Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fraction from five different Cinnamomum genera. FEMS Microbiology Letters 231, 137-143.
  43. Guei-Jane Wang , Hsiang-Wen Tseng , Cheng-Jen Chou , Tung-Hu Tsai , Chi-Tin Chen , Mei-Kuang Lu * (2003) The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca2+-NO-cGMP pathway. Life Sciences 73, 2769-2783.
  44. I-Hung Lee, Ray-Ling Huang, Chi-Ting Chen,Hsiao-Chuan Chen, Wen-Chi Hsu, Mei-Kuang Lu * (2002) Antrodia camphorata polysaccharide exhibits anti-hepatitis B virus effects. FEMS Microbiology Letters 209, 63-67.


*Corresponding author*

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