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黃乃瑰(Huang, Nai-Kuei)

Huang, Nai-KueiCurrent position: Research Fellow
E-mail: andrew@nricm.edu.tw


Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center


Major Professional Experiences
Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica


Neuroscience, Signal Transduction, Drug Abuse


Research Description
The goal of my laboratory is to screen the effective component(s) from Chinese herbal medicine and to study their mechanisms in treating neurodegenerations. Chinese herbal medicines could not only regard as our culture properties but also play important roles in traditional or alternative medicines. Currently, the explorations of new drugs from Chinese herbal medicines are potentially important to the clinical medicines, basic researches, biotechnology industries. On the other hand, the incidence of neurodegenerations, such as Parkinson’s disease, Huntington’s disease, and abusive drug-induced neurotoxicity, are increasing recently, however the proper therapeutic ways are lack. Therefore, I have set different models to screen effective component(s) from Chinese herbal medicines to treat neurodegeneration. These models include Parkinson’s disease, Huntington’s disease, ischemia, and abusive drug-induced neurotoxicity.


Published Papers
NCBI PubMed :  Nai-Kuei Huang (Please click!!)
  1. Ji, H.-X., Chang, W.-S., Tsai, C.-W., Wang, J.-Y., Huang, N.-K., Lee, A.-S., . . . Bau, D. A. T. (2015). Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotype to Gastric Cancer Risk in Taiwan. Anticancer Research, 35(9), 4975-4981.
  2. Huang, C.-L., Lee, Y.-C., Yang, Y.-C., Kuo, T.-Y., & Huang, N.-K. (2012). Minocycline prevents paraquat-induced cell death through attenuating endoplasmic reticulum stress and mitochondrial dysfunction. Toxicology Letters, 209(3), 203-210. doi:10.1016/j.toxlet.2011.12.021
  3. Kuo, T.-Y., Huang, C.-L., Yang, J.-M., Huang, W.-J., Huang, N.-K., Chen, Y.-W., . . . Yang, Y.-C. (2012). The role of ribosylated-BSA in regulating PC12 cell viability. Cell Biology and Toxicology, 28(4), 255-267. doi:10.1007/s10565-012-9220-3
  4. Lee, Y.-C., Yang, Y.-C., Huang, C.-L., Kuo, T.-Y., Lin, J.-H., Yang, D.-M., & Huang, N.-K. (2012). When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders? PLoS One, 7(6). doi:10.1371/journal.pone.0038865
  5. Chen, J.-B., Liu, E. M., Chern, T.-R., Yang, C.-W., Lin, C.-I., Huang, N.-K., . . . Fang, J.-M. (2011). Design and synthesis of novel dual-action compounds targeting the adenosine A2A receptor and adenosine transporter for neuroprotection. ChemMedChem, 6(8), 1390-1400. doi:10.1002/cmdc.201100126
  6. Huang, C.-L., Yang, J.-M., Wang, K.-C., Lee, Y.-C., Lin, Y.-L., Yang, Y.-C., & Huang, N.-K. (2011). Gastrodia elata prevents huntingtin aggregations through activation of the adenosine A2A receptor and ubiquitin proteasome system. Journal of Ethnopharmacology, 138(1), 162-168. doi:10.1016/j.jep.2011.08.075
  7. Huang, N.-K., Lin, J.-H., Lin, J.-T., Lin, C.-I., Liu, E. M., Lin, C.-J., . . . Chern, Y. (2011). A new drug design targeting the adenosinergic system for Huntington's disease. PLoS One, 6(6). doi:10.1371/journal.pone.0020934
  8. Pao, P. C., Huang, N. K., Liu, Y. W., Yeh, S. H., Lin, S. T., Hsieh, C. P., . . . Lee, Y. C. (2011). A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells. Cell Death & Differentiation, 18, 1791-1804. doi:10.1038/cdd.2011.52
  9. Tsai, C.-F., Huang, C.-L., Lin, Y.-L., Lee, Y.-C., Yang, Y.-C., & Huang, N.-K. (2011). The neuroprotective effects of an extract of Gastrodia elata. Journal of Ethnopharmacology, 138(1), 119-125. doi:10.1016/j.jep.2011.08.064
  10. Chin, L.T., Huang, P.R., Hu, K.Y., Huang, N.K., Chiu, C.D., Hour, A.L., Shui, H.A., Chu, C.H., Chen, H.M. (2010) Proteomics-based translational approach reveals an antifolate resistance inherent in human plasma derived from blood donation. J. Proteome Res., 9:3091–3102.
  11. Chen, T.K., Huang, C.L., Lee, Y.C., Liao, W.C., Huang, N.K.* (2010) The roles of the thioredoxin system and peroxiredoxins in 1-methyl-4-phenyl-pyridinium ion-induced cytotoxicity in rat pheochromocytoma cells. Toxicol. In Vitro, 24:1577–1583.
  12. Chen, P., Jou, Y.S., Fann, C.S., Chen, J.W., Chung, C.M., Lin, C.Y., Wu, S.Y., Kang, M.J., Chen, Y.C., Jong, Y.S., Lo, H.M., Kang, C.S., Chen, C.C., Chang, H.C., Huang, N.K., Wu, Y.L., and Pan, W.H. (2009) Lipoprotein lipase variants associated with an endophenotype of hypertension: hypertension combined with elevated triglycerides. Hum. Mutat., 30, 49-55.
  13. Lin, Y.L., Wang, G.J., Huang, C.L., Lee, Y.C., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2009) Ligusticum chuanxiong as a potential neuroprotectant for preventing serum deprivation-induced apoptosis in rat pheochromocytoma cells: functional roles of mitogen-activated protein kinases. J. Ethnopharmacol., 122, 417-423.
  14. Lin, Y.L., Huang, C.L., Lee, Y.C., Liao, W.C., Lai, W.L., Lin, Y.J., and Huang, N.K.* (2009) Mechanisms of Panax ginseng in preventing rat pheochromocytoma cells from apoptosis. J. Ethnopharmacol., 125, 10-15.
  15. Chern, Y., Lin, Y.L., and Huang, N.K. (2008/04) Therapeutic Gastrodia extracts (US 3272869).
  16. Lu, M.K., Cheng, J.J., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2008) Fermented Antrodia cinnamomea extract prevents rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family. J. Agri. Food Chem., 56, 865-874.
  17. Lin, Y.L., Lee, Y.C., Huang, C.L., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2007) Ligusticum chuanxiong prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis through a protein kinase A-dependent pathway. J. Ethnopharmacol., 109, 428-434.
  18. Huang, C.L., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2007) Methamphetamine downregulates the expressions of peroxiredoxins in rat pheochromocytoma cells. Biochem. Biophys. Res. Commun., 354,96-101.
  19. Huang, N.K., Chern, Y., Fang, J.M., Lin, C.I., Chen, W.P., and Lin, Y.L. (2007) Neuroprotective principles from Gastrodia elata. J. Nat. Prod., 70, 571-574.
  20. Lu, M.K., Cheng, J.J., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2006) Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A2A receptors. Life Sci., 79, 252-258.
  21. Huang, N.K., Cheng, J.J., Lai, W.L., and Lu, M.K. (2005) Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis. FEMS Microbiol. Lett., 244, 213-219.


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