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Research Specialty

FROM NRICM SITE
Research Fellow
Special Professional Service
Assay
1. Parkinson's disease
2. Sipinocerebellar ataxia type 2 and 3 diseases
3. Huntington's disease
4. Ischemia
5. Substance abuse-induced neurotoxicity
1. cytotoxicity assay, behavioral performance
2. cytotoxicity assay, behavioral performance
3. cytotoxicity assay, behavioral performance
4. cytotoxicity assay
5. cytotoxicity assay, behavioral performance
1.Cancer
2.Trauma
3.Cardiovascular Disease
1. Cancer cell cytotoxicity (SRB assay) & angiogenesis assay (Matrigel tube formation assay)
2. Matrigel tube formation assay & Migration assay
3. ATF3 promotor screen
Shiao, Young-Ji
1.Alzheimer's disease
2.Parkinson's disease
3.Epilepsy
1.Neurontoxicity in primary rat cortical neuron culture
2.Activation of primary rat cortical glial cell culture
3.Drug activity evaluation in APP/PS1 transgenic mice
1. Diabetes and related complications
2. Metabolic syndrome
3. Comorbidity of diabetes and Alzheimer's disease
1a. Multiple assays for measuring hypoglycemic activity.
1b. Glucose  tolerance test; HOMA values, HbA1c%
2.  Energy expediture and endorine hormome assays. Gut microbiome analysis.
3. Blood Biochemistry.
1.Ischemic Stroke & Neurodegeneration
2.Osteoarthritis
3.Neurogenesis Promotion
1.Middle cerebral artery occlusion & OGD cellular model
2.MIA-induced cartilage lesions
3.Stem cells in SVZ&DGZ
Chiou, Wen-Fei
1. Ovariectomy-induced osteoporosis
2. Osteoarthritis-induced osteoporosis
3. Joint inflammation
1. In vitro: (1) Osteoblast differentiation assay (ALP
activity, mineralization, osteoids measurement,
action mechanism); (2) Osteoclast differentiation assay (TRAP activity, bone resorption, MNC formation, actin polymerization, action mechanism); (3) Chondrocyte differentiation (Alcian blue assay); (4) macrophage activation (pro-inflammatory cytokines measurement)
2. In vivo: (1) bone mineral density, (2) trabecular microarchitecture 3D measurement, (3) histochemistry assay, (4) bone turn-over rate; (5) paw edema measurement
1. Cancer and cancer side effects
2. Infectious diseases (Japanese encephalitis, dengue fever, hepatitis C)
1. Antiproliferation assay (SRB, MTT)
2. Tumor xenograft mouse model
3. Cancer-related fatigue mouse model
4. Hepatitis C virus replicon cell model
5. Virus culture and titer determination (Japanese encephalitis virus, dengue virus)
1.Immuno-Oncology
2.Alzheimer's disease
1. TCM antibody、Phage Display
2. BACE1 Inhibition (ELISA)
3. Drug design, peptide design, antibody design and small compound design
1. Cardiovascular diseases
1. Anti-platelet aggregation analysis
Wei, Wen-Chi
1. Breast cancer
2. Inflammatory bowel disease, IBD
3. Colon cancer and melanoma
1. Cytokine production assay
2. Differentiation and functional assays for MDSCs and T cells
3. Assays for protein expression and signal transduction
4. CRISPR/Cas gene editing
5. Orthotopic and tumor-resection mouse mammary tumor models
6. Dextran sulfate sodium (DSS)-induced mouse colitis model
Research Fellow
Safety Model
Assay
Ueng, Yune-Fang
1.Alterations of drug metabolism;
2.Genotoxicity
1.Human cytochrome P450 activities;
2.Metabolic activities of mouse and rat liver microsomes and cytosols;
3.Genotoxicity
　
Research Fellow
 　
Special Professional Service
 　 　
Assay
 　
1.Botany
2.Biology resources
3.Herbarium management
1.Morphological, Microscopy Identification, DNA Identification
2.Fieldwork, Resource Exploration, Scientific Investigation
3.Herbarium Specimens Production and Collect
1. Studies on the bioactive constituents and quality analysis of herbal medicine
2. The development of herbal medicine for the curing cancer and metabolic sydrome
1. The isolation of bioactive constituents
2. Qualitative and quantitative analysis of quality control
3. Spectroscopic analysis for the elucidation of chemical structures
4. The screening platform of anticancer
1. Glycobiology
2.Mass-produce of high quality medicinal plants and fungi with the integration of culturing system, chemical profiling and bio-active guided selection.
1.Gel-filtration column chromatograohy, Size exclusion column chramatography
2. HPAEC
3. Fermentation
4. Plant tissue and cell culture
1.Oganic synthesis
2.Isolation and structure elucidation
3.Quality analysis of traditional Chinese medicine
1.Total synthesis, Synthesis of analogues
2.Column chromatography, Spectral analysis (NMR, MS etc.)
3.HPLC, UPLC, GC/MS, LC/MS/MS, LC/HRMS
1. Studies on the bioactive constituents of medicinal plants 2. Quality analysis of traditional Chinese medicine
1.Column chromatography, Spectral analysis (NMR, MS etc.)
2.HPLC, UPLC, GC/MS, LC/MS/MS, LC/HRMS
1.Oganic synthesis
2.Isolation and structure elucidation
3.Quality analysis of traditional Chinese medicine
1.Total synthesis, Synthesis of analogues
2.Column chromatography, Spectral analysis (NMR, MS etc.)
3.HPLC, UPLC, GC/MS, LC/MS/MS, LC/HRMS
1. Natural productions isolation and elucidation
2. Quality control of botany drugs
3. cultural techniques of marine microbes and algae
1.Column chromatography, Spectral analysis (NMR, MS etc.)
2.HPLC, UPLC, GC/MS, LC/MS/MS, LC/HRMS
3. Fermentation and photo-bioreactor
1. Drug design and synthesis
2. Development of active components in botanicals
3. Quality analysis of botanical materials
1.Synthesis & manufacturing of active components
2.Isolation and identification of natural compounds (column chromatographyand spectral analysis etc.)
3.HPLC, UPLC, GC/MS, LC/MS/MS, LC/HRMS
Lin, Lie-Chwen
1. Analysis and standardization of medicinal plants.
2. Studies on the bioactive ingredients of medicinal plants.
3. Research and development for the manufacturing process of target compounds.
1.Sample preparation techniques.
2.Column separation techniques.
3.Qualitative and quantitative analysis.
4.Spectral Analysis.
5.Chemical structure elucidation.
Chen, Chang-Chang
1. Germplasm preservation and cultivation of Chinese materia medica.
2. Educational Herb Garden management.
1.Tissue culture.
2.Cropping system.
Sunny Jui-Shan, Lin
1.Chinese Medical Physiology
2.Chinese Medical Pathology
3.Research of Chinese Medical Body Constitution
4.Clinical Trials of Integration of Chinese and Western Medicine
Clinical research and clinical trials