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Director

FROM NRICM SITE
所長玉照Prof. Dr. Dr. h.c. mult. Fang-Rong Chang
Tel: 02-2820-1999 ext 3101
 
Current Position
Director, National Research Institute of Chinese Medicine (NRICM), Ministry of Health and Welfare(2018/Feb.~)
Professor, Lab of Pharmacognosy,Graduate Institute of Natural Products,College of Pharmacy, Kaohsiung Medical University (KMU) (2005/Aug.~)
Adjunct Professor, Department of Marine Biotechnology and Resources, National Sun Yat-sen University (NSYSU) (2009/Aug.~)
 
Education
Szeged University (Hungary), Doctor Honoris Causa in Pharmacy, 2018
Uppsala University (Sweden), Honorary Doctor in Pharmacy, 2018
Okayama University of Science (Japan), Transgenic Plant Assay, Post Dr. Scholar, 2004
University of North Carolina at Chapel Hill (USA), Natural Products & Medicinal Chemistry, Post Dr. Scholar, 1998 & 2001
Kaohsiung Medical University (Taiwan), Pharmacognosy, Master &Ph. D., 1990-1995
Chung-Shan Medical University, Nutrition, Bachelor, 1984-1988
 
Experiences
Director, National Research Institute of Chinese Medicine (NRICM), Ministry of Health and Welfare (2018/02-now)
Professor, Lab of Pharmacognosy and Graduate Institute of Natural Products, KMU (2005/08-now)
Adjunct Professor, Department of Marine Biotechnology and Resources, NSYSU (2009/08-now)
Vice Dean, Office of Global Affairs, KMU (2013/08-2018/01)
Head, Division of Graduate Academic Affairs, KMU (2012/08-2013/07)
Director, Graduate Institute of Natural Products, KMU (2006/08-2012/07)
Visiting Scholar, Okayama University of Science, Tokushima Bunri University, Chiba University of Science (2007/12)
R&D leader, College of Pharmacy, KMU (2005/08-2006/07)
Associate Professor, Pharmacognosy and GINP, KMU (2002/08-2005/07)
Assistant Professor, Pharmacognosy and GINP, KMU (1998/08-2002/07)
Teaching Assistant and Instructor, Pharmacognosy Lab, Faculty of Pharmacy, KMU (1994/05-1998/07)
 
Specialty
Natural Products Chemistry, Medicinal Chemistry, Production Modulation on Microbial Secondary Metabolites, Functional Food, Traditional Chinese (Herbal) Medicine, and New Drug Development 
 
Awards and Honors
1995    Second Grade Award, National Science Council, Taiwan
1997, 1998, 2000 First Grade Award, National Science Council, Taiwan
1998    Outstanding Academic Alumnus, Chung-Shan Medical University, Taiwan
2004    Best Young Researcher Award, KMU, Taiwan 
2005~2009 CGCM, Consortium for Globalization of Chinese Medicine, Invited Panel Member
2006    Incubation Project Award of Excellent Researchers,National Science Council, Taiwan
2011    The First Award, Natural Science, Taiwan Tech Trek（Migrant Bird）Program, Taiwan
2012    Faculty Gold Medal, Faculty of Pharmacy, University of Szeged, Hungary
2012    The First Award, National Innovation Award-New Drug Development for Anti-Diabetes Agents, Taiwan 
2015    Outstanding Academic Alumnus, National Feng-Shan Senior High School, Taiwan
2015    National Innovation Award, Institute for Biotechnology and Medicine Industry & Research Center for Biotechnology and Medicine Policy, Taiwan.
2017    Outstanding Academic Alumnus, Pharmacy Education Foundation, College of Pharmacy, KMU
2018    Honorary Doctor in Pharmacy, Uppsala University, Sweden
2001~  Project Award, National Science Council, Taiwan
2006~  The organizer of the Global Pharmacy courses of KMU and Uppsala University. 
2009~  OutstandingResearch Award, Kaohsiung Medical University 
2009~  Outstanding Industrial-Academic Cooperation Award, Kaohsiung Medical University 
2010~  Special Researcher Award, National Science Council (Ministry of Science and Technology)
2010~  The advisory board, Office for Operation of Industry-University Cooperation, Kaohsiung Medical University 
2012~  Committee Member, Pingtung Agricultural Biotechnology Park (PABP), Taiwan 
2012~  Teaching Award, Kaohsiung Medical University
 
Patent and IP right transfer
Over 20 patents and technique transfer cooperation 
 
Publications
Over 320 paper published since 1991, Editorial Board Member of 8 international peer-reviewed journals
Publication List of 2016 and 2017 (39 papers)：
  1. Chih-Chuang Liaw, Jing-Ru Liou, Tung-Ying Wu, Fang-Rong Chang, and Yang-Chang Wu, 2016. “Acetogenins from Annonaceae.” Prog. Chem. Org. Nat. Prod., 101, 113−230. (SCI)Chih-Chuang Liaw, Jing-Ru Liou, Tung-Ying Wu, Fang-Rong Chang, and Yang-Chang Wu, 2016. “Acetogenins from Annonaceae.” Prog. Chem. Org. Nat. Prod., 101, 113−230. (SCI)
  2. Ching-Chia Li*, Juan-Cheng Yang*, Mei-Chin Lu, Chia-Lin Lee, Chieh-Yu Peng, Wei-Yu Hsu, Yun-Hao Dai, Fang-Rong Chang, Da-Yong Zhang, Wen-Jeng Wu, and Yang-Chang Wu, 2016, “ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer.” Oncotarget, 7, 1947−1959. (SCI)
  3. Amos C. Hung, Chun-Hao Tsai, Ming-Feng Hou, Wen-Lin Chang, Chie-Hong Wang, Yi-Chen Lee, Alice Ko, Stephen Chu-Sung Hu, Fang-Rong Chang, Pei-Wen Hsieh*, and Shyng-Shiou F. Yuan*, 2016. “The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway.” Cancer Lett., 371, 251–261. (SCI)
  4. Yu-Ming Hsu, Tung-Ying Wu, Ying-Chi Du, Mohamed El-Shazly, LudgerBeerhues, Tran Dinh Thang, Hoang Van Luu, Tsong-Long Hwang, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “3-Methyl-4,5-dihydrooxepine, polyoxygenatedseco-cyclohexenes and cyclohexenes from Uvariaflexuosa and their anti-inflammatory activity.” Phytochemistry, 122, 184–192. (SCI)
  5. I-Wen Lo, Yuan-Bin Cheng, Yi-Jin Hsieh, Tsong-Long Hwang, Deng-En Shieh, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “Chemical Constituents and LC-profile of Fresh Formosan Lonicera japonica Flower Buds.” Nat. Prod. Commun., 11, 1–4. (SCI)
  6. I-Wen Lo, Yuan-Bin Cheng, Chen-Chang Haung, Tsong-Long Hwang, Chin-Chung Wu, Jing-Ru Liou,Ming-Feng Hou, Shyng-Shiou Yuan, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “Constituents of the Leaves of Pandanus utilis.” Nat. Prod. Commun., 11, 173–176. (SCI)
  7. Ching-Peng Chiu, Shan-Chi Liu, Chih-Hsin Tang, You Chan, Mohamed El-Shazly, Chia-Lin Lee, Ying-Chi Du, Tung-Ying Wu, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “Anti-inflammatory Cerebrosides from Cultivated Cordycepsmilitaris.” J. Agric. Food Chem., 64, 1540−1548. (SCI)
  8. Sándor B. Ötvös, Chi-Ting Hsieh, Yang-Chang Wu, Jih-Heng Li, Fang-Rong Chang*, and Ferenc Fülöp*, 2016. “Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core.” Molecules, 21, 318. (SCI)
  9. Mohamed El-Shazly, Chi-Jung Tai, Tung-Ying Wu, DezsőCsupor, Judit Hohmann, Fang-Rong Chang*, and Yang-Chang Wu*, 2016. “Use, history, and liquid chromatography/mass spectrometry chemical analysis of Aconitum.” J. Food Drug Anal., 24, 29−45. (SCI)
  10. Michal Korinek, Vitthal D. Wagh, I-Wen Lo, Yu-Ming Hsu, Hsue-Yin Hsu, Tsong-Long Hwang, Yang-Chang Wu, Yuan-Bin Cheng, Bing-Hung Chen*, and Fang-Rong Chang*, 2016. “Antiallergicphorbol esters from the seeds of Aquilariamalaccensis.” Int. J. Mol. Sci., 17, 398. (SCI)
  11. Yuan-Bin Cheng, Jin-Ching Lee, I-Wen Lo, Shu-Rong Chen, Hao-Chun Hu, Yu-Hsuan Wu, Yang-Chang Wu*, and Fang-Rong Chang*, 2016. “Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2.” Bioorg. Med. Chem. Lett., 26, 2344−2348. (SCI)
  12. Naglaa S. Ashmawy, Mohamed L. Ashour, Michael Wink, Mohamed El-Shazly, Fang-Rong Chang, NohaSwilam, Ashraf B. Abdel-Naim, NahlaAyoub*, 2016.“Polyphenols from Erythrina crista-galli: Structures, Molecular Docking and Phytoestrogenic Activity.” Molecules, 21, 726. (SCI)
  13. Chi-ChenYeh, Kun-TzuLi, Jen-Yang Tang, Hui-RuWang, Jing-RuLiu, Hurng-Wern Huang, Fang-RongChang, Cheng-EnTsai, I-WenLo, Ming-YiiHuang, and Hsueh-WeiChang*, 2016. “Butanol-partitioned extraction from aqueous extract of gracilariatenuistipitata inhibits cell proliferation of oral cancer cells involving apoptosis and oxidative stress.”DNA Cell Biol., 35(5), 210-216. (SCI)
  14. Yu-Ting Tseng, Cheng-Sheng Chenc, Yuh-JyhJongd, Fang-Rong Chang, Yi-Ching Lo*, 2016. “Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy.”Pharmacol Res., 111, 58-75. (SCI)
  15. Jia-Fu Li, Hua Fang, Xia Yan, Fang-Rong Chang, Zhen Wu, Yun-Long Wu*,Ying-Kun Qiu*, 2016. “On-line comprehensive two-dimensional normal-phase liquid chromatography-reversed-phase liquid chromatography for preparative isolation of toad venom.”J Chromatogr A., 1456, 169-75.(SCI)
  16. OrsolyaRoza, Ana Martins, Judit Hohmann, Wan-Chun Lai, Jacobus Eloff, Fang-Rong Chang, DezsőCsupor*, 2016. “Flavonoids from cyclopiagenistoides and their xanthine oxidase inhibitory activity.”Planta Med., 82(14), 1274-8. (SCI)
  17. Xia Yana, Li-Juan Wang, Zhen Wu, Yun-Long Wu, Xiu-Xiu Liu,Fang-Rong Chang, Mei-Juan Fang*, Ying-Kun Qiu*,2016. “New on-line separation workflow of microbial metabolites via hyphenation of analytical and preparative comprehensive two-dimensional liquid chromatography.”J Chromatogr B., 1033-1034, 1-8. (SCI)
  18. Jin-Ching Lee, Fang-Rong Chang, Shu-Rong Chen, Yu-Hsuan Wu, Hao-Chun Hu, Yang-Chang Wu, Anders Backlund, Yuan-Bin Cheng*, 2016. “Anti-Dengue Virus Constituents from Formosan ZoanthidPalythoamutuki.”Mar. Drugs., 14(8), 151. (SCI)
  19. Fang-Rong Chang, Shih-Ting Huang, Chih-Chuang Liaw, Ming-Hong Yen, Tsong-Long Hwange, Ching-Yeu Chen, Ming-Feng Hou, Shyng-Shiou Yuan, Yuan-Bin Cheng, Yang-Chang Wu*,2016. “Diterpenes from Grangeamaderaspatana.”Phytochemistry., 131, 124-129. (SCI)
  20. Ken-ichi Nakashima, Naohito Abe, Fang-Rong Chang, Makoto Inoue, Masayoshi Oyama*,2016. “Pteleifolols A-E, acetophenone di-C-glycosides and a benzopyran dimer from the leaves of Melicopepteleifolia.”J Nat Med.DOI 10.1007/s11418-016-1035-8. (SCI)
  21. Ching-Ying Kuo, István Zupkó, Fang-Rong Chang, Attila Hunyadi, Chin-Chung Wu, Teng-Song Weng, Hui-Chun Wang*,2016. “Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway.”ToxicolApplPharmacol., 311, 99-105. (SCI)
  22. Ching-Peng Chiu, Tsong-Long Hwang, You Chan, Mohamed El-Shazly, Tung-Ying Wu, I-Wen Lo, Yu-Ming Hsu, Kuei-Hung Lai, Ming-Feng Hou, Shyng-Shiou Yuan, Fang-Rong Chang*, Yang-Chang Wu*,2016. “Research and development ofCordycepsin Taiwan.”Food Science and Human Wellness, 5, 177–185. (SCI)
  23. Michal Korineka, Kuan-Ming Chen, Yu-Han Jiang, Mohamed El-Shazly, Joel Stockerd, Chon-Kit Choua, Tsong-Long Hwang, Yang-Chang Wu, Bing-Hung Chen*, Fang-Rong Chang*,2016. “Anti-allergic potential of Typhoniumblumei: inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx.” Phytomedicine, 23 (14), 1706–1715. (SCI)
  24. Yu-Ming Hsu, Fang-Rong Chang, I-Wen Lo, Kuei-Hung Lai, Mohamed El-Shazly, Tung-Ying Wu, Ying-Chi Du,Tsong-Long Hwang,Yuan-Bin Cheng*,Yang-Chang Wu*,2016. “Zoanthamine-type alkaloids from the zoanthidZoanthuskuroshio collected in Taiwan and their effects on inflammation.”J Nat Prod., 79(10), 2674−2680. (SCI)
  25. Tung-Ying Wu, Fang-Rong Chang, Jing-Ru Liou, I-Wen Lo, Tang-Chia Chung,Li-Yao Lee, Ying-Chi Du, Man-Hon Wong, Suh-Hang Hank Juo, Chun-Chen Lee*, Yang-Chang Wu*, 2016. “Rapid hplc quantification approach for detection of active constituents in modern combinatorial formula, San-Huang-Xie-Xin-Tang (SHXXT).”Front. Pharmacol., 7, 374. (SCI)
  26. Barbara Tóth, Erika Liktor-Busa, Norbert Kúsz, ÁdámSzappanos, Attila Mándi, Tibor Kurtán, Edit Urbán, Judit Hohmann, Fang-Rong Chang*, and Andrea Vasas*, 2016. “Phenanthrenes from Juncusinflexus with antimicrobial activity against Methicillin-resistant Staphylococcus aureus.”J Nat Prod., 79(11), 2814–2823. (SCI)
  27. Kuei-Hung Lai,Mei-Chin Lu,Ying-Chi Du,Mohamed El-Shazly,Tung-Ying Wu,Yu-Ming Hsu,Astrid Henz,Juan-Cheng Yang, Anders Backlund*,Fang-Rong Chang*, Yang-Chang Wu*,2016. “Cytotoxic Lanostanoids from Poriacocos” J Nat Prod., 79(11),2805–2813. (SCI)
  28. Abdel Nasser B. Singab*, Iriny M. Ayoub, Mohamed El-Shazly, Michal Korinek, Tung-Ying Wu, Yuan-Bin Cheng, Fang-Rong Chang, Yang-Chang Wu, 2016. “Shedding the light on Iridaceae: Ethnobotany, phytochemistry and biological activity.”Ind Crops Prod., 92, 308–335. (SCI)
  29. SanthaseelanHenciya, PrabhaSeturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms,Fang-Rong Chang*, 2016. “Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa).”J. Food Drug Anal., 25(1), 187−196. (SCI)
  30. Barbara Tóth,Fang-Rong Chang, Tsong-Long Hwang,ÁdámSzappanos,Attila Mándi,Attila Hunyadi, Tibor Kurtán, GusztávJakab, Judit Hohmann,and Andrea Vasas*, 2017. “Screening of Luzula species native to the Carpathian Basin for anti-inflammatory activity and bioactivity-guided isolation of compounds fromLuzulaluzuloides (Lam.) Dandy & Wilmott.”Fitoterapia., 116, 131−138. (SCI)
  31. Kuei-Hung Lai,Mei-Chin Lu,Fang-Rong Chang,Jui-Hsin Su,Mohamed El-Shazly,Ying-Chi Du,Tung-Ying Wu,Yu-Ming Hsu,Anders Backlund, Yang-Chang Wu*, 2016. “Antileukemicsesterterpenoids from a marine sponge, Luffariella sp.”Planta Med.,81(S 01), S1-S381. (SCI)
  32. Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh*, and Fang-Rong Chang*, 2017. “6-Paradol and 6-Shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-Paradol reduces blood glucose in high-fat diet-fed mice.”Int. J. Mol. Sci., 18(1), 168. (SCI)
  33. Yung-Fong Tsai, Tzu-Chi Chu, Wen-Yi Chang, Yang-Chang Wu, Fang-Rong Chang, Shun-Chin Yang, Tung-Ying Wu, Yu-Ming Hsu, Chun-Yu Chen, Shih-Hsin Chang, Tsong-Long Hwang*, 2017. “6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury.”Free RadicBiol Med., 106, 379-392.(SCI)
  34. Chi-Ying Li, I-Wen Lo, Shih-Wei Wang, Tsong-Long Hwang, Yu-Ming Chung, Yuan-Bin Cheng, Sung-Pin Tseng, Yi-Hung Liu, Yu-Ming Hsu, Shu-Rong Chen, Hao-Chun Hu,Fang-Rong Chang*, Yang-Chang Wu*, 2017. “Novel 11-norbetaenone isolated from an entomopathogenic fungus Lecanicilliumantillanum.”Bioorg Med Chem Lett., 27(9), 1978-1982.(SCI)
  35. Halima MeriemIssaadi, Yu-Chi Tsai, Fang-Rong Chang, Attila Hunyadi*, 2017. “Centrifugal partition chromatography in the isolation of minor ecdysteroids from Cyanotisarachnoidea.”J Chromatogr B AnalytTechnol Biomed Life Sci., 1054, 44-49.(SCI)
  36. Hsiang-Lin Tsai, Chi-Jung Tai, Ching-Wen Huang, Fang-Rong Chang, Jaw-Yuan Wang*, 2017. “Efficacy of low-molecular-weight fucoidan as a supplemental therapy in metastatic colorectal cancer patients: a double-blind randomized controlled trial.”Mar Drugs., 15(4), 122. (SCI)
  37. Balázs Dankó,Szilárd Tóth,Ana Martins,VágvölgyiMáté,Norbert Kúsz,Joseph Molnár,Fang-Rong Chang,Yang-Chang Wu,GergelySzakács,Attila Hunyadi*, 2017. “Synthesis and SAR study of novel anticancer protoflavone derivatives - investigation of cytotoxicity and interaction with the ABCB1 and ABCG2 multidrug efflux transporters.”ChemMedChem.,12(11), 850-859.(SCI)
  38. Vitthal D. Wagh, Michal Korinek, I-Wen Lo, Yu-Ming Hsu, Shu-Li Chen, Hsue-Yin Hsu, Tsong-Long Hwang,Yang-Chang Wu,Bing-Hung Chen*,Yuan-Bin Cheng*, Fang-Rong Chang*, 2017. “Inflammation modulatory phorbol esters from the seeds of Aquilariamalaccensis.”J. Nat. Prod., 80, 1421−1427.(SCI)
  39. Yuan-Bin Cheng, Hao-Chun Hu, Yu-Chi Tsai, Shu-Li Chen, Mohamed El-Shazly, Maribel G. Nonato, Yang-Chang Wu*, Fang-Rong Chang*, 2017. “Isolation and absolute configuration determination of alkaloids from Pandanus amaryllifolius.”Tetrahedron., 73, 3423-3429. (SCI)