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Associate Research Fellow/Shiao, Young-Ji

Shiao, Young-JiCurrent position: Associate Research Fellow
E-mail: yshiao@nricm.edu.tw
Ph.D., Institute of Life Science, National Tsing Hua University
Major Professional Experiences
Postdoctoral research, Lipid and Lipoprotein Research Group, University of Alberta, Canada
Cell Biology, Biochemistry, Neuroscience
Research Description
Alzheimer's disease (AD) is also called senile dementia. The cause and progression of AD is not well understood, but is associated with plaques and tangles in the brain. No treatment has been found to stop or reverse the disease. AD is as yet not well understood at the molecular level. It has been identified as a protein misfolding disease due to the accumulation of abnormally folded Aβ protein in the brains of AD patients. Aβ, is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid precursor protein (APP). Aβ monomers are soluble and contain short regions of β sheet; however, at sufficiently high concentration, they undergo a dramatic conformational change to form a β sheet-rich tertiary structure that aggregates to form amyloid fibrils. These fibrils deposit outside neurons known as senile plaques. AD is also considered a tauopathy due to abnormal aggregation of the tau protein, a microtubule-associated protein expressed in neurons that normally acts to stabilize microtubules in the cell cytoskeleton. Like most microtubuleassociated proteins, tau is normally regulated by phosphorylation; however, in AD patients, hyperphosphorylated tau accumulates as paired helical filaments that in turn aggregate into masses inside nerve cell bodies known as neurofibrillary tangles and as dystrophic neurites associated with amyloid plaques. The advantages of Chinese herbal medicines on AD therapy come from its fewer side effects and multifunction. Clinically, the major usages of Chinese herbal medicines for the treatment of AD are those traditionally used for tonifying the kidney, regulating the heart and spleen, activating blood and resolving stasis, and tranquilizing and opening the orifices. Several single and multiple prescriptions have been investigated and were found possessing high potential for AD therapy. The long-term goals of this laboratory are to have a better understanding of the mechanism of AD pathogenesis, and investigating the potential of Chinese herbal medicines for AD therapy.
Published Papers
NCBI PubMed :  Young-Ji Shiao (Please click!!)
  1. Tzeng, T.-T., Chen, C.-C., Ni, C.-L., Lee, L.-Y., Chen, W.-P., Lu, C.-K., Huang, C.-Y.-F., Shen, C.-C., Chen, C.-C. & Shiao, Y.-J. (2016) Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic miceJournal of Biomedical Science 23:49.
  2. Tsay, H.-J., Huang. Y.-J., Chen, Y.-J., Lee, Y.-H., Hsu, S.-M., Tsai, K.-C., Yang, C.-N., Huang, F.-L., Shie, F.-S., Lee, L.-C. & Shiao, Y.-J. (2016) Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO. Journal of Biomedical Science 23:27.
  3. Chen, C.-C., Tzeng, T.-T., Chen, C.-C., Ni, C.-L., Lee, L.-Y., Chen, W.-P., Shiao, Y.-J. *, & Shen, C.-C.* (2016) Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus. Journal of Natural Product 79:438-441. *Correspondence.
  4. Shen, D.-Y., Nguyen, T.-N., Wu, S.-J., Shiao, Y.-J., Hung, H.-Y., Kuo, P.-C., Kuo, D.-H., Thang, T.-D., & Wu, T.-S. (2015) γ- and δ-Lactams from the Leaves of Clausena lansium. Journal of Natural Product 78:2521-2530.
  5. Yeh, C.-W., Yeh, S.-H.-H., Shie, S.-F., Lai, W,-S., Liu, H.-K., Tzeng, T.-T., Tsay, H.-J., & Shiao, Y.-J. (2015) Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice Corresponding. Neurobiology of Aging 36:2948-2994.
  6. Chen, H.-J., Shen, Y.-C., Shiao, Y.-J., Liou, K.-T., Hsieh, P.-H., Lee, C.-Y., Chen, Y.-R., & Lin, Y.-L. (2015) Multiplex brain proteomic analysis revealed the molecular therapeutic effects of Buyang Huanwu Decoction on cerebral ischemic stroke mice. PLoS One 10:e0140823.
  7. Shie, S.-F.*, Shiao, Y.-J.*, Yeh, C.-W., Lin, C.-H., Tzeng, T.-T., Hsu, H.-C., Huang, F.-L., Tsay, H.-J. & Liu, H.-K. (2015) Obesity and Hepatic Steatosis are associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice. PLoS One 10:e0134531. *contribution equally.
  8. Lin, Y.-L., Tsay, H.-J., Lai, T.-H., Tzeng, T.-T., & Shiao, Y.-J. (2015) Lithospermic acid attenuates MPP+-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways. Journal of Biomedical Science 22:37.
  9. Hsieh, J.-F., Lin, W.-J., Huang, K.-F., Liao, J.-H., Don, M.-J., Shen, C.-C., Shiao, Y.-J., & Li, W.-T. (2015) Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans. European Journal of Medical Chemistry 93:443-51.
  10. Tzeng, T.-T., Tsay, H.-J., Chang, L., Hsu, C.-L., Lai, Z.-H., Huang, F.-L., & Shiao, Y.-J. (2013) Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid. Journal of Biomedical Science 20:90.
  11. Tsay, H.-J., Huang, Y.-C., Huang, F.-L., Chen, C.-P., Tsai, Y.-C., Wang, Y.-H., Wu, M.-F., Chiang, F.-Y. & Shiao, Y.-J. (2013) Amyloid b peptide-mediated neurotoxicity is attenuated by the proliferating microglia more potently than by the quiescent phenotype. Journal of Biomedical Science 20:78.
  12. Wang, C.-J., Chen, C.-C., Tsay, H.-J., Chiang, F.-Y., Wu, M.-F., & Shiao, Y.-J. (2013) Cudrania cochinchinensis attenuates amyloid β protein-mediated microglial activation and promotes glia-related clearance of amyloid β protein. Journal of Biomedical Science 20:55.
  13. Huang, F.-L.*, Shiao, Y.-J.*, Hou, S.-J., Yang, C.-N., Chen, Y.-J., Lin, C.-H., Shie, F.-S., & Tsay, H.-J. (2013) Cysteine-rich domain of scavenger receptor AI modulates the efficacy of surface targeting and mediates oligomeric Aβ internalization. Journal of Biomedical Science 20:54. *contribution equally
  14. Lin, Y.-L., Tsay, H.-J., Liao, Y.-F., Wu, M.-F., Wang, C.-N. & Shiao, Y.-J. (2012) The components of Flemingia macrophylla attenuates amyloid beta-protein accumulation by regulating amyloid beta-protein metabolic pathway. Evidence-Based Complementary and Alternative Medicine. 2012:795843.


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