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沈郁強（Shen, Yuh-Chiang）

Current position：Research Fellow/Chief, Division of Clinical Chinese Medicine沈郁強實驗組合照
E-mail：yuhcs@nricm.edu.tw
 
Education：Ph.D., Institute of Pharmacology, National Yang-Ming University
 

Major Professional Experiences

1. Research Fellow, National Research Institute of Chinese Medicine 
2. Associate Research Fellow, National Research Institute of Chinese Medicine 
3. Assistant Research Fellow, National Research Institute of Chinese Medicine 
4. Adjunct Professor, National Taipei University of Nursing and Health Science 
5. Post Doctoral Fellow, Basic and Clinic Research, National Research Institute of Chinese Medicine 
6. Post Doctoral Fellow, Division of Cancer Research, National Health Research Institute 
7. Clinic Pharmacist, Department of Pharmacy, National Taiwan University Hospital 
 
Specialty
Elucidating anti-stroke drugs and mechanisms by traditional Chinese medicines (TCM), Leukocyte Cell and Molecular Biology, Inflammation Mechanism and Neuron Protection
 
Research Description

Dr. Yu-Chiang Shen has been dedicated to the development of Innovative Traditional Chinese Medicine (iTCM) and the modernization of herbal medicine. He has played a key role in leading the research team to successfully develop Taiwan Chingguan Yihau (NRICM101) and Taiwan Chingguan Erhao (NRICM102) and elucidate their pharmacological mechanisms. During the COVID-19 pandemic, these two groundbreaking herbal formulations made a significant impact: NRICM101 effectively prevented mild cases from worsening, while NRICM102 significantly reduced the mortality rate of severe cases by 74%, setting a global example of TCM’s role in major infectious disease control. Research findings have been published in the prestigious journal Pharmacological Research (IF 10.334), and the team has received numerous international and domestic awards, including the Taipei Biotech Award Gold Medal. NRICM101 has been adopted in over 60 countries, with more than 2 million subsidized prescriptions in Taiwan, generating over NT$10 billion in economic benefits, demonstrating its profound clinical and industrial impact.

Recently, Dr. Shen further demonstrated that NRICM101 is also effective against Influenza A and its variants, providing a preventive solution for severe influenza outbreaks in 2025. Additionally, using animal models and next-generation sequencing technologies, he has unraveled how NRICM formulations modulate innate immune responses, Toll-like receptors (TLR), JAK/STAT, PI3K/AKT, NET, and cytokine storms, ultimately reducing lung injury, immune overactivation, and thrombosis, showcasing remarkable antiviral and anti-inflammatory effects.

Dr. Shen has expanded the applications of NRICM formulations beyond COVID-19.

  • NRICM101 has been found effective in alleviating post-COVID brain fog, offering a much-needed therapeutic option for long COVID symptoms.
  • NRICM102 is being explored for treating multi-organ failure induced by Bongkrekic acid (a toxic foodborne compound) and chronic obstructive pulmonary disease (COPD), demonstrating superior anti-inflammatory and anti-fibrotic effects compared to steroids, addressing unmet medical needs in these conditions.

From COVID-19 Treatment to Breakthroughs in Neurodegenerative Diseases
Dr. Shen has further expanded his research into neurodegenerative diseases and stroke rehabilitation, leading the development of:

  • NRICM301 (Taiwan Xingnao Yihau): Focused on post-stroke recovery, this formulation has received patent applications in Taiwan and the U.S., successfully completed technology transfer, and entered product manufacturing, demonstrating the potential of TCM in treating major chronic diseases.
  • NRICM201 (Taiwan Qingnao Yihau): Targeted for dementia treatment, currently undergoing clinical trials and patent protection strategies.

Additionally, Dr. Shen is actively investigating the role of TCM in treating respiratory syncytial virus (RSV), human metapneumovirus (HMPV), dengue fever, and other infectious diseases leading to multi-organ failure, as well as its applications in insomnia, Parkinson’s disease, and dementia, achieving significant breakthroughs. These efforts have solidified Taiwan’s leadership in the global biotech and medical industries.

With his remarkable research achievements, Dr. Shen has been recognized as one of the world’s top 2% most-cited scientists in 2020, 2022, 2023, and 2024, according to Stanford University’s Global Scientific Influence Rankings, highlighting his profound impact on the international scientific community. His work not only provides effective and safe solutions for disease prevention and treatment but also drives the modernization of traditional medicine, successfully bringing NRICM’s innovations to the global stage through technology transfer, patent strategies, and international commercialization. His contributions are paving the way for a new era in Taiwan’s biotech and medical industries while advancing global healthcare innovation.
 

Publication (selected)

  1. Wei WC, Tsai KC, Liaw CC, Chiou CT, Tseng YH, Liao GY, Lin YC, Chiou WF, Liou KT, Yu IS, Shen YC(*), Su YC. NRICM101 ameliorates SARS-CoV-2-S1-induced pulmonary injury in K18-hACE2 mice model. Front Pharmacol. 2023 Jun 21;14:1125414. doi: 10.3389/fphar.2023.1125414. PMID: 37416063; PMCID: PMC10320700. (*), 共同責任作者 (臺灣清冠一號有效治療COVID19研究)
  2. Wei WC, Liaw CC, Tsai KC, Chiou CT, Tseng YH, Chiou WF, Lin YC, Tsai CI, Lin CS, Lin CS, Liou KT, Yu IS, Shen YC(*), Su YC. Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis. Pharmacol Res. 2022 Oct;184:106424. doi: 10.1016/j.phrs.2022.106424. Epub 2022 Sep 5. PMID: 36064077; PMCID: PMC9443660. (*),共同責任作者 (臺灣清冠二號有效治療COVID19重症研究)
  3. Chang CC, Wang YH, Yen JC, Liaw CC, Tsai KC, Wei WC, Chiou WF, Chiou CT, Liou KT, Shen YC(*), Su YC. NRICM101 in combatting COVID-19 induced brain fog: Neuroprotective effects and neurovascular integrity preservation in hACE2 mice. J Tradit Complement Med. 2024 Jul 3;15(1):36-50. doi: 10.1016/j.jtcme.2024.07.001. PMID: 39807266; PMCID: PMC11725119. (*), 共同責任作者 (臺灣清冠一號有效治療COVID後腦霧研究)
  4. Shen et al (2024). NRICM102: A Breakthrough in Treating Pulmonary Inflammation, Fibrosis, and COPD – A Multi-Target Approach to Respiratory Health. (臺灣清冠二號有效治療COPD研究; IP application)
  5. Shen et al (2024). Intervention of NRICM102 and N-acetylcysteine in mitigating hepatorenal toxicity and enhancing cellular defense against bongkrekic acid poisoning. (臺灣清冠二號有效治療邦克烈酸誘發肝腎衰竭研究; IP application)
  6. Chern CM, Lu CK, Liou KT, Wang YH, Tsai KC, Chang CL, Chang CC, Shen YC(*). Medicarpin isolated from Radix Hedysari ameliorates brain injury in a murine model of cerebral ischemia. J Food Drug Anal. 2021 Dec 15;29(4):581-605. doi: 10.38212/2224-6614.3377. PMID: 35649147; PMCID: PMC9931010. (*), 責任作者 (臺灣醒腦一號有效治療缺血型中風之研究1)
  7. Wang HW, Liou KT, Lin HJ, Shen YC(*). Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J Ethnopharmacol. 2011 Oct 31;138(1):22-33. doi: 10.1016/j.jep.2011.06.033. Epub 2011 Jul 8. PMID: 21784143. (*), 責任作者 (臺灣醒腦一號有效治療缺血型中風之研究2)
  8. Shen YC, Lu CK, Liou KT, Hou YC, Lin YL, Wang YH, Sun HJ, Liao KH, Wang HW. Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses. J Ethnopharmacol. 2015 Sep 15;173:370-82. doi: 10.1016/j.jep.2015.07.018. Epub 2015 Jul 31. PMID: 26239152. 第一作者 (中藥臨床驗方有效治療缺血型中風研究)

專利佈局

  1. 沙巴蛇草之萃取方法、其萃取物以及用於治療骨質疏鬆、神經退化性疾病、骨骼肌萎縮及促進傷口癒合之用途
  2. 治療或預防神經性疾病之藥物 (臺灣醒腦一號)
  3. 植物組成物、中草藥組成物在製備治療肺損傷藥物中之用途(臺灣清冠二號)
  4. 植物組成物、中草藥組成物及其用途 (臺灣清冠二號)
  5. USE OF PLANT COMPOSITION, TRADITIONAL CHINESE MEDICINE COMPOSITION IN PREPARING MEDICINE FOR TREATING COVID-19 (臺灣清冠二號)
  6. PLANT COMPOSITION, TRADITIONAL CHINESE MEDICINE COMPOSITION AND USE THEREOF (臺灣清冠二號)
  7. 牛膝萃取方法、牛膝萃取物、其用途及包含其之藥物組合
  8. A composition of Chinese medicine ingredients for treating neurodegenerative diseases (臺灣清腦一號)
  9. A composition of  food ingredients for use as a preventive, therapeutic, or ameliorating agent for acute central nervous system injuries and resulting sequelae (臺灣醒腦一號)。
     

Published Papers

NCBI PubMed :  Yuh-Chiang Shen (Please click!!)

  1. Liu SH, Huang HT, Lo IW, Lin YC, Liao GY, Chao CH, Huang HC, Chang FR, Li TL, Shen YC*, Liaw CC. Potential natural product 3,4-seco-schitriterpenoids from Kadsura japonica L. as anti-neuroinflammatory agents. Bioorg Chem. 2023 Sep 6;141:106843. doi: 10.1016/j.bioorg.2023.106843. Epub ahead of print. PMID:37696148.
  2. Lin SY, Chang CL, Liou KT, Kao YK, Wang YH, Chang CC, Kuo TBJ, Huang HT, Yang CCH, Liaw CC, Shen YC*. The protective role of Achyranthes aspera extract against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and PANoptosis. J Ethnopharmacol. 2023 Aug 28;319(Pt 1):117097. doi: 10.1016/j.jep.2023.117097. Epub ahead of print. PMID: 37648176.
  3. Chang SS, Huang HT, Wei WC, Lo IW, Lin YC, Chao CH, Liao GY, Shen YC, Chen JJ, Li TL, Lin LT, Tai CJ, Kuo YH, Liaw CC. Anti-inflammatory effect of euphane-and tirucallane-type triterpenes isolated from the traditional herb <i>Euphorbia neriifolia</i> L. Front Chem. 2023 Jun 23;11:1223335. doi: 10.3389/fchem.2023.1223335. PMID: 37426336; PMCID: PMC10326319.
  4. Wei WC, Tsai KC, Liaw CC, Chiou CT, Tseng YH, Liao GY, Lin YC, Chiou WF, Liou KT, Yu IS, Shen YC*, Su YC. NRICM101 ameliorates SARS-CoV-2-S1-induced pulmonary injury in K18-hACE2 mice model. Front Pharmacol. 2023 Jun 21;14:1125414. doi:10.3389/fphar.2023.1125414. PMID: 37416063; PMCID: PMC10320700.
  5. Huang HT, Lo IW, Liao GY, Lin YC, Shen YC, Huang HC, Li TL, Lee KT, Kuo YH, Liaw CC. Anti-inflammatory sesquiterpene and triterpene acids from <i>Mesona procumbens</i> Hemsley. Front Chem. 2022 Sep 15;10:1003356. doi: 10.3389/fchem.2022.1003356. PMID: 36186589; PMCID: PMC9520569.
  6. Wei WC, Liaw CC, Tsai KC, Chiou CT, Tseng YH, Chiou WF, Lin YC, Tsai CI, Lin CS, Lin CS, Liou KT, Yu IS, Shen YC*, Su YC. Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis. Pharmacol Res. 2022 Oct;184:106424. doi: 10.1016/j.phrs.2022.106424. Epub 2022 Sep 5. PMID: 36064077; PMCID: PMC9443660.
  7. Tseng YH, Lin SJ, Hou SM, Wang CH, Cheng SP, Tseng KY, Lee MY, Lee SM, Huang YC, Lin CJ, Lin CK, Tsai TL, Lin CS, Cheng MH, Fong TS, Tsai CI, Lu YW, Lin JC, Huang YW, Hsu WC, Kuo HH, Wang LH, Liaw CC, Wei WC, Tsai KC, Shen YC, Chiou WF, Lin JG, Su YC. Curbing COVID-19 progression and mortality with traditional Chinese medicine among hospitalized patients with COVID-19: A propensity score-matched analysis. Pharmacol Res. 2022 Oct;184:106412. doi: 10.1016/j.phrs.2022.106412. Epub 2022 Aug 23. PMID: 36007774; PMCID: PMC9395232.
  8. Chern CM, Lu CK, Liou KT, Wang YH, Tsai KC, Chang CL, Chang CC, Shen YC*. Medicarpin isolated from Radix Hedysari ameliorates brain injury in a murine model of cerebral ischemia. J Food Drug Anal. 2021 Dec 15;29(4):581-605. doi: 10.38212/2224-6614.3377. PMID: 35649147; PMCID: PMC9931010.
  9. Chen LL, Lee MH, Chang CL, Liou KT, Liu SH, Chern CM, Chen HI, Shen YC*, Wang YH. Suppression of Inflammatory and Fibrotic Signals by Cinnamon (<i>Cinnamomum cassia</i>) and Cinnamaldehyde in Cyclophosphamide-Induced Overactive Bladder in Mice. Evid Based Complement Alternat Med. 2021 Dec 22;2021:5205759. doi:10.1155/2021/5205759. PMID: 34976095; PMCID: PMC8716214.
  10. Kung YY, Kuo TBJ, Lai CT, Shen YC, Su YC, Yang CCH. Disclosure of suboptimalhealth status through traditional Chinese medicine-based body constitution and pulse patterns. Complement Ther Med. 2021 Jan;56:102607. doi: 10.1016/j.ctim.2020.102607. Epub 2020 Nov 19. PMID: 33220452.
  11. Chen LL, Shen YC, Ke CC, Imtiyaz Z, Chen HI, Chang CH, Lee MH. Efficacy of cinnamon patch treatment for alleviating symptoms of overactive bladder: A,double-blind, randomized, placebo-controlled trial. Phytomedicine. 2021 Jan; 80:153380. doi: 10.1016/j.phymed.2020.153380. Epub 2020 Oct 12. PMID: 33091856.
  12. Chern CM, Zhou H, Wang YH, Chang CL, Chiou WF, Chang WT, Yao CH, Liou KT, Shen YC*. Osthole ameliorates cartilage degradation by downregulation of NF-κB and HIF-2α pathways in an osteoarthritis murine model. Eur J Pharmacol. 2020 Jan15;867:172799. doi: 10.1016/j.ejphar.2019.172799. Epub 2019 Nov 22. PMID:31765607.
  13. Wang YH , Chern CM , Liou KT , Kuo YH , Shen YC* . Ergostatrien-7,9(11),22-trien-3β-ol from Antrodia camphorata ameliorates ischemic stroke brain injury via downregulation of p65NF-κ-B and caspase 3, and activation of Akt/GSK3/catenin-associated neurogenesis. Food Funct. 2019 Aug1;10(8):4725-4738. doi: 10.1039/c9fo00908f. Epub 2019 Jul 15. PMID: 31304955.
  14. Hsu WH, Shen YC, Shiao YJ, Kuo CH, Lu CK, Lin TY, Ku WC, Lin YL. Combined proteomic and metabolomic analyses of cerebrospinal fluid from mice with ischemic stroke reveals the effects of a Buyang Huanwu decoction in neurodegenerative disease. PLoS One. 2019 Jan 15;14(1):e0209184. doi: 10.1371/journal.pone.0209184. PMID: 30645580; PMCID: PMC6333407.
  15. Wang YH, Liou KT, Tsai KC, Liu HK, Yang LM, Chern CM, Shen YC*. GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice. Toxicol Appl Pharmacol. 2018 Oct 15;357:88-105. doi: 10.1016/j.taap.2018.08.023. Epub 2018 Sep 4. PMID: 30189238.
  16. Shen YC, Juan CW, Lin CS, Chen CC, Chang CL. NEUROPROTECTIVE EFFECT OF <i>TERMINALIA CHEBULA</i> EXTRACTS AND ELLAGIC ACID IN PC12 CELLS. Afr J Tradit Complement Altern Med. 2017 Jun 5;14(4):22-30. doi: 10.21010/ajtcam.v14i4.3. PMID: 28638863; PMCID: PMC5471469.
  17. Huang YL, Shen CC, Shen YC, Chiou WF, Chen CC. Anti-inflammatory and Antiosteoporosis Flavonoids from the Rhizomes of Helminthostachys zeylanica. J  Nat Prod. 2017 Feb 24;80(2):246-253. doi: 10.1021/acs.jnatprod.5b01164. Epub 2017 Feb 7. PMID: 28169537.
  18. Chien MY, Chuang CH, Chern CM, Liou KT, Liu DZ, Hou YC, Shen YC*. Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation  and apoptosis and the promotion of neurogenesis in mice. Free Radic Biol Med. 2016 Oct;99:508-519. doi: 10.1016/j.freeradbiomed.2016.09.006. Epub 2016 Sep 5. PMID: 27609227.
  19. Chen HJ, Shen YC*, Shiao YJ, Liou KT, Hsu WH, Hsieh PH, Lee CY, Chen YR, Lin YL. Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice. PLoS One. 2015 Oct 22;10(10):e0140823. doi: 10.1371/journal.pone.0140823. PMID: 26492191; PMCID: PMC4619651.
  20. Shen YC, Lu CK, Liou KT, Hou YC, Lin YL, Wang YH, Sun HJ, Liao KH, Wang HW. Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses. J Ethnopharmacol. 2015 Sep 15;173:370-82. doi: 10.1016/j.jep.2015.07.018. Epub 2015 Jul 31. PMID: 26239152.
  21. Wong YK, Chou MK, Shen YC, Wang YH, Yen JC, Chen CF, Lin SK, Liao JF. Preventive effect of baicalein on methamphetamine-induced amnesia in the passive avoidance test in mice. Pharmacology. 2014;93(5-6):278-85. doi: 10.1159/000365008. Epub 2014 Aug 21. PMID: 25170749.
  22. Hou YC, Lu CK, Wang YH, Chern CM, Liou KT, Wang HW, Shen YC*. Unique mechanisms of sheng yu decoction ( shèng yù tang) on ischemic stroke mice revealed by an integrated neurofunctional and transcriptome analysis. J Tradit Complement Med. 2013 Oct;3(4):240-9. doi: 10.4103/2225-4110.119703. PMID: 24716184; PMCID: PMC3925003.
  23. Chern CM, Wang YH, Liou KT, Hou YC, Chen CC, Shen YC*. 2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke. Biochem Pharmacol. 2014 Feb 1;87(3):502-14. doi: 10.1016/j.bcp.2013.11.018. Epub 2013 Dec 14. PMID: 24342702.
  24. Shen YC, Yen JC, Liou KT. Ameliorative effects of caffeic acid phenethyl ester on an eccentric exercise-induced skeletal muscle injury by down-regulating NF-κb mediated inflammation. Pharmacology. 2013;91(3-4):219-28. doi: 10.1159/000348412. Epub 2013 Apr 3. PMID: 23571777.
  25. Pan MY, Shen YC, Lu CH, Yang SY, Ho TF, Peng YT, Chang CC. Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines. Toxicol Appl Pharmacol. 2012 Dec 15;265(3):325-34. doi: 10.1016/j.taap.2012.08.034. Epub 2012 Sep 12. PMID: 22982536.
  26. Liao YR, Kuo PC, Liang JW, Shen YC, Wu TS. An efficient total synthesis of a potent anti-inflammatory agent, benzocamphorin F, and its anti-inflammatory activity. Int J Mol Sci. 2012;13(8):10432-10440. doi: 10.3390/ijms130810432. Epub 2012 Aug 21. PMID: 22949872; PMCID: PMC3431870.
  27. Lai JK, Wu HC, Shen YC, Hsieh HY, Yang SY, Chang CC. Krüppel-like factor 4 is involved in cell scattering induced by hepatocyte growth factor. J Cell Sci. 2012 Oct 15;125(Pt 20):4853-64. doi: 10.1242/jcs.108910. Epub 2012 Aug 1. PMID: 22854048.
  28. Chern CM, Liao JF, Wang YH, Shen YC*. Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice. Free Radic Biol Med. 2012 May 1;52(9):1634-47. doi: 10.1016/j.freeradbiomed.2012.01.030. Epub 2012 Feb 10. PMID: 22330064.
  29. Vijaya Bhaskar Reddy M, Shen YC, Ohkoshi E, Bastow KF, Qian K, Lee KH, Wu TS. Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents. Eur J Med Chem. 2012 Jan;47(1):97-103. doi: 10.1016/j.ejmech.2011.10.026. Epub 2011 Oct 20. PMID: 22115618.
  30. Hsu JW, Wang SJ, Lin CL, Hsieh WC, Lirng JF, Shen YC, Liao MH, Chou YH. Short term vs. long term test-retest reproducibility of ¹²³I-ADAM for the binding of serotonin transporters in the human brain. Psychiatry Res. 2011 Dec 30;194(3):224-229. doi: 10.1016/j.pscychresns.2011.04.011. Epub 2011 Nov 10.PMID: 22079655.
  31. Chang CC, Wang YH, Chern CM, Liou KT, Hou YC, Peng YT, Shen YC*. Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia. Toxicol Appl Pharmacol. 2011 Nov 15;257(1):137-47. doi: 10.1016/j.taap.2011.08.027. Epub 2011Sep 7. PMID: 21925195.
  32. Wang HW, Liou KT, Wang YH, Lu CK, Lin YL, Lee IJ, Huang ST, Tsai YH, Cheng YC, Lin HJ, Shen YC*. Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J Ethnopharmacol. 2011 Oct 31;138(1):22-33. doi: 10.1016/j.jep.2011.06.033. Epub 2011 Jul 8. PMID: 21784143.
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