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Assistant Research Fellow/Chiou, Chun-Tang

邱俊棠生活照Current Position:Research Fellow
Tel:2820-1999 ext. 7391、7531
E-Mailmklu@nricm.edu.tw
 
Education: Ph.D., Graduate Institute of Life Sciences, National Defense Medical Cencer
 
Major Professional Experiences
Postdoctoral Fellow, School of Pharmacy, College of Medicine, National Taiwan University
 
Specialty
Cell Biology, Drug Screening
 
Research Description
Cancer is the leading cause of death in the world. Though many anticancer drugs are used in clinical now, their undesired adverse effects encourage us to develop new therapeutic strategies to cure, prolong life, and improve quality of life for patients. Dysregulation of cell growth such as defects in cell cycle control and inactivation of apoptosis results in neoplasm formation. Therefore, activation of cell cycle checkpoints and reactivation of apoptosis are promising strategies for cancer therapy. We have established a serial of techniques,including a screen platform, cell biology and biochemistry methods for mechanism elucidation in vitro, and xenograft tumor model for efficacy validation in vivo to identify potential anticancer components from herbs and synthetic compounds. We have identified several synthetic compounds or pure compounds isolated form herbs that present good anticancer activity and are working on investigation of their anticancer mechanisms and in vivo efficacy evaluation. We hope we can develop valuable therapeutic drugs to combat cancer in the future.
 
Published Papers
NCBI PubMed :  Chun-Tang Chiou (Please click!!)
 
  1. Chiou, C.-T., Hsu, R.-Y., & Lin, L.-C. (2014). Isolation and cytotoxic effect of anthraquinones from Morinda umbellata. Planta Medica, 80(13), 1113-1117.  doi:10.1055/s-0034-1382956
  2. Chiou, C.-T., Kuo, Y.-H., Chan, Y.-Y., Juang, S.-H., Chan, H.-H., & Wu, T.-S. (2012). Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro. Phytochemistry, 80, 64-69. doi:10.1016/j.phytochem.2012.05.005
  3. Deore, R. R., Chen, G. S., Chang, P.-T., Chern, T.-R., Lai, S.-Y., Chuang, M.-H., . . . Chern, J.-W. (2012). Discovery of N-arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide derivatives as HCV NS5B polymerase inhibitors. ChemMedChem, 7(5), 850-860. doi:10.1002/cmdc.201200058
  4. Huang, H.-C., Chiou, C.-T., Hsiao, P.-C., Liaw, C.-C., Zhang, L.-J., Chang, C.-L., . . . Kuo, Y.-H. (2012). Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai. Molecules, 17(2), 1837-1851. doi:10.3390/molecules17021837
  5. Lee, Y.-H., Wei, C.-W., Wang, J.-J., & Chiou, C.-T. (2011). Rana catesbeiana ribonuclease inhibits Japanese encephalitis virus (JEV) replication and enhances apoptosis of JEV-infected BHK-21 cells. Antiviral Research, 89(3), 193-198.  doi:10.1016/j.antiviral.2011.01.002
  6. Zhang, L.J., Chiou, C.T., Cheng, J.J., Huang, H.C., Kuo, L.M., Liao, C.C., Bastow, K.F., Lee, K.H., Kuo, Y.H. (2010) Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica. J. Nat. Prod., 73:557–562.
  7. Chiou, C.T., Chen, G.S., Chen, M.L., Li, H., Shi, L., Huang, X.H., Dai, W.M., Chern, J.W.* (2010) Synthesis and anti-tumor mechanism study of N-(2-arylindol-7-yl)benzenesulfonamide derivatives. ChemMedChem, 5:1489–1497.
  8. Cheng, J.J., Zhang, L.J., Cheng, H.L., Chiou, C.T., Lee, I.J., Kuo, Y.H. (2010) Cytotoxic hexacyclic triterpene acids from Euscaphis japonica. J. Nat. Prod., 73:1655–1658.
  9. Lin, L.C., Chiou, C.T., Cheng, J.J. (2011) 5-Deoxyflavones with cytotoxic activity from Mimosa diplotricha. J. Nat. Prod., 74:2001–2004.
  10. Cheng, J. J., Zhang, L. J., Cheng, H. L., Chiou, C. T., Lee, I. J., and Kuo, Y. H. Cytotoxic hexacyclic triterpene acids from Euscaphis japonica. J. Nat. Prod. 73:1655–1658. [SCI]
  11. Chiou, C. T., Chen, G. S., Chen, M. L., Li, H., Shi, L., Huang, X. H., Dai, W. M., and Chern, J. W.* (2010). Synthesis and anti-tumor mechanism study of N-(2-arylindol-7-yl)benzenesulfonamide derivatives. ChemMedChem 5:1489-1497. [SCI]
  12. Zhang, L. J., Chiou, C. T., Cheng, J. J., Huang, H. C., Kuo, L. M., Liao, C. C., Bastow, K. F., Lee, K. H., and Kuo, Y. H. (2010). Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica. J. Nat. Prod. 73:557-562. [SCI]
  13. Chen, C, S., Chiou, C. T., Chen, G. S., S. C. Chen, C. Y. Hu, W. K. Chi, Y. D. Chu, L. H. Hwang, P. J. Chen, D. S. Chen, S. H. Liaw, and J. W. Chern. (2009). Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. J. Med. Chem. 52: 2716-2723. [SCI]
  14. Chiou, C. T., Hu, C. C. A., Chen, B. H., Liao, C. L., Lin, Y. L. and Wang, J. J. (2003). Association of Japanese encephalitis virus NS3 protein with microtubules and tumor susceptibility gene 101 (TSG101) protein. J. Gen. Virol. 84: 2795-2805. [SCI]
  15. Keng, N. T., Yin, F. Y., Chiou, C. T., Ratner, L. and Wang, J. J. (2003). Immunocytochemical evidence of the presence of CD4-Nef complexes on human T-cell surface enhances CD4 down-regulation. Chinese J. Infect. Dis. 21: 21-26.
  16. Chiou, C. T., Mai, R. T., Lam, C and Wang, J. J. (2002). Follicular dendritic cell damages with the expression of viral proteins in lymph nodes of HIV/AIDS patients. J. Med. Sci. 22: 109-118.
  17. Wang, J. J., Sandefur, S., Spearman, P., Chiou, C. T., Chiang, P. H. and Ratner, L. (2001). Tracking the assembly pathway of human immunodeficiency virus type 1 Gag deletion mutants by immunogold labeling. Appl. Immunohistochem. Mol. Morphol. 9: 371-379. [SCI]
  18. Chiou, C. T., Hu, H. M., Chuang, C. Y., Chen, Y. L., Liao, C. L., Chen, C. F., Gomez, V. F. and Wang, J. J. (2000). Detection of HIV proteins and genomes in lymph nodes of AIDS patients: evaluation of ELISA/Serodia assay for HIV serodiagnosis. J. Med. Sci. 20: 347-362.
  19. Wang, J. J., Liao, C. L., Yang, C. I., Chiou, C. T., and Chen, L. K. (1998). Localization of NS3 and E proteins in mouse brain infected with mutant strain of Japanese encephalitis virus. Arch. Virol. 143: 2353-2369. [SCI]
  20. Wang, J. J., Liao, C. L., Chiou, Y. W., Chiou, C. T., Huang, Y. L., and Chen, L. K. (1997). Ultrastructure and localization of E proteins in cultured neuron cells infected with Japanese encephalitis virus. Virology 238: 30-39. [SCI]

 
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