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Assistant Research Fellow/Wei, Wen-Chi

魏紋祈個人照Current Position:Assistant Research Fellow
Tel:2820-1999 ext. 3561、3551
E-Mailjackwei@nricm.edu.tw
Education
Ph.D., Department of Marine Biotechnology and Resources, National Sun Yat-sen University
Major Professional Experiences
Assistant Research Fellow, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taiwan
Postdoctoral fellow, Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
Specialty
Development of anti-inflammatory and anti-cancer activities of medicinal herbs
Tumor microenvironment and metastasis
Signal transduction in dendritic cells and MDSCs
Investigation of cancer immunotherapeutic effects of TCMs from Chinese medicine literatures

 
Research Description
The majority of cancer deaths are caused by metastases, not by orthotopic tumors. Therefore, understanding the mechanism of tumor metastasis and effective inhibition of tumor metastasis are recognized as a very important issue in cancer treatment. Myeloid-derived suppressor cells (MDSCs) are implicated in the promotion of tumor metastasis by protecting metastatic cancerous cells from immune surveillance and have thus been suggested as novel targets for cancer therapy. Research in our laboratory is focused on
(1) Elucidating the mechanism of tumor-induced differentiation of MDSCs and the role of MDSCs in tumor microenvironment and metastasis.
(2) Identifying master genes or signaling pathways in response to immunosuppression in MDSCs for targeted therapy.
(3) Developing anti-metastasis activity of Chinese and herbal medicines and their biotechnology applications.
(4) Assistance to editoral work of Journal of Chinese Medicine and integration of digital archives of Chinese medicine literatures

 
Journal Editor/Reviewer: 
Journal of Traditional and Complementary Medicine (中醫藥國際期刊JTCM) : reviewer

Australian Journal of Science and Technology : Editorial Board Member
Publications

       NCBI PubMed :  Wen-Chi Wei (Please click!!)
  1. Lin, S. Y., Hsieh, S. Y., Fan, Y. T., Wei, W. C., Hsiao, P. W., Tsai, D. H., Wu, T. S.*, and Yang, N. S.* (2017) Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance. Autophagy (Accepted)
  2. Wei, W. C., Lin, S. Y., Lan, C. W., Chen, Y. R., Yang, W. C., and Yang, N. S.* (2016) Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis. Scientific Reports 6, Article number: 36663. doi:10.1038/srep36663. (SCI)
  3. Lin, T. J., Liang, W. M., Hsiao, P. W., M. S. P, Wei, W. C., Lin, H. T., Yin SY, and Yang, N. S.* (2016) Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine. PLoS One, doi:10.1371/journal. pone.0138335. (SCI)
  4. Wei, W. C., Yang, W. C., Shyur, L. F., Sheu, J. H., Chen, S. S., and Yang, N. S.* (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced IL-12 expression in human dendritic cells. The Journal of Leukocyte Biology 97, 1071-1080. (SCI)
  5. Chang, W. T., Lai, T. H., Chyan, Y. J., Yin, S. Y., Chen, Y. H., Wei, W. C., and Yang, N.S.* (2015) Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis. PLoS One, doi: 10.1371/journal.pone.0122374. eCollection 2015. (SCI)
  6. Chang, F. Y., Hsu, F. J., Tai, C. J., Wei, W. C., Yang, N. S., and Sheu, J. H.* (2014) Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle. Marine Drugs 22, 3060-3071. (SCI)
  7. Wei, W. C., Wang, J. H., Aravindaram, K., Wang, S. J., Hsu, C. J. Li, Wen, C. C. Sheu, J. H., and Yang, N. S.* (2014) Polysaccharides from Dioscorea and other phytochemicals enhance anti-tumor effects induced by DNA vaccine against melanoma. Journal of Traditional and Complementary Medicine 4, 42-48.
  8. Wei, W. C., Sung, P. J., Duh, C. Y., Chen, B. W., Sheu, J. H.,* and Yang, N. S.* (2013) Anti-inflammatory activities of natural products isolated from soft corals of Taiwan between 2008 and 2012. Marine Drugs 11, 4083-4126. (SCI)
  9. Yin, S. Y., Wei, W. C., Jian, F. Y., and Yang, N.S. (2013) Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Alternat Med 302426. doi: 10.1155/2013/302426. (SCI)
  10. Chang, W. T., Chen, H. M., Yin, S. Y., Chen, Y. H., Wen, C. C., Wei, W. C., Lai, P., Wang, C. H., and Yang, N. S. (2013) Specific dioscorea phytoextracts enhance potency of TCL-loaded DC-based cancer vaccines. Evid Based Complement Alternat Med 932040. doi: 10.1155/2013/932040. (SCI)
  11. Arulselvan, P., Wen, C. C., Lan, C. W., Chen, Y. H., Wei, W. C., and Yang, N. S.* (2012) Dietary administration of scallion extract effectively inhibits colorectal tumor growth: Cellular and molecular mechanisms. PLoS One 7, e44658. doi:10.1371/journal.pone.0044658. (SCI)
  12. Wei, W. C., Lin, S. Y., Chen, Y. J. Wen, C. C., Huang, C. Y., Arulselvan, P., Sheu, J. H.,* and Yang, N. S.* (2011) Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin. Journal of Biomedical Science 18, 94 doi:10.1186/1423-0127-18-94. (SCI)
  13. Wei, W. C., Su, Y. H., Chen, S. S., Sheu, J. H., and Yang, N. S.* (2011) GM-CSF plays a key role in zymosan-stimulated human dendritic cells for activation of Th1 and Th17 cells. Cytokine 55, 79-89. (SCI)
  14. Wen, C. C., Chen, H. M., Chen, S. S., Huang, L. T., Chang, W. T., Wei, W. C., Chou, L. C., Arulselvan, P., Wu, J. B., Kuo, S. C.,* and Yang, N. S.* (2011) Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines. Journal of Biomedical Science 18, 44 doi: 10.1186/1423-0127-18-44. (SCI)
  15. 楊寧蓀、魏紋祈、黃郁婷、王倩俁 (2011) 維繫健康的抗病機制—免疫系統活化的秘密 科學月刊 42, 916-921.
Patents
  1. Yang, N. S., Wei, W. C., Lin, S. Y., Hsiao, P. W. and Chen, Y. R. Use of polyacetylenic glycosides for suppression of granulocytic myeloid-derived suppressor cell activities and tumor metastasis. (PCT/US2015/064841, WO2016094587 A1).
  2. Yang, N. S., Wang, J. H. and Wei, W. C. Dioscorea extracts for enhancing immune system. (US Patent Application No. US 7,972,645 B2/2011)
  3. Sheu, J. H., Yang, N. S., Wei, W. C., and Huang, C. Y. Marine diterpene excavatolide B and analogues for medical applications. (US Patent Application No. US 8530513 B1/2013)
  4. 許志宏 (Sheu, J. H.);楊寧蓀 (Yang, N. S.);魏紋祈 (Wei, W. C.);黃瓊瑤 (Huang, C. Y.)珊瑚BrD1雙萜化合物及其取代物於醫藥上之應用Pharmaceutical Uses of Diterpene BrD1 and Substituents Thereof From Corals. (中華民國專利編號:I448283)
 
Honors and Awards
  1. Taiwan Healthcare and Agricultural Biotech Industries Innovation and Excellence Awards:Innovation Potential Award (2014)
  2. Taiwan Healthcare and Agricultural Biotech Industries Innovation and Excellence Awards:Innovation Potential Award (2013)
 


 
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