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Assistant Research Fellow/Liaw, Chia-Ching

Liaw, Chia-Ching
Current Position:Assistant Research Fellow
Tel:2820-1999 ext. 2621、2531
E-mail : liawcc@nricm.edu.tw

Ph.D., Department of Marine Biotechnology and Resources, National Sun Yat-sen University

Major Professional Experiences
  1. Postdoctoral Fellow, National Research Institute of Chinese Medicine, Taipei, Taiwan.
  2. Postdoctoral Fellow, Department of Pharmacy, National Taiwan University, Taipei, Taiwan.
  3. R&D Manager, Starsci Biotech. Co., Ltd, Taipei, Taiwan.
Natural Product Chemistry, Phytochemistry, Spectrometric Chemistry, Quality Control of Chinese Herbs

  1. Chen, P.Y.; Chang, C.C.; Huang, H.C.; Zhang, L.J.; Liaw, C.C.; Lin, Y.C.; Nguyen, N.L.; Vo, T.H.; Cheng, Y.Y.; Morris-Natschke, S.L.; Lee, K.H.; Kuo, Y.H. New Dammarane-type Saponins from Gynostemma pentaphyllum. Molecules 2019, 24, 1375-1387.
  2. Ko, P.H.; Shen, Y.C.; Murugan, K.; Huang, C.W.; Sivakumar, G.; Pal, P.; Liao, C.C.; Luo, K.S.; Chuang, Y. E.; Tsai, M.H.; Lai, L.C. Macrophage Migration Inhibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9’-methyl-3’-carbazole)-3,4-dihydro-β-carboline. Sci. Rep. 2019, 9, 2147-2158.
  3. Kuo-Yang, L.M; Tseng, P.Y.; Lin, Y.C.; Liaw, C.C.; Zhang, L.J.; Tsai, K.C.; Lin, Z.H.; Ho, H.O.; Kuo, Y.H. New Hirsutinolide-type Sesquiterpenoids from Vernonia cinerea inhibit Nitric Oxide Production in LPS-Stimulated RAW264.7 Cells. Planta Med. 2018, 84, 1348-1354.
  4. Liu, M.; Chen, Y.L.; Kuo, Y.H.; Lu, M. K.; Liaw, C.C. Aqueous extract of Sapindus mukorossi induced cell death of A549 cells and exhibited antitumor property in vivo. Sci. Rep. 2018, 8, 4831-4845.
  5. Huang, H.C.; Chao, C.L.; Liaw, C.C.; Hwang, S.Y.; Kuo, Y.H.; Chang, T.C.; Chao, C.H.; Chen, C.J.; Kuo, Y.H. Hypoglycemic Constituents Isolated from Trapa natans L. Percarps. J. Agric. Food Chem. 2016, 64, 3794-3803.
  6. Wang, S.S.; Cheng, Y.B.; Lin, Y.C.; Liaw, C.C.; Chang, J.Y.; Kuo, Y.H.; Shen, Y.C. Nitrogen-containing Diterpenoids, Sesquiterpenoids, and Nor-diterpenoids from Cespitularia taeniata. Mar. Drugs 2015, 13, 5796-5814.
  7. Liaw, C.C.; Huang, H.C.; Hsiao, P.C.; Zhang, L.J.; Lin, Z.H.; Hwang, S.Y.; Hsu, F.L.; Kuo, Y.H. 5b,19-Epoxycucurbitnae Triterpenoids from Momordica charantia and Their Anti-inflammatory and Cytotoxic Activities. Planta Med. 2015, 81, 62-70.
  8. Lin, Y.C.; Chang, J.C.; Cheng, S.Y.; Wang, C.M.; Jhan, Y.L.; Lo, I.W.; Hsu, Y.M.; Liaw, C.C.; Hwang, C.C.; Chou C.H. New Bioactive Chromanes from Litchi chinensis. J. Agric. Food Chem. 2015, 63, 2472-2478.
  9. Liaw, C.C.; Cheng, Y.B.; Lin, Y.S.; Kuo, Y.H.; Hwang, T.L.; Shen, Y.C. New Briarane Diterpenoids from Taiwanese Soft Coral Briareum violacea. Mar. Drugs 2014, 12, 4677-4692. (IF : 3.772; Rank : 15/61)
  10. Zhang, L.J.; Liaw, C.C.; Hsiao, P.C.; Huang, H.C.; Lin, M.J.; Lin, Z.H.; Hsu, F.L.; Kuo, Y.H. Cucurbitane-type Glycosides from the Fruits of Momordica charantia and their Hypoglycaemic and Cytotoxic Activities. J. Func. Foods, 2014, 6, 564-574.
  11. Huang, H.C.; Hwang, S.Y.; Liang, Y.H.; Zhang Y.W.; Liaw, C.C.; Kuo, Y.H. Constituents from Taiwanese Sarcopyramis nepalensis. J. Chin. Med. 2013, 24, 1-12.
  12. Lin, Y.C.; Cheng, Y.B.; Liaw, C.C.; Lo, I.W.; Kuo, Y.H.; Chiang, M.Y.; Chou, C.H.; Shen, Y.C. New Lignans from the Leaves and Stems of Kadsura philippinensis. Molecules 2013, 18, 2042-2053.
  13. Liaw, C.C.; Lin, Y.C.; Lin, Y.S.; Chen, C.H.; Hwang, T.L.; Shen, Y.C. Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis. Mar. Drugs 2013, 11, 2042-2053.
  14. Liaw, C.C.; Chen, Y.C.; Fazary, A.E.; Hsieh, J.L.; Chen, S.Y.; Chien, C.T.; Sheu, S.Y.; Kuo,; Y.C. Shen, Y.C. A Novel Prenylated C6-C3 Compound with Estrogen-like Activity from the Fruits of Illicium arborescens. Phytochemistry Lett. 2013, 6, 397-402.
  15. Kuo Yang, L.M.; Zhang, L.J.; Huang, H.T.; Lin, Z.H.; Liaw, C.C.; Cheng, H.L.; Lee, K.H.; Morris-Natschke, S.L.; Kuo, Y.H.; Ho, H.O. Antioxidant Lignans and Chromone Glycosides from Eurya japonica. J. Nat. Prod. 2013, 76, 580-587.
  16. Cheng, H.L.; Zhang, L.J.; Liang, Y.H.; Hsu, Y.W.; Lee, I.J.; Liaw, C.C.; Hwang, S.Y.; Kuo, Y.H. Antiinflammatory and Antioxidant Flavonoids and Phenols from Cardiospermum halicacabum. J. Tradit. Complemen. Med. 2013, 3, 33-40.
  17. Hsiao, P.C.; Liaw, C.C.; Hwang, S.Y.; Cheng, H.L.; Zhang, L.J.; Shen, C.C.; Hsu, F.L.; Kuo, Y.H. Antiproliferative and Hypoglycemic Cucurbitane-type Glycosides from the Fruits of Momordica charantia. J. Agric. Food Chem. 2013, 61, 2979-2986.
  18. Chen, Y.C.; Liaw, C.C.; Cheng, Y.B.; Lin, Y.C.; Chen, C.H.; Huang, Y.T.; Liou, S.S.; Chen, S.Y.; Chien, C.T.; Lee, G.C.; Shen, Y.C. Anti-liver fibrotic lignans from fruits of Schisandra arisanensis and Schisandra sphenanthera. Bioorg. Med. Chem. Lett. 2013, 23, 880-885.
  19. Lo, I.W.; Lin, Y.C.; Liao, T.C.; Chen, S.Y.; Lin, P.H.; Chien, C.T.; Chang S.Y.; Shen, Y.C. Schisarisanlatones A and B: A New Class of Nortriterpenoids from the Fruits of Schisandra arisanensis. Food Chem. 2013, 136, 1095-1099.
  20. Hsu, L.C.; Hsu, Y.W.; Liang, Y.H.; Liaw, C.C.; Kuo, Y.H.; Pan, T.M. Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568. Molecules 2012, 17, 664-674.
  21. Huang, H.C.; Chiou, C.T.; Hsiao, P.C. Liaw, C.C.; Zhang, L.J.; Chang, C.L.; Chen, I.S.; Chen, W.C.; Lee, K.H.; Kuo, Y.H. Cytotoxic Phenlpropanoids and a New Triterpene, Turformosinic Acid, from Turpinia formosana Nakai. Molecules 2012, 17, 1837-1851.
  22. Zhang, L.J.; Cheng, J.J.; Liao, C.C.; Cheng, H.L.; Huang, H.T.; Kuo Yang, L.M.; Kuo Y.H. Triterpene Acids from Euscaphis japonica and Assessment of Their Cytotoxic and Anti-NO Activities. Planta Med. 2012, 78, 1584-1590.
  23. Chang, J.Y.; Liaw, C.C.; Fazary, A.E.; Hwang, T.L.; Shen, Y.C. New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea. Mar. Drugs 2012, 10, 1321-1330.
  24. Yeh, P.H.; Shieh, Y.D.; Hsu, L.C.; Kuo Yang, L.M.; Lin, J.H.; Liaw, C.C.; Kuo, Y.H. Naturally Occurring Cytotoxic [3’→8”]-Biflavonoids from Podocarpus nakaii. J. Tradit. Complemen. Med. 2012, 2, 220-226.
  25. Liu ,Y.W.; Cheng, Y.B.; Liaw, C.C.; Chen, C.H.; Guh, J.H.; Hwang, T.L.; Tasi, J.S.; Wang, W.B.; Shen, Y.C. Bioactive Diterpenes from Callicarpa longissima. J. Nat. Prod. 2012, 75, 689-693.
  26. Lee, I.J.; Huang, P.C.; Zhang, L.J.; Liaw, C.C.; Lin, M.R.; Yu, C.J.; Huang, C.I.; Kuo, Y.H. Investigation of Two Species of Huang-qi (Astragalus membranaceus and Hedysarum polybotrys) by HPLC, ITS, Microscopic Morphology and Antioxidant Activites. J. Food. Drug Anal. 2012, 20, 603-610.
  27. Huang, H.C.; Lin, Y.C.; Fazary, A.E.; Lo, I.W.; Liaw, C.C.; Huang, Y.Z.; Liou, S.S.; Shen, Y.C. New and Bioactive Lignans from the Fruits of Schisandra sphenanthera. Food Chem. 2011, 128, 348-357.
  28. Mendbayar, K.; Lo, I.W.; Liaw, C.C.; Lin, Y.C.; Fazary, A.E.; Kuo, Y.C.; Wang, H.J.; Chiang, B.H.; Liou, S.S.; Shen, Y.C. New and Bioactive Sesquiterpenes from Schisandra sphenanthera. Helv. Chim. Acta 2011, 94, 2295-2302.
  29. Shen, Y.C.; Chang, Y.T.; Lin, C.L.; Liaw, C.C.; Kuo, Y.H.; Tu, L.C.; Yeh, S.F.; Chern, J.W. Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carnazolyl-3,4-dihydro-b-carboline Analogs as Potential Antitumor Agents. Mar. Drugs 2011, 9, 256-277.
  30. Liaw, C.C.; Kuo, Y.H.; Lin, Y.S.; Hwang, T.L.; Shen, Y.C. Frajunolides L-O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis. Mar. Drugs 2011, 9, 1477-1486.
  31. Liu, C.C.; El-Razek, M.H.A.; Liaw, C.C.; Cheng, Y.B.; Chen, C.K.; Chien, C.T.; Kuo, Y.H.; Liou, S.S.; Shen, Y.C. Arisanschinins A-E, Lignans from Schisandra arisanensis Hay. Planta Med. 2010, 76, 1-6.
  32. Zhang, L.J.; Chiou, C.T.; Cheng, J.J.; Huang, H.C.; Kuo Yang, L.M.; Liao, C.C.; Bastow, K.F.; Lee, K.H. Kuo, Y.H. Cytotoxic Polyisoprenyl Benzophenonoids from Garcinia subelliptica. J. Nat. Prod. 2010, 73, 557-562.
  33. Lin, Y.S.; Chen, C.H.; Liaw, C.C.; Chen, Y.C.; Kuo, Y.H.; Shen, Y.C. Cembrane Diterpenoids from the Taiwanese Soft Coral Sinularia flexibilis. Tetrahedron 2009, 65, 9157-9164.
  34. Huang, S.Y.; Fan, L.Y.; Shen, Y.C.; Liao, C.C.; Hsu, L.C.; Hsu, Y.W.; Wu, T.S.; Hsiao, P.C.; Shen, C.C.; Don, M.J.; Kuo, Y.H. A New Dimeric Phenylpropanoid and Cytotoxic Norditerpene Constituents from Podocarpus nakaii. J. Asian Nat. Prod. Res. 2009, 11, 410-416.
  35. Luh, L.J.; Ei-Razek, M.H.A.; Liaw, C.C.; Chen, C.T.A.; Lin, Y.S.; Kuo, Y.H.; Chien, C.T.; Shen, Y.C. Tri- and Bicyclic Taxoids from the Taiwanese Yew Taxus sumatrana. Helv. Chem. Acta 2009, 92, 1349-1358.
  36. Kuo, Y.J.; Hwang, S.Y.; Wu, M.D.; Liao, C.C.; Liang, Y.H.; Kuo, Y.H.; Ho, H.O. Cytotoxic Constituents from Podocarpus fasciculus. Chem. Pharm. Bull. 2008, 56, 585-588.
  37. Huang, H.C.; Wu, M.D.; Tsai, W.J.; Liao, S.C.; Liaw, C.C.; Hsu, L.C.; Wu, Y.C.; Kuo, Y.H. Triterpenoid Saponins from the Fruits and Galls of Sapindus mukorossi. Phytochemistry 2008, 69, 1609-1616.
  38. Zhang, L.J.; Liao, C.C.; Huang, H.C.; Shen, Y.C.; Kuo, L.M.Y.; Kuo, Y.H. Antioxidant Phenylpropanoid Glycosides from Smilax bracteata. Phytochemistry, 2008, 69, 1398-1404.
  39. Lin, Y.S.; Khalil, A.T.; Chiou, S.H.; Kuo, Y.C.; Cheng, Y.B.; Liaw, C.C.; Shen Y.C. Bioactive Marine Prostanoids from Octocoral Clavularia viridis. Chem. & Biodiver. 2008, 5, 784-792.
  40. Shen, Y.C.; Lin, Y.C.; Cheng, Y.B.; Chang, C.J.; Lan, T.W.; Liou, S.S.; Chien, C.T.; Liaw, C.C.; Khalil, A.T. New Oxygenated Lignans from Kadsura philippinensis. Helv. Chim. Acta 2008, 91, 483-494.
  41. Huang, H.C.; Liaw, C.C.; Zhang, L.J.; Ho, H.U.; Yang, L.M.; Shen, Y.S.; Kuo, Y.H. Triterpenoidal Saponins from Hydrocotyle sibthorpioides. Phytochemistry 2008, 69, 1597-1603.
  42. Liaw, C.C.; Shen, Y.C.; Lin, Y.S.; Hwang, T.L.; Kuo, Y.H.; Khalil, A.T. Frajunolides E-K, Briarane Diterpenes from Junceella fragilis. J. Nat. Prod. 2008, 71, 1551-1556.
  43. Liaw, C.C.; Kuo, Y.H.; Hwang, T.L.; Shen, Y.C. Eupatozansins A-C, Sesquiterpene Lactones from Eupatorium chinense var. tozanense. Helv. Chem. Acta 2008, 91, 2115-2121.
  44. Shen, Y.C.; Cheng, Y.B.; Lan, T.W.; Liaw, C.C.; Liou, S.S.; Kuo, Y.H.; Khalil, A.T. Kadsuphilols A-H, Oxygenated Lignans from Kadsura philippinensis. J. Nat. Prod. 2007, 70, 1139-1145.
  45. Shen, Y.C.; Lin, Y.C.; Farzary, A.D.; Cheng, Y.B.; Liaw, C.C.; Kuo, Y.H. Four New Nonaoxygenated C18 Dibenzocylcooctadiene Lignans from Kadsura philippinensis. Chem. Pharm. Bull. 2007, 55, 280-283.
  46. Huang, H.C.; Tsai, W.J.; Liaw C.C.; Wu, S.H.; Wu, Y.C.; Kuo, Y.H. Anti-platelet Aggregation Triterpene Saponins from the Galls of Sapindus mukorossi. Chem. Pharm. Bull. 2007, 55, 1412-1415.
  47. Shen, Y.C.; Liaw, C.C.; Cheng, Y.B.; Ahmed, A. F.; Lai, M.C.; Liou, S.S.; Wu, T.S.; Kuo, Y.H.; Lin, Y.C. C18 Dibenzocyclooctadiene Lignans from Kadsura philippinensis. J. Nat. Prod. 2006, 69, 963-966.
  48. Shen, Y.C.; Liaw, C.C.; Ho, J.R.; Khalil, A.T.; Kuo, Y.H.; Isolation of Aureol from Smenospongia sp. and Cytotoxic activity of Some Aureol Derivatives. Nat. Prod. Res. 2006, 20, 578-585.
  49. Shen, Y.C.; Lin, Y.C.; Cheng, Y.B.; Kuo, Y.H.; Liaw, C.C. Taiwankadsurins A, B, and C, Three New C19 Homolignans from Kadsura philippinensis. Org. Lett. 2005, 7, 5297-5300.
  50. Kuo, Y.H.; Hsu, Y.W.; Liaw, C.C.; Lee, J. K.; Huang, H.C.; Kuo, L.M.Y. Cytotoxic Phenylpropanoid Glycosides from the Stems of Smilax china. J. Nat. Prod. 2005, 68, 1475-1478.
  51. Shen, Y.C.; Lin, Y.C.; Chiang, M.Y.; Yeh, S.F.; Cheng, Y.B.; Liao, C.C., Kadsuphilactones A and B, Two New Triterpene Dilactones from Kadsura philippinensis. Org. Lett. 2005, 7, 3307-3310.
  52. Kuo, Y.H.; Wu, M.D.; Huang, R.L.; Kuo, L.M.; Hsu, Y.W.; Liaw, C.C., Hung, C.C.; Shen, Y.C.; Ong, C.W. Antihepatitis Activity (Anti-HBsAg and Anti-HBeAg) of C19 Homolignans and Six Novel C18 Dibenzocyclooctadiene Lignans from Kadsura japonica. Planta Med. 2005, 71, 646-653.
  53. Kuo, L.M.; Chen, K.Y.; Hwang, S.Y.; Chen, J.L.; Liu, Y.Y.; Liaw, C.C.; Ye, P.H.; Chou, C.J.; Shen, C.C.; Kuo, Y.H. DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum. Planta Med. 2005, 71, 77-79.
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