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鄭靜枝（Cheng, Jing-Jy）

Cheng, Jing-JyCurrent position: Associate Research Fellow
E-mail: verona@nricm.edu.tw

 

Education
1993-1998  
Ph.D. Graduate Institute of Life Sciences National Defense Medical Center
1991-1993  
M.S.   Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University
1987-1991  
B.S., Department of Pharmacy, China Medical University

 

Major Professional Experiences
Postdoctoral Fellow (1998-2002), Institute of Biomedical Sciences, Academia Sinica
Adjunct Assistant Professor, Institute of Biophotonics, National Yang-Ming University

 

Specialty
Angiogenesis, Cancer, Endothelial Biology, Signal Transduction, Cell Biology.

 

Research Description
Endothelial cells are involved in many aspects of vascular biology, including in maintaining normal vascular functions and in participating in pathological process such as inflammation, cardiovascular disorder, and angiogenesis. Angiogenesis is a normal process in growth and development, as well as in wound healing. However, this is also a fundamental step in the transition of tumors from a dormant state to a malignant state. Therefore, my major research interest gradually shifted from discovery of vascular endothelial protection components to anti-angiogenic agents and further extended to cancer therapeutic agent development. Basic molecular techniques and several in vitro and in vivo models were established. Now I also manage and execute the services of Cancer Therapy Core Facility in our Institute since 2008. My research areas include:

(1)  
Studying for endothelial protective components on targeting JAK-STAT pathway and genes related to inflammation process.
(2)  
Development of anti-angiogenic components from synthetic compounds, natural products and fermentation products. In vitro and in vivo models were well established.
(3)  
Development of anti-cancer agents from natural product and synthetic compounds. Xenograft human lung cancer model was established. Target therapy on NOTCH pathway is ongoing for new therapeutic agent development.

 

Published Papers
NCBI PubMed :  Jing-Jy Cheng (Please click!!)
  1. Mar, A.-C., Chu, C.-H., Lee, H.-J., Chien, C.-W., Cheng, J.-J., Yang, S.-H., . . . Lee, T.-C. (2015). Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of IL-6 and VEGF-A in Colon Cancer Cells and Induce Angiogenesis. The Journal of Biological Chemistry. doi:10.1074/jbc.M115.644823
  2. Solum, E. J., Cheng, J.-J., Sørvik, I. B., Paulsen, R. E., Vik, A., & Hansen, T. V. (2014). Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis. European Journal of Medicinal Chemistry, 85, 391-398. doi:10.1016/j.ejmech.2014.08.002
  3. Cheng, J. J. (2012). Caffeic Acid Phenethyl Ester Suppresses IFN-γ-Induced STAT1 Activation and Gene Expression in Endothelial Cells. Journal of Chinese Medicine, 23(2), 103-112.
  4. Cheng, J.-J., Tsai, T.-H., & Lin, L.-C. (2012). New Alkaloids and Cytotoxic Principles from Sinomenium acutum. Planta Medica, 78(17), 1873-1877. doi:10.1055/s-0032-1327785
  5. Øyvind, W. A., Odlo, K., Cheng, J.-J., Maccari, G., Botta, M., & Hansen, T. V. (2012). Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1. Bioorganic & Medicinal Chemistry, 20(1), 234-242. doi:10.1016/j.bmc.2011.11.010
  6. Shen, C.-C., Cheng, J.-J., Lay, H.-L., Wu, S.-Y., Ni, C.-L., Chen, C.-C., & Teng, C.-M. (2012). Cytotoxic apigenin derivatives from Chrysopogon aciculatis. Journal of Natural Products, 75(2), 198-201. doi:10.1021/np2007796
  7. Zhang, L.-J., Cheng, J.-J., Liao, C.-C., Cheng, H.-L., Huang, H.-T., Kuo, L.-M. Y., & Kuo, Y.-H. (2012). Triterpene Acids from Euscaphis japonica and Assessment of Their Cytotoxic and Anti-NO Activities. Planta Medica, 78(14), 1584-1590. doi:10.1055/s-0032-1315040
  8. Cheng, J.-J., Lu, M.-K., Lin, C.-Y., & Chang, C.-C. (2011). Characterization and functional elucidation of a fucosylated 1,6-α-D-mannogalactan polysaccharide from Antrodia cinnamomea. Carbohydrate Polymers, 83(2), 545-553. doi:10.1016/j.carbpol.2010.08.016
  9. Lin, L.-C., Chiou, C.-T., & Cheng, J.-J. (2011). 5-Deoxyflavones with cytotoxic activity from Mimosa diplotricha. Journal of Natural Products, 74(9), 2001-2004. doi:10.1021/np200307r
  10. Chen, S.C., Lin, Y.L., Lin, S.J., Wang, D.L., Cheng, J.J.* (2011) Salvianolic acid B suppresses IFN-γ-induced JAK/STAT1 activation in endothelial cells. Thromb. Res., 128:560–564.
  11. Lu, M.K.*, Cheng, J.J.*, Lin, C.Y., Chang, C.C. (2010) Purification, structural elucidation, and anti-inflammatory effect of a water-soluble 1,6-branched 1,3-α-d-galactan from cultured mycelia of Poria cocos. Food Chem., 118:349–356. (* equal contribution)
  12. Cheng, J.J., Zhang, L.J., Cheng, H.L., Kuo, Y.H. (2010) Cytotoxic hexacyclic triterpene acids from Euscaphis japonica. J. Nat. Prod., 73:1655–1658.
  13. Lu, M.K.#, Cheng, J.J.#, Lin, C.Y., and Chang, C.C. (2010) Purification, structural elucidation, and antiinflammatory effect of a water-soluble 1,6-branched 1,3-α-d-galactan from cultured mycelia of Poria cocos. Food Chem., 118, 349-356. (# equal contribution)
  14. Cheng, J.J., Huang, N.K., Lur, H.S., Kuo, C.I., Lu, M.K. (2009) Characterization and biological functions of sulfated polysaccharides from sulfated-salt treatment of Antrodia cinnamomea. Process Biochem., 44:453–459.
  15. Cheng, J.J., Lur, H.S., Huang, N.K., Chen, H.P., Lin, C.Y., Lu, M.K. (2009) Exploring the potential of biopharmaceutical production by Rigidoporus ulmarius: cultivation, chemistry, and bioactivity studies. Process Biochem., 44:1237–1244.
  16. Cheng, J.J., Lin, C.Y., Lur, H.S., Chen, H.P., Lu, M.K. (2008) Properties and biological functions of polysaccharides and ethanolic extracts isolated from medicinal fungus, Fomitopsis pinicola. Process Biochem., 43:829–834.
  17. Cheng, J.J., Lin, C.Y., Lur, H.S., Chen, H.P., and Lu, M.K. (2008) Production, characterization and functions of polysaccharides and ethanolic extract isolated from medicinal fungus Fomitopsis pinicola. Process Biochem., 43, 829-834.
  18. Lu, M.K., Cheng, J.J., Lai, W.L., Lin, Y.R., and Huang, N.K. (2008) Fermented Antrodia cinnamomea extract prevents rat PC12 cells from serum deprivation-induced apoptosis. J. Agri. Food Chem., 56, 865-874.
  19. Lee, M.S., Cheng, J.J., Lin, C.Y., Chen, Y.J., and Lu, M.K.* (2007) Precursor feeding strategy for the production of solanine, solanidine and solasodine by a cell culture of Solanum lyratum. Process Biochem., 42, 899-903.
  20. Chen, S.C., Chang, Y.L., Wang, D.L., Cheng, J.J.* (2006) Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells. Br. J. Pharmacol., 148:226–232.
  21. Lu, M.K., Cheng, J.J.#, Lai, W.L., Lin, Y.R., and Huang, N.K. (2006) Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A2A receptors. Life Sci., 79, 252-258. (# Equally contribute)
  22. Chen, S.C., Lu, M.K., Cheng, J.J., and Wang, D.L. (2005) Antiangiogenic activities of polysaccharides isolated from medical fungi. FEMS Microbiol. Lett., 249, 247-254.
  23. Cheng, J.J., Huang, N.K., Chang, T.T., Wang, D.L., and Lu, M.K. (2005) Study for anti-angiogenic activities of polysaccharides isolated from Antrodia camphorata in endothelial cells. Life Sci., 76, 3029-3042.
  24. Cheng, J.J., Yang, C.J., Cheng, C.H., Wang, Y.T., Huang, N.K., and Lu, M.K. (2005) Characterization and functional study of Antrodia camphorata lipopolysaccharide. J. Agri. Food Chem., 53, 469-474.

 

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