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Research Fellow/Chief/Don, Ming-Jaw

董明兆實驗室生活照Current position：Research Fellow/Chief, Division of Chinese Medicinal Chemistry
E-mail：mjdon@nricm.edu.tw
Tel： (886-2)2820-1999 ext. 8411、8401
Fax：(886-2)2826-4276
 
Education : Ph.D., Department of Chemistry, University of North Texas, U.S.A.
 
Major Professional Experiences
Associate Research Fellow, National Research Institute of Chinese Medicine
Visiting Associate Research Fellow, National Research Institute of Chinese Medicine
Postdoctoral Fellow, Department of Chemistry, University of North Texas, U.S.A.
 
Specialty
Organic Chemistry, Medicinal Chemistry, Natural Products
 
Research Description
My research interests focus on the field of medicinal and natural product chemistry including the isolation and structural elucidation of natural products from traditional Chinese medicine (TCM), analytical evaluation of herbal medicine, total synthesis of biologically active natural product, and design and development of anticancer drugs. My research involves a wide range of spectroscopic techniques, including 1D and 2D-NMR, FT-IR, and LC/MS analyses.
 
 
Published papers
NCBI PubMed :  Ming-Jaw Don (Please click!!)
  1. Don, M.-J., Lin, L.-C., & Chiou, W.-F. (2012). Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells. Phytomedicine, 19(6), 551-561. doi:10.1016/j.phymed.2012.01.006
  2. Shen, M.-Y., Liu, Y.-J., Don, M.-J., Liu, H.-Y., Chen, Z.-W., Mettling, C., . . . Yang, W.-C. (2012). Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica. PLoS ONE, 6(11). doi:10.1371/journal.pone.0027480
  3. Chen, T.-H., Yu, H.-J., Lai, T.-C., Chiou, W.-F., & Don, M.-J. (2011). Synthesis and anti-inflammatory effect of four rutaecarpine metabolites. Journal of Chinese Medicine, 22, 37-46.
  4. Chiou, W.-F., Don, M.-J., Liao, J.-F., & Wei, B.-L. (2011). Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways. European Journal of Pharmacology, 650(1), 102-109. doi:10.1016/j.ejphar.2010.10.004
  5. Sun, C.M., Lin, L.G., Yu, H.J., Cheng, C.Y., Tsai, Y.C., Chu, C.W., Din, Y.H., Chau, Y.P., and Don, M.J.*(2007) Synthesis and cytotoxic activities of 4,5-Diarylisoxazoles. Bioorg. Med. Chem. Lett., 17, 1078-1081.
  6. Don, M.J., Liao, J.F., Lin, L.Y., and Chiou, W.F.* (2007) Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of PI3K signaling pathway. Br. J. Pharm., 151, 638-646.
  7. Don, M.J., Ko, H.C., Yang, C.W., and Lin, Y.L.* (2006) Detection of polyphenols and tanshinones in commercial danshen by liquid chromatography with UV and mass spectrometry. J. Food Drug Anal., 14,254-259.
  8. Don, M.J., Shen, C.C., Syu, W.J., Ding, Y.H., and Sun, C.M.* (2006) Cytotoxic and aromatic constituents from Salvia miltiorrhiza. Phytochemistry, 67, 497-503.
  9. Sun, C.M., Chin, T.M., Lin, Y.L., Chen, C.J., Chen, W.C., Wu, T.S., and Don, M.J.* (2006) Isolation, structure elucidation, and syntheses of isoneocryptotanshinone II and tanshinlactone A from Salvia miltiorrhiza. Heterocycles, 68, 247-255.
  10. Don, M.J., Shen, C.C., Lin, Y.L., Syu, W.J., Ding, Y.H., and Sun, C.M.* (2005) Nitrogen-containing compounds from Salvia miltiorrhiza. J. Nat. Prod., 68, 1066-1070.
  11. Ueng, Y.F., Yu, H.J., Lee, C.H., Peng, C., Jan, W.C., Ho, L.K., Chen, C.F., and Don, M.J.* (2005) Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa. J. Chromatogr. A, 1076, 103-109.
  12. Chiou, W.F., Shen, C.C., Yu, H.J., Chiang, C.H., Chen, C.C., Chang, W., and Don, M.J.* (2005) Total synthesis and antioxidative activity of magnolamide from Magnolia coco. Heterocycles, 65, 1215-1220.
  13. Lee, Y.T., Don, M.J., Hung, P.S., Shen, Y.C., Lo, Y.S., Chang, K.W., Chen, C.F., and Ho, L.K.* (2005) Cytotoxicity of phenolic acid phenethyl esters on oral cancer cells. Cancer Lett., 223, 19-25.
  14. Lee, Y.T., Don, M.J., Liao, C.H., Chiou, H.W., Chen, C.F., and Ho, L.K.* (2005) Effects of phenolic acid esters and amides on stimulus-induced reactive oxygen species production in human neutrophils. Clin. Chim. Acta, 352, 135-141.
  15. Lin, C.N., Syu, W.J., Sun, W.S., Chen, J.W., Chen, T.H., Don, M.J.*, Wang, S.H.* (2010) A role of ygfZ in the Escherichia coli response to plumbagin challenge. J. Biomed. Sci., 17:84.

 

 

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