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Research Fellow/Chief/ Lin, Lie-Chwen

Lin, Lie-ChwenCurrent position: Research Fellow /Chief, Division of Chinese Materia Medica Development
E-mail: lclin@nricm.edu.tw
 
Education
Ph.D., Graduated Institute of Pharmaceutical Sciences, Taipei Medical University, Taipei, Taiwan
 
Major Professional Experiences
1.
Associate Research Fellow, Division of Medicinal Chemistry, National Research Institute of Chinese Medicine
2.
Research Fellow, Division of Herbal Medicine, National Research Institute of Chinese Medicine
3.
Adjunct Associate Professor, Institute of Traditional Medicine, National Yang-Ming University
4.
Adjunct Associate Professor, Graduate Institute of Integrated Medicine, China Medical University
 
Specialty
Natural Product Chemistry, Analytical Chemistry
 
Research Description
In the face of modern medical dilemma, asking for advice on the nature has become an important trend. Natural product is biological diversity, is also in possession of chemical diversity. Natural products include many classes of compounds such as terpenoids, polyketides, alkaloids, flavonoids, peptides, proteins, carbohydrates, lipids, nucleic acid bases, ribonucleic acid (RNA), deoxyribonucleic acid (DNA), and so forth. In the battle against the new disease or improving on medical benefits, the results of natural product studies often draw a cheer. Like the promotion microvascular blood flow of Ginkgo biloba extract, the antimalarial Artemisinin, the anticancer Taxol, the anti-inflammatory Andrographolides, the anti-depression Hypericine, etc., are all examples of successes. The goals of this laboratory are to purify and characterize of bioactive molecules from medicinal plants. In addition, preparative study and quality control of bioactive molecules have also been explored.
 
Published Papers
NCBI PubMed :  Lie-Chwen Lin (Please click!!)
  1. Hou, M.-L., Lin, C.-H., Lin, L.-C., & Tsai, T.-H. (2015). The drug-drug effects of rhein on the pharmacokinetics and pharmacodynamics of clozapine in rat brain extracellular fluid by in vivo microdialysis. Journal of Pharmacology and Experimental Therapeutics, 354(3). doi:10.1124/jpet.115.225763
  2. Chiou, C.-T., Hsu, R.-Y., & Lin, L.-C. (2014). Isolation and cytotoxic effect of anthraquinones from Morinda umbellata. Planta Medica, 80(13), 1113-1117. doi:10.1055/s-0034-1382956
  3. Ho, J.-K., Huo, T.-I., Lin, L.-C., & Tsai, T.-H. (2014). Pharmacokinetics of ractopamine and its organ distribution in rats. Journal of Agricultural and Food Chemistry, 62(38), 9273-9278. doi:10.1021/jf5026168
  4. Hou, M.-L., Chang, L.-W., Lin, C.-H., Lin, L.-C., & Tsai, T.-H. (2014). Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes. Journal of Ethnopharmacology, 155(2), 1291-1299. doi:10.1016/j.jep.2014.07.022
  5. Hou, M.-L., Chang, L.-W., Lin, C.-H., Lin, L.-C., & Tsai, T.-H. (2014). Determination of bioactive components in Chinese herbal formulae and pharmacokinetics of rhein in rats by UPLC-MS/MS. Molecules, 19(4), 4058-4075. doi:10.3390/molecules19044058
  6. Lu, C.-M., Hou, M.-L., Lin, L.-C., & Tsai, T.-H. (2014). Development of a microdialysis system to monitor lamivudine in blood and liver for the pharmacokinetic application in herbal drug interaction and the gene expression in rats. Journal of Pharmaceutical and Biomedical Analysis, 96, 231-240. doi:10.1016/j.jpba.2014.04.001
  7. Lu, C.-M., Lin, L.-C., & Tsai, T.-H. (2014). Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. Molecules, 19(12), 21560-21578. doi:10.3390/molecules191221560
  8. Wu, Y.-T., Lin, L.-C., & Tsai, T.-H. (2014). Determination of rhynchophylline and hirsutine in rat plasma by UPLC-MS/MS after oral administration of Uncaria rhynchophylla extract. Biomedical Chromatography, 28(3), 439-445. doi:10.1002/bmc.3052
  9. Cheng, S., Lin, L.-C., Lin, C.-H., & Tsai, T.-H. (2013). Comment on pharmacokinetics and urine metabolite identification of dehydroevodiamine in the rat: From Boymia ruticarpa A. Juss. to Tetradium ruticarpum (A. Juss.) T.G. Hartley. Journal of Agricultural and Food Chemistry, 61(2), 472-472. doi:10.1021/jf304788k
  10. Hsueh, T. Y., Wu, Y.-T., Lin, L.-C., Chiu, A. W., Lin, C.-H., & Tsai, T.-H. (2013). Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim extract on the pharmacokinetics of sildenafil in rats. Molecules, 18(6), 7323-7335. doi:10.3390/molecules18067323
  11. Lin, L.-C., Tsai, T.-H., & Kuo, C.-L. (2013). Chemical constituents comparison of Codonopsis tangshen, Codonopsis pilosula var. modesta and Codonopsis pilosula. Natural Product Research, 27(19), 1812-1815. doi:10.1080/14786419.2013.778849
  12. Lu, C.-M., Hou, M.-L., Lin, L.-C., & Tsai, T.-H. (2013). Chemical and physical methods to analyze a multicomponent traditional Chinese herbal prescription using LC-MS/MS, electron microscope, and congo red staining. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2013/952796
  13. Wan-Ling, C.-L., Hou, M.-L., Chang, L.-W., Lee, C.-J., Tsai, Y.-M., Lin, L.-C., & Tsai, T.-H. (2013). Determination and pharmacokinetics of di-(2-ethylhexyl) phthalate in rats by ultra performance liquid chromatography with tandem mass spectrometry. Molecules, 18(9), 11452-11466. doi:10.3390/molecules180911452
  14. Cheng, J.-J., Tsai, T.-H., & Lin, L.-C. (2012). New Alkaloids and Cytotoxic Principles from Sinomenium acutum. Planta Medica, 78(17), 1873-1877. doi:10.1055/s-0032-1327785
  15. Don, M.-J., Lin, L.-C., & Chiou, W.-F. (2012). Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells. Phytomedicine, 19(6), 551-561. doi:10.1016/j.phymed.2012.01.006
  16. Lin, C.-C., Yen, J.-C., Wu, Y.-T., Lin, L.-C., & Tsai, T.-H. (2012). Chemical analysis and transplacental transfer of oseltamivir and oseltamivir carboxylic Acid in pregnant rats. PLoS One, 7(10). doi:10.1371/journal.pone.0046062
  17. Lin, L.-C., Li, S.-H., Wu, Y.-T., Kuo, K.-L., & Tsai, T.-H. (2012). Pharmacokinetics and urine metabolite identification of dehydroevodiamine in the rat. Journal of Agricultural and Food Chemistry, 60(7), 1595-1604. doi:10.1021/jf204365m
  18. Shaw, L.-H., Lin, L.-C., & Tsai, T.-H. (2012). HPLC-MS/MS Analysis of a Traditional Chinese Medical Formulation of Bu-Yang-Huan-Wu-Tang and Its Pharmacokinetics after Oral Administration to Rats. PLoS One, 7(8). doi:10.1371/journal.pone.0043848
  19. Tsai, Y.-M., Wan-Ling, C.-L., Chien, C.-F., Lin, L.-C., & Tsai, T.-H. (2012). Effects of polymer molecular weight on relative oral bioavailability of curcumin. International Journal of Nanomedicine, 7, 2957-2966. doi:10.2147/IJN.S32630
  20. Wan-Ling, C.-L., Chien, C.-F., Lin, L.-C., & Tsai, T.-H. (2012). Isolation of gentiopicroside from Gentianae Radix and its pharmacokinetics on liver ischemia/reperfusion rats. Journal of Ethnopharmacology, 141(2), 668-673. doi:10.1016/j.jep.2011.08.001
  21. Chiou, W.-F., Shen, C.-C., & Lin, L.-C. (2011). Anti-inflammatory principles from Balanophora laxiflora. Journal of Food and Drug Analysis, 19(4), 502-508.
  22. Lin, L.-C., Chiou, C.-T., & Cheng, J.-J. (2011). 5-Deoxyflavones with cytotoxic activity from Mimosa diplotricha. Journal of Natural Products, 74(9), 2001-2004. doi:10.1021/np200307r
  23. Lin, L.-C., Tsai, T.-H., & Su, S.-C. (2011). A novel 8.O.6′-neolignan from Taxillus theifer. Natural Product Research, 25(14), 1319-1323. doi:10.1080/14786419.2010.529443
  24. Tsai, Y.-M., Chien, C.-F., Lin, L.-C., & Tsai, T.-H. (2011). Curcumin and its nano-formulation: The kinetics of tissue distribution and blood–brain barrier penetration. International Journal of Pharmaceutics, 416(1), 331-338. doi:10.1016/j.ijpharm.2011.06.030
  25. Tsai, Y.-M., Jan, W.-C., Chien, C.-F., Lee, W.-C., Lin, L.-C., & Tsai, T.-H. (2011). Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats. Food Chemistry, 127(3), 918-925. doi:10.1016/j.foodchem.2011.01.059
  26. Tsai, T.H., Liu, Y.C., Lin, L.C.* (2010) Flavonoids from Taxillus theifer. J. Food Drug Anal., 18:256–262.
  27. Wu, Y.T., Lin, C.W., Lin, L.C., Chiu, A.W., Chen, K.K., Tsai, T.H. (2010) Analysis of biliary excretion of icariin in rats. J. Agric. Food Chem., 58:9905–9911.
  28. Tsai,Y.J., Lin, L.C., Tsai, T.H. (2010) Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat. J. Agric. Food Chem.,58:4638–4643.
  29. Wu, Y.T., Kao, Y.L., Lin, L.C., Tsai, T.H. (2010) Effects of a P-glycoprotein modulator on the pharmacokinetics and distribution of free levobupivacaine and bupivacaine in rats. Int. J. Pharm., 396:127–133.
  30. Wang, G.J., Tsai, T.H., Chang, T.T., Chou, C.J., and Lin, L.C. (2009) "Lanostanes from Phellinus igniarius and their iNOS inhibitory activities." Planta Med., Vol.75, pp.1-6.
  31. Liu, H.K., Tsai, T.H., Chang, T.T., Chou, C.J., and Lin, L.C.* (2009) "Lanostane-triterpenoids from fungus Phellinus gilvus." Phytochemistry, Vol.70, pp.558-563.
  32. Lin, L.C., Chen, Y.F., Lee, W.C., Wu, Y.T., and Tsai, T.H. (2008) "Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS." J. Pharmaceut. Biomed. Anal., Vol.48, pp.909-917.
  33. Tsai, T.H., and Lin, L.C.* (2008) "Phenolic glycosides and pyrrolidine alkaloids from Codonopsis tangshen." Chem. Pharm. Bull., Vol.56, pp.1546-1550.
  34. Tsai, T.H., Wang, G.J., and Lin, L.C.* (2008) "Vasorelaxing alkaloids and flavonoids from Cassytha filiformis." J. Nat. Prod., Vol.71, pp.289-291.
  35. Lin, L.C., Chen, Y.F., Tsai, T.R., and Tsai, T.H. (2007) "Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat." Anal. Chim. Acta, Vol.590, pp.173-179.
  36. Wang, G.J., Tsai, T.H., and Lin, L.C.* (2007) "Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum." Phytochemistry, Vol.68, pp.2455-2464.
  37. Lin, L.C., Wang, M.N., Tseng, T.Y., Sung, J.S., and Tsai, T.H. (2007) "Pharmacokinetics of (-)-epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distribution." J. Argic. Food Chem., Vol.55, pp.1517-1524.
  38. Lin, L.C.*, Shen, C.C., Shen, Y.C., and Tsai, T.H. (2006) "Anti-inflammatory neolignans"  Piper kadsur. J. Nat. Prod., Vol.69, pp.842-844.
  39. Shyr, M.H., Tsai, T.H., and Lin, L.C.* (2006) "Rossicasins A, B and rosicaside F, three new phenylpropanoid glycosides.” Boschniakia rossica. Chem. Pharm. Bull., Vol.54, pp.252-254.
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