Current position: Associate Research Fellow
E-mail:  lwt0220@nricm.edu.tw
Telephone: 886-2-2820-1999 ext. 8261(office), 8281(lab)

Education: Ph.D., National Tsing Hua University

Specialty
Chinese Medicinal Chemistry, Medicinal Chemistry, Phytochemistry, Organic/organometallic Chemistry

Research Description

Our current research interests involve the Chinese medicinal chemistry, phytochemistry, synthetic organic and medicinal chemistry. Research topics include the development of novel and efficient synthetic methods, design and synthesis of biologically active molecules and synthesis of natural products derived from traditional Chinese medicine.

Publication (2015~)

1. Liang, Y.-E.; Kan, C.-Y.; Barve, B. D.; Chen, Y.-A.; Li, W.-T.* Palladium-catalyzed chemo- and regiocontrolled tandem cyclization/cross-coupling of 2-benzyl-3-alkynyl chromones with aryl iodides for the synthesis of 4H-furo[3,2-c]chromenes and xanthones. Org. Lett. 2022, DOI: 10.1021/acs.orglett.2c02476. (front cover)
2. Liang, Y.-E.; Kan, C.-Y.; Barve, B. D.; Kuo, Y.-H.; Fang, H.-W.; Li, W.-T.* Metal-free, base-promoted, tandem pericyclic reaction: a one-pot approach for cycloheptane-annelated chromones from g-alkynyl-1,3-diketones. Adv. Synth. Catal. 2022, 364, 233-463 DOI: 10.1002/adsc.202100956 (selected as a VIP: Very Important Publication, front cover).
3. Barve, B. D.; Kuo, Y.-H.; Li, W.-T.* Pd-catalyzed and ligand-enabled alkene difunctionalization via unactivated C–H bond functionalization, Chem. Commum. 2021, 57, 12045-12057. DOI: 10.1039/d1cc04397h. (back cover)
4. Liang, Y.-E.; Barve, B.-D.; Kuo, Y.-H.; Fang, H.-W.; Kuo, T.-S.; Li, W.-T.* Metal‐free, DBU‐mediated, microwave‐assisted synthesis of benzo[c]xanthones by tandem reactions of alkynyl‐1,3‐diketones. Adv. Synth. Catal. 2021, 363, 505-511.
5. Chen, C.-C.; Chen, L.-Y.; Li, W.-T.; Chang, K.-L.; Tseng, H.-W.; Chen, B.-Y.; Chen, C.-J.; Hsieh, J.-F. Ultrasound-assisted transglutaminase catalysis of the cross-linking and microstructure of αs-casein, β-casein and κ-casein. Processes 2021, 9, 1630.
6. Wu, T.-H.; Wang, P.-W.; Lin, T.-Y.; Yang, P.-M.; Li, W.-T.; Yeh, C.-T.; Pan, T.-L. Antioxidant properties of red raspberry extract alleviate hepatic fibrosis via inducing apoptosis and transdifferentiation of activated hepatic stellate cells. Biomed. Pharmacother., 2021, 144, 112281.
7. Chen, C.-C.; Chen, L.-Y.; Li, W.-T., Chang, K.-L.; Kuo, M.-I.; Chen, C.-J.; Hsieh, J.-F. Influence of chymosin on physicochemical and hydrolysis characteristics of casein micelles and individual caseins. Nanomaterials 2021, 11, 2594.
8. Li, W.-T., Chuang, Y.-H., Liao, J.-H., Hsieh, J.-F. Synthesis of 2-(4-hydroxyphenyl)ethyl 3,4,5-Trihydroxybenzoate and Its Inhibitory Effect on Sucrase and Maltase. Processes 2020, 8, 1603.
9. Liang, Y.-E.; Lu, C.-L.; Li, W.-T.* Pd-catalyzed sequential hydroarylation and olefination reactions of 3-allylchromones. Org. Biomol. Chem. 2019, 32, 7569-7583.
10. Li, W.-T.; Chuang, Y.-H.; Hsieh, J.-F. Characterization of maltase and sucrase inhibitory constituents from Rhodiola crenulata. Foods 2019, 8, 540.
11. Wang, P.-W.; Cheng, Y.-C.; Hung, Y.-C.; Lee, C.-H.; Fang, J.-Y.; Li, W.-T.; Wu, Y.-R.; Pan, T.-L. Red raspberry extract protects the skin against UVB-induced damage with antioxidative and anti-inflammatory properties. Oxid. Med. Cell Longev. 2019, 2019, 9529676.
12. Lin, Y.-F.; Fong, C.; Peng, W.-L.; Tang, K.-C.; Liang, Y.-E.; Li, W.-T.* Synthesis of 3-(2-olefinbenzyl)-4H-chromen-4-one through cyclobenzylation and catalytic C-H bond functionalization using palladium(II). J. Org. Chem. 2017, 82, 10855-10865.
13. Chen, P.-C.; Tsai, W.-J.; Ueng, Y.-F; Tzeng, T.-T.; Chen, H.-L.; Zhu, P.-R.; Huang, C.-H.; Shiao, Y.-J.*; Li, W.-T.* Neuroprotective and anti-neuroinflammatory effects of hydroxyl-functionalized stilbenes and 2-arylbenzo[b]furans. J. Med. Chem. 2017, 60, 4062-4073.
14. Hsia, S.-Y.; Hsiao, Y.-H.; Li, W.-T.; Hsieh, J.-F.* Aggregation of soy protein-isoflavone complexes and gel formation induced by glucono-δ-lactone in soymilk. Sci. Rep. 2016, 6, 35718.
15. Lin, W.-J.; Shia, K.-S.; Song, J.-S.; Wu, M.-H.; Li, W.-T.* Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions. Org. Biomol. Chem. 2016, 14, 220-28.
16. Wang, P.-W.; Hung, Y.-C.; Li, W.-T.; Yeh, C.-T.; Pan, T.-L. Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics. Oncotarget 2016, 98, 1-12.
17. Ka, S.-M.; Chao, Kuoping; Lin, J.-C.; Chen, S.-T.; Li, W.-T.; Lin, C.-N.; Cheng, J.-C.; Jheng, H.-L.; Chen, A; Hua, K.-F. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med. 2016, 91, 10-24.
18. Chiou, C.-T.; Lee, W.-C.; Liao, J.-H.; Cheng, J.-J.; Lin, L.-C.; Chen, C.-Y.; Song, J.-S.; Wu, M.-H.; Shia, K.-S. Li, W.-T.* Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents. Eur. J. Med. Chem. 2015, 98, 1-12.
19. Hsieh, J.-F.; Lin, W.-J.; Huang, K.-F.; Liao, J.-H.; Don, M.-J.; Shen, C.-C.; Shiao, Y.-J.; Li, W.-T.* Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans. Eur. J. Med. Chem. 2015, 93, 443-451.
20. Hsiao, Y.-H.; Yu, C.-J.; Li, W.-T.; Hsieh, J.-F. Coagulation of β-conglycinin, glycinin and isoflavones induced by calcium chloride in soymilk. Sci. Rep. 2015, 5, 13018-13020.