Current Position：Assistant Research Fellow
Tel：02-2820-1999 ext.6701
E-mail : iwenlo99@nricm.edu.tw

EDUCATION:
BS: Department of Marine Biotechnology and Resources, National Sun Yat-sen University
MS: Department of Marine Biotechnology and Resources, National Sun Yat-sen University
PhD: Department of Pharmacy, National Taiwan University

EXPERIENCE:
Postdoctoral fellow, Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan (2014.09-2016.08)
Postdoctoral fellow, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (2016.09-2017.08)
Postdoctoral fellow, Genomics Research Center, Academia Sinica, Taipei, Taiwan (2018.03-2022.09)

SPECIALTY :

1. Natural Product Chemistry
2. Analytical Chemistry
3. Protein Crystallization

RESEARCH INTEREST:
Our group focuses on the discovery of small molecule natural products and the application of enzymes involved in their biosynthetic pathways, including:

1. Biologically active compounds purification and identification;
2. Natural products chemistry, including biosynthetic pathways of secondary metabolites according to their biosynthetic gene clusters (BGCs) by using bioinformatics analyses, and deduction of enzyme functions and mechanisms;
3. Discover uncharacterized small-molecules/enzymes in microbiomes by combining protein sequence similarity network (SSN) analysis with metagenomics;
4. Computational simulation of small molecule‒protein interactions and mechanistic insight from crystal structure of small molecule‒protein complexes.

CURRENT QUINQUENNIAL PUBLICATIONS:

 NCBI PubMed : Wen-Chiung Chang (Please click!!) 

1. Huang, H.-T.; Lo, I-W.; Lin, Y.-C.; Liao, G.-Y.; Lin, Y.-S.; Zhang, L.-J.; Li, T.-L.; Liaw, C.-C.;* Kuo, Y.-H.* (2023). Kaguacidine A: a novel spirohydantoin-containing cucurbitane glycoside from vines of Momordica charantia L. Natural Product Research, 6, 1-8. (IF: 2.488)
2. Lo, I-W.; Liao, G.-Y.; Lee, J.-C.; Chang, C.-I; Wu, Y.-C.; Liu, S.-P.; Su, H.-J.; Liu, C.-I; Kuo, C.-Y.; Lin, Z.-Y.; Li, T.-L.;* Lin, Y.-S.;* Liaw, C.-C.* (2022). Novel Aporphine- and Proaporphine-Clerodane Hybrids Identified from the Barks of Taiwanese Polyalthia Longifolia var. pendula with Strong Anti-DENV2 Activity. Pharmaceuticals, 15(10), 1218. (IF: 5.215)
3. Huang, H.-T.;† Lo, I-W.;† Liao, G.-Y.; Lin, Y.-C.; Shen, Y.-C.; Huang, H.-C.; Li, T.-L.; Lee, K.-T.; * Kuo, Y.-H.;* Liaw, C.-C.* (2022). “Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley” Frontier in Chemistry, 10, 1003356. †These two authors contributed equally to this work. (IF: 5.545)
4. Wang, Z.-C.;† Lo, I-W.;† Lin, K.-H.; Cheng, A.-N.; Zadeh, S. M.; Huang, Y.-H.; Li, T.-L.* (2022). In vivo and in vitro characterization of halogenation and drug-transportation genes encoded in the albofungin biosynthetic gene cluster. Applied and Environmental Microbiology, 88(17), e0080622. †These two authors contributed equally to this work. (IF: 5.005)
5. Zadeh, S. M.; Chen, M.-H.; Wang, Z.-C.; Astani, E. K.; Lo, I-W.; Lin, K.-H.; Hsu, N.-S.; Adhikari, K.; Lyu, S.-Y.; Tsai, H.-Y.; Terasawa, Y.; Yabe, M.; Yamamoto, K.; Ichikawa, S.; Li, T.-L.* (2022). b-Hydroxylation of α-amino-β-hydroxylbutanoylglycyl-uridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin. Communications Chemistry, 5, 87. (IF: 7.211)
6. Liaw, C.-C.; Lo, I-W.; Lin, Y.-C.; Huang, H.-T.; Zhang, L.-J.; Hsiao, P.-C.; Li, T.-L.;* Kuo, Y.-H.* (2022). Four cucurbitane glycosides taimordisins A–D with novel furopyranone skeletons isolated from the fruits of Momordica charantia. Food Chemistry: X, 14, 100286. (IF: 6.443)
7. Adhikari, K.; Lo, I-W.; Chen, C.-L.; Wang, Y.-L.; Lin, K.-H.; Zadeh, S. M.; Rattinam, R.; Li, Y.-S.; Wu, C.-J.; Li, T.-L.* (2020). Chemoenzymatic Synthesis and Biological Evaluation for Bioactive Molecules Derived from Bacterial Benzoyl Coenzyme A Ligase and Plant Type III Polyketide Synthase. Biomolecules, 10(5), 738. (IF: 6.064)
8. Huang, C.-M.; Lyu, S.-Y.; Lin, K.-H.; Chen, C.-L.; Chen, M.-H.; Shih, H.-W.; Hsu, N.-S.; Lo, I-W.; Wang, Y.-L.; Li, Y.-S.; Wu, C.-J.; Li, T.-L.* (2019). Teicoplanin Reprogrammed with the N-Acyl-Glucosamine Pharmacophore at the Penultimate Residue of Aglycone Acquires Broad-Spectrum Antimicrobial Activities Effectively Killing Gram-Positive and -Negative Pathogens. ACS Infectious Diseases, 5(3), 430-442. (IF: 5.578)