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Associate Research Fellow/Li, Wen-Tai

李文泰大頭照

Current position: Associate Research Fellow
E-mail:  
lwt0220@nricm.edu.tw
Telephone: 886-2-2820-1999 ext. 8261(office), 8281(lab)

 Education: Ph.D., National Tsing Hua University

Major Professional Experiences
Postdoctoral Research Fellow, Institute of Biological Chemistry, Academia Sinica
Postdoctoral Research Fellow, Department of Chemistry, The Ohio State University

 Specialty
Chinese Medicinal Chemistry, Medicinal Chemistry, Phytochemistry, Organic/organometallic Chemistry

 Research Description

Our current research interests involve the Chinese medicinal chemistry, phytochemistry, synthetic organic and medicinal chemistry. Research topics include the development of novel and efficient synthetic methods, design and synthesis of biologically active molecules and synthesis of natural products derived from traditional Chinese medicine.

 Publication (2015~)

NCBI PubMed :  Wen-Tai Li (Please click!!)
  1. Liang, Y.-E.; Kan, C.-Y.; Barve, B. D.; Kuo, Y.-H.; Fang, H.-W.; Li, W.-T.* Metal-free, base-promoted, tandem pericyclic reaction: a one-pot approach for cycloheptane-annelated chromones from g-alkynyl-1,3-diketones. Adv. Synth. Catal. 2021, DOI: 10.1002/adsc.202100956 (VIP, front cover).
  2. Barve, B. D.; Kuo, Y.-H.; Li, W.-T.* Pd-catalyzed and ligand-enabled alkene difunctionalization via unactivated C–H bond functionalization, Chem. Commum. 2021, DOI: 10.1039/d1cc04397h.
  3. Liang, Y.-E.; Barve, B.-D.; Kuo, Y.-H.; Fang, H.-W.; Kuo, T.-S.; Li, W.-T.* Metal‐free, DBU‐mediated, microwave‐assisted synthesis of benzo[c]xanthones by tandem reactions of alkynyl‐1,3‐diketones. Adv. Synth. Catal. 2021, 363, 505-511.
  4. Chen, C.-C.; Chen, L.-Y.; Li, W.-T.; Chang, K.-L.; Tseng, H.-W.; Chen, B.-Y.; Chen, C.-J.; Hsieh, J.-F. Ultrasound-assisted transglutaminase catalysis of the cross-linking and microstructure of αs-casein, β-casein and κ-casein. Processes 2021, 9, 1630.
  5. Wu, T.-H.; Wang, P.-W.; Lin, T.-Y.; Yang, P.-M.; Li, W.-T.; Yeh, C.-T.; Pan, T.-L. Antioxidant properties of red raspberry extract alleviate hepatic fibrosis via inducing apoptosis and transdifferentiation of activated hepatic stellate cells. Biomed. Pharmacother., 2021, 144, 112281.
  6. Chen, C.-C.; Chen, L.-Y.; Li, W.-T., Chang, K.-L.; Kuo, M.-I.; Chen, C.-J.; Hsieh, J.-F. Influence of chymosin on physicochemical and hydrolysis characteristics of casein micelles and individual caseins. Nanomaterials 2021, 11, 2594.
  7. Li, W.-T., Chuang, Y.-H., Liao, J.-H., Hsieh, J.-F. Synthesis of 2-(4-hydroxyphenyl)ethyl 3,4,5-Trihydroxybenzoate and Its Inhibitory Effect on Sucrase and Maltase. Processes 2020, 8, 1603.
  8. Liang, Y.-E.; Lu, C.-L.; Li, W.-T.* Pd-catalyzed sequential hydroarylation and olefination reactions of 3-allylchromones. Org. Biomol. Chem. 2019, 32, 7569-7583.
  9. Li, W.-T.; Chuang, Y.-H.; Hsieh, J.-F. Characterization of maltase and sucrase inhibitory constituents from Rhodiola crenulata. Foods 2019, 8, 540.
  10. Wang, P.-W.; Cheng, Y.-C.; Hung, Y.-C.; Lee, C.-H.; Fang, J.-Y.; Li, W.-T.; Wu, Y.-R.; Pan, T.-L. Red raspberry extract protects the skin against UVB-induced damage with antioxidative and anti-inflammatory properties. Oxid. Med. Cell Longev. 2019, 2019, 9529676.
  11. Lin, Y.-F.; Fong, C.; Peng, W.-L.; Tang, K.-C.; Liang, Y.-E.; Li, W.-T.* Synthesis of 3-(2-olefinbenzyl)-4H-chromen-4-one through cyclobenzylation and catalytic C-H bond functionalization using palladium(II). J. Org. Chem. 2017, 82, 10855-10865.
  12. Chen, P.-C.; Tsai, W.-J.; Ueng, Y.-F; Tzeng, T.-T.; Chen, H.-L.; Zhu, P.-R.; Huang, C.-H.; Shiao, Y.-J.*; Li, W.-T.* Neuroprotective and anti-neuroinflammatory effects of hydroxyl-functionalized stilbenes and 2-arylbenzo[b]furans. J. Med. Chem. 201760, 4062-4073.
  13. Hsia, S.-Y.; Hsiao, Y.-H.; Li, W.-T.; Hsieh, J.-F.* Aggregation of soy protein-isoflavone complexes and gel formation induced by glucono-δ-lactone in soymilk. Sci. Rep. 2016, 6, 35718.
  14. Lin, W.-J.; Shia, K.-S.; Song, J.-S.; Wu, M.-H.; Li, W.-T.* Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions. Org. Biomol. Chem. 2016, 14, 220-28.
  15. Wang, P.-W.; Hung, Y.-C.; Li, W.-T.; Yeh, C.-T.; Pan, T.-L. Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics. Oncotarget 2016, 98, 1-12.
  16. Ka, S.-M.; Chao, Kuoping; Lin, J.-C.; Chen, S.-T.; Li, W.-T.; Lin, C.-N.; Cheng, J.-C.; Jheng, H.-L.; Chen, A; Hua, K.-F. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med. 2016, 91, 10-24.
  17. Chiou, C.-T.; Lee, W.-C.; Liao, J.-H.; Cheng, J.-J.; Lin, L.-C.; Chen, C.-Y.; Song, J.-S.; Wu, M.-H.; Shia, K.-S. Li, W.-T.* Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents. Eur. J. Med. Chem. 2015, 98, 1-12.
  18. Hsieh, J.-F.; Lin, W.-J.; Huang, K.-F.; Liao, J.-H.; Don, M.-J.; Shen, C.-C.; Shiao, Y.-J.; Li, W.-T.* Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans. Eur. J. Med. Chem. 2015, 93, 443-451.
  19. Hsiao, Y.-H.; Yu, C.-J.; Li, W.-T.; Hsieh, J.-F. Coagulation of β-conglycinin, glycinin and isoflavones induced by calcium chloride in soymilk. Sci. Rep. 2015, 5, 13018-13020.
Patent
  1. 李文泰、邱俊棠、鄭靜枝、林麗純,吲哚酮衍生物用於治療癌症之用途,中華民國專利發明第I 541230號 (2016)
  2. 劉慧康、林麗純、李文泰、黃琤、蔡耿彰,具有GLP-1受體調控活性之化合物及其用途,中華民國專利發明第I 511963號(2015)
  3. 蔡耿彰、林雲蓮、李文泰、林麗純、蕭乃文、溫志宏、王惠民、陳朝龍、陳旺全,皮膚美白用化合物及皮膚用組成物,中華民國專利第I 426926號;中國人民共和國專利號 ZL 2013 1 0011308.1 (2014)
 

 
 
 

 

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