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Associate Research Fellow/Lu, Chung-Kuang

盧重光辦公室的生活照Current position:Associate Research Fellow
Telephone:886-2-2820-1999 Ext 5441
Fax:886-2-28264266
E-mailcklu@nricm.edu.tw
 
Education: Ph.D., Institute of Oceanography, National Taiwan University
 
Major Professional Experiences
Assistant Research Fellow, National Museum of Marine Biology & Aquarium
Assistant Professor, Institute of Marine Biotechnology, National Dong Hwa University
Assistant Professor, School Pharmacy, Taipei Medical University
 
Specialty
Natural Product Chemistry, Cultural Techniques of Microbes
 
Research Description
Our research project focuses on developing and applying biotechnology to detect, isolate, identify and evaluate novel biologically active metabolites from the highly diverse microbes. To discover new anticancer,cardiovascular, and reduction in blood sugar agents from microbes is the priority goal. The collections of microbes from special environments are mass-cultured and managed for bioactive detections. Hundreds of extracts from marine dinofalgellates and cyanobacteria show promise as potential antitumor and antidiabetes agents. Target active agents are isolated through bioassay directed fractionation strategies using of modern chromatographic techniques. Structure elucidation is achieved through a combination of advanced spectroscopic analysis, as well as chemical modification.

In addition, the growth condition for production of targeted compounds is investigated through optimizing the nutrients and physical states of the microbes’ culture. Those amounts of the bioactive compounds which are required for further bioactive mechanism and absolute stereochemistry studies will be provided by the continuous cultures. The development of total technology for cultivation of microbes will assist with the development of commercial-scale microbe’s culturing techniques for the reproducible production of bioactive compounds.
 
Published Papers
NCBI PubMed :  Chung-Kuang Lu (Please click!!)
  1. Yu, C.-H., Lu, C.-K., Su, H.-M., Chiang, T.-Y., Hwang, C.-C., Liu, T., & Chen, Y.-M. (2015). Draft genome of Myxosarcina sp. strain GI1, a baeocytous cyanobacterium associated with the marine sponge Terpios hoshinota. Standards in Genomic Sciences, 10:28. doi:10.1186/s40793-015-0011-3
  2. Shen, Y.-C., Lu, C.-K., Liou, K.-T., Hou, Y.-C., Lin, Y.-L., Wang, Y.-H., . . . Wang, H.-W. (2015). Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses. Journal of Ethnopharmacology. doi:10.1016/j.jep.2015.07.018.
  3. Hou, Y.-C., Lu, C.-K., Wang, Y.-H., Chern, C.-M., Liou, K.-T., Wang, H.-W., & Shen, Y.-C. (2013). Unique mechanisms of sheng yu decoction (聖愈湯 Shèng Yù Tang) on ischemic stroke mice revealed by an integrated neurofunctional and transcriptome analysis. Journal of Traditional and Complementary Medicine, 3(4), 240-249. doi:10.4103/2225-4110.119703
  4. More, S. V., Chang, T.-T., Chiao, Y.-P., Jao, S.-C., Lu, C.-K., & Li, W.-S. (2013). Glycosylation enhances the anti-migratory activities of isomalyngamide A analogs. European Journal of Medicinal Chemistry, 64, 169-178. doi:10.1016/j.ejmech.2013.03.044
  5. Chen, H.-J., Shen, Y.-C., Lin, C.-Y., Tsai, K.-C., Lu, C.-K., Shen, C.-C., & Lin, Y.-L. (2012). Metabolomics study of Buyang Huanwu Tang Decoction in ischemic stroke mice by 1H NMR. Metabolomics, 8(5), 974-984. doi:10.1007/s11306-011-0394-0
  6. Chen, T.-Y., Lin, H.-Y., Lin, C.-C., Lu, C.-K., & Chen, Y.-M. (2012). Picochlorum as an alternative to Nannochloropsis for grouper larval rearing. Aquaculture, 338-341, 82-88. doi:10.1016/j.aquaculture.2012.01.011
  7. Chang, T. T., Shivaji, V. M., Lu, I. H., Hsu, J.-C., Chen, T.-J., Jen, Y. C., . . . Li, W.-S. (2011). Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro. European Journal of Medicinal Chemistry, 46(9), 3810-3819. doi:10.1016/j.ejmech.2011.05.049
  8. Lee, T.-H., Lu, C.-K., Wang, G.-J., Chang, Y.-C., Yang, W.-B., & Ju, Y.-M. (2011). Sesquiterpene glycosides from Cosmospora joca. Journal of Natural Products, 74(7), 1561-1567. doi:10.1021/np200056e
  9. Lin, Y.-L., Lu, C.-K., Huang, Y.-J., & Chen, H.-J. (2011). Antioxidative caffeoylquinic acids and flavonoids from Hemerocallis fulva flowers. Journal of Agricultural and Food Chemistry, 59(16), 8789-8795. doi:10.1021/jf201166b
  10. Lu, C.-K., Wang, S.-K., & Duh, C.-Y. (2011). New pregnane steroids from Formosan red alga Ceratodictyon spongiosum and symbiotic sponge Sigmadocia symbiotica. Bulletin of the Chemical Society of Japan, 84(9), 943-946. doi:10.1246/bcsj.20110100
  11. Wang, H.-W., Liou, K.-T., Wang, Y.-H., Lu, C.-K., Lin, Y.-L., Lee, I. J., . . . Shen, Y.-C. (2011). Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. Journal of Ethnopharmacology, 138(1), 22-33. doi:10.1016/j.jep.2011.06.033
  12. Chung-Kuang Lu*, Yi-Min Chen, Siang-Hang Wang, 2010, Prorocentin-4,a novel linear polyketide from a marine dinoflagellate Prorocentrum sp.Tetrahedron Letters 51, 6911-6914.
  13. Huey-Lang Yang, Chung-Kuang Lu, Shu-Fen Chen, Young-Mao Chen, Yi-Min Chen*, 2010, Isolation and Characterization of Taiwanese Heterotrophic Microalgae: Screening of Strains for Docosahexaenoic Acid (DHA) Production.Marine Biotechnology 12, 173–185.
  14. Huang, S.J., Kuo, C.M., Lin, Y.C., Chen, Y.M., and Lu, C.K.* (2009) Carteraol E, a potent polyhydroxyl  ichthyotoxin from the dinoflagellate Amphidinium carterae. Tetrahedron Lett., 50, 2512-2515.
  15. Lu, C.K.*, Chen, Y.M., Wang, S.H., Wu, Y.Y., and Cheng, Y.M. (2009) Formosalides A and B, cytotoxic 17-membered ring macrolides from a marine dinofalgellate Prorocentrum sp. Tetrahedron Lett., 50,1825-1827.
  16. Lee, T.H., Lu, C.K., Kuo, Y.H., Lo, J.M., and Lee, C.K.* (2008) Unexpected novel pheophytin peroxides from the leaves of Biden pilosa. Helv. Chim. Acta, 91, 79-84.
  17. Chao, C.H., Huang, H.C., Wu, Y.C., Lu, C.K., Dai, C.F., and Sheu, J.H.* (2007) Glycolipids from the formosan soft coral Lobophytum crassum. Chem. Pharm. Bull., 55, 1720-1723.
  18. Chen, S.P., Chao, C.H., Huang, H.C., Wu, Y.C., Lu, C.K., Dai, C.F., and Sheu, J.H.* (2006) New β-caryophyllene-derived terpenoids from the formosan soft coral Sinularia gibberosa. Bull. Chem. Soc. Jap.,79, 1547-1551.
  19. Chao, C.H., Hsieh, C.H., Chen, S.P., Lu, C.K., Dai, C.F., and Sheu, J.H.* (2006) Sinularianins A and B, novel sesquiterpenoids from the formosan soft coral Sinularia sp. Tetrahedron Lett., 47, 5889-5891.
  20. Chen, S.P., Ahmed, A.F., Dai, C.F., Lu, C.K., Hu, W.P., Wang, J.J., and Sheu, J.H.* (2006) Sinugiberosides A-E, new terpenoids with cyclic peroxyhemiketal from the soft coral Sinularia gibberosa. Tetrahedron, 62,6802-6807.
  21. Chao, C.H., Hsieh, C.H., Chen, S.P., Lu, C.K., Dai, C.F., Wu, Y.C., and Sheu, J.H.* (2006) Novel cyclic sesquiterpene peroxides from the formosan soft coral Sinularia sp. Tetrahedron Lett., 47, 2175-2178.
  22. Su, J.H., Tseng, Y.J., Huang, H.H., Ahmed, A.F., Lu, C.K., Wu, Y.C., and Sheu, J.H.* (2006) 9, 11-Secosterols from the soft corals Sinularia lochmodes and Sinularia leptoclados. J. Nat. Prod., 69,850-852.
  23. Lu, C.K.*, Chou, H.N., Lee, C.K., and Lee, T.H. (2005) Prorocentin, a new polyketide from the marine dinoflagellate Prorocentrum lima. Org. Lett., 7, 3893-3896.
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