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李文泰 (Li, Wen-Tai)

姓名: 李文泰 (Li, Wen-Tai)李文泰大頭照
職稱: 副研究員
電話:
02-2820-1999 8261(辦公室)8281(實驗室)
E-mail: lwt0220@nricm.edu.tw

學歷:
清華大學 化學系 博士

主要經歷:
中央研究院 博士後研究 
美國俄亥俄卅立大學 博士後研究
衛生福利部國家中醫藥研究所 助理研究員

專長:
中藥化學、藥物化學、藥物設計與合成

研究簡介:
   
我們的研究興趣主要著重於中藥化學及藥物設計與合成,並藉由開發新的合成策略,合成具有潛力的新藥物,研究主題包括:
(1) 發展新的合成方法合成具有生物活性的中草藥化合物及其衍生物
(2) 中草藥成分分析與研究
(3) 探討中草藥化合物及其衍生物的藥理作用機制

期刊論文:
       
期刊 (2015~)

  1. Liang, Y.-E.; Kan, C.-Y.; Barve, B. D.; Kuo, Y.-H.; Fang, H.-W.; Li, W.-T.* Metal-free, base-promoted, tandem pericyclic reaction: a one-pot approach for cycloheptane-annelated chromones from g-alkynyl-1,3-diketones. Adv. Synth. Catal. 2021, DOI: 10.1002/adsc.202100956 (VIP, front cover).
  2. Barve, B. D.; Kuo, Y.-H.; Li, W.-T.* Pd-catalyzed and ligand-enabled alkene difunctionalization via unactivated C–H bond functionalization, Chem. Commum. 2021, DOI: 10.1039/d1cc04397h.
  3. Liang, Y.-E.; Barve, B.-D.; Kuo, Y.-H.; Fang, H.-W.; Kuo, T.-S.; Li, W.-T.* Metal‐free, DBU‐mediated, microwave‐assisted synthesis of benzo[c]xanthones by tandem reactions of alkynyl‐1,3‐diketones. Adv. Synth. Catal. 2021, 363, 505-511.
  4. Chen, C.-C.; Chen, L.-Y.; Li, W.-T.; Chang, K.-L.; Tseng, H.-W.; Chen, B.-Y.; Chen, C.-J.; Hsieh, J.-F. Ultrasound-assisted transglutaminase catalysis of the cross-linking and microstructure of αs-casein, β-casein and κ-casein. Processes 2021, 9, 1630.
  5. Wu, T.-H.; Wang, P.-W.; Lin, T.-Y.; Yang, P.-M.; Li, W.-T.; Yeh, C.-T.; Pan, T.-L. Antioxidant properties of red raspberry extract alleviate hepatic fibrosis via inducing apoptosis and transdifferentiation of activated hepatic stellate cells. Biomed. Pharmacother., 2021, 144, 112281.
  6. Chen, C.-C.; Chen, L.-Y.; Li, W.-T., Chang, K.-L.; Kuo, M.-I.; Chen, C.-J.; Hsieh, J.-F. Influence of chymosin on physicochemical and hydrolysis characteristics of casein micelles and individual caseins. Nanomaterials 2021, 11, 2594.
  7. Li, W.-T., Chuang, Y.-H., Liao, J.-H., Hsieh, J.-F. Synthesis of 2-(4-hydroxyphenyl)ethyl 3,4,5-Trihydroxybenzoate and Its Inhibitory Effect on Sucrase and Maltase. Processes 2020, 8, 1603.
  8. Liang, Y.-E.; Lu, C.-L.; Li, W.-T.* Pd-catalyzed sequential hydroarylation and olefination reactions of 3-allylchromones. Org. Biomol. Chem. 2019, 32, 7569-7583.
  9. Li, W.-T.; Chuang, Y.-H.; Hsieh, J.-F. Characterization of maltase and sucrase inhibitory constituents from Rhodiola crenulata. Foods 2019, 8, 540.
  10. Wang, P.-W.; Cheng, Y.-C.; Hung, Y.-C.; Lee, C.-H.; Fang, J.-Y.; Li, W.-T.; Wu, Y.-R.; Pan, T.-L. Red raspberry extract protects the skin against UVB-induced damage with antioxidative and anti-inflammatory properties. Oxid. Med. Cell Longev. 2019, 2019, 9529676.
  11. Lin, Y.-F.; Fong, C.; Peng, W.-L.; Tang, K.-C.; Liang, Y.-E.; Li, W.-T.* Synthesis of 3-(2-olefinbenzyl)-4H-chromen-4-one through cyclobenzylation and catalytic C-H bond functionalization using palladium(II). J. Org. Chem. 2017, 82, 10855-10865.
  12. Chen, P.-C.; Tsai, W.-J.; Ueng, Y.-F; Tzeng, T.-T.; Chen, H.-L.; Zhu, P.-R.; Huang, C.-H.; Shiao, Y.-J.*; Li, W.-T.* Neuroprotective and anti-neuroinflammatory effects of hydroxyl-functionalized stilbenes and 2-arylbenzo[b]furans. J. Med. Chem. 201760, 4062-4073.
  13. Hsia, S.-Y.; Hsiao, Y.-H.; Li, W.-T.; Hsieh, J.-F.* Aggregation of soy protein-isoflavone complexes and gel formation induced by glucono-δ-lactone in soymilk. Sci. Rep. 2016, 6, 35718.
  14. Lin, W.-J.; Shia, K.-S.; Song, J.-S.; Wu, M.-H.; Li, W.-T.* Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions. Org. Biomol. Chem. 2016, 14, 220-28.
  15. Wang, P.-W.; Hung, Y.-C.; Li, W.-T.; Yeh, C.-T.; Pan, T.-L. Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics. Oncotarget 2016, 98, 1-12.
  16. Ka, S.-M.; Chao, Kuoping; Lin, J.-C.; Chen, S.-T.; Li, W.-T.; Lin, C.-N.; Cheng, J.-C.; Jheng, H.-L.; Chen, A; Hua, K.-F. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med. 2016, 91, 10-24.
  17. Chiou, C.-T.; Lee, W.-C.; Liao, J.-H.; Cheng, J.-J.; Lin, L.-C.; Chen, C.-Y.; Song, J.-S.; Wu, M.-H.; Shia, K.-S. Li, W.-T.* Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents. Eur. J. Med. Chem. 2015, 98, 1-12.
  18. Hsieh, J.-F.; Lin, W.-J.; Huang, K.-F.; Liao, J.-H.; Don, M.-J.; Shen, C.-C.; Shiao, Y.-J.; Li, W.-T.* Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans. Eur. J. Med. Chem. 2015, 93, 443-451.
  19. Hsiao, Y.-H.; Yu, C.-J.; Li, W.-T.; Hsieh, J.-F. Coagulation of β-conglycinin, glycinin and isoflavones induced by calcium chloride in soymilk. Sci. Rep. 2015, 5, 13018-13020.
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