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鄭靜枝(Cheng, Jing-Jy)

鄭靜枝個人生活照姓名:鄭靜枝(Cheng, Jing-Jy)
職稱:副研究員
電話: 2820-19993671、3691
E-mail : verona@nricm.edu.tw

學歷:
國防醫學院 生命科學研究所 博士 1993-1998
中國醫藥大學 中國藥學研究所 碩士 1991-1993
中國醫藥大學 藥學系 學士 1987-1991

主要經歷:
中央研究院 生物醫學科學研究所 博士後研究員
國立陽明大學 生醫光電所 兼任助理教授

專長:
血管新生,癌症,內皮細胞活性,細胞訊息傳遞,細胞生物學

研究簡介:
      本實驗室的研究方向主要是探討中草藥對於血管內皮細胞的保護機制,藉由體外發炎模式、血管新生作用模式及癌症動物模式的建立,以篩選具有潛力的中草藥或天然物,並詳細探討細胞訊息傳遞之分子機轉及活性探討,俾能對中草藥之研究及推廣有所助益,進而應用在新藥之研發上。同時實驗室負責人於2008年起管理癌症治療藥物核心實驗室之職至今。

目前建立的研究領域包括:

一、血管保護作用:藉由血管內皮細胞之體外模式,探討動脈硬化過程中與免疫反應相關之發炎過程,以適當的標的基因來篩選預防動脈粥狀硬化之藥物,並探討其分子機轉。
二、血管新生抑制劑開發:利用Matrigel之體外模式評估血管新生作用,以篩選血管新生抑制劑藥物並探討其分子機轉,並進一步以動物進行生物體的確效,以應用於癌症之治療。
三、癌症治療劑或輔助藥劑開發:已建立癌症細胞毒殺平台及肺癌動物模式,並進一步以標靶治療的方向進行天然物或合成修飾物的癌症藥物開發,並探討相關訊息傳遞及細胞週期變化。

期刊論文:所內研究人員(用Email)點選編輯點此編輯

      NCBI PubMed :  Jing-Jy Cheng (Please click!!)

  1. Mar, A.-C., Chu, C.-H., Lee, H.-J., Chien, C.-W., Cheng, J.-J., Yang, S.-H., . . . Lee, T.-C. (2015). Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of IL-6 and VEGF-A in Colon Cancer Cells and Induce Angiogenesis. The Journal of Biological Chemistry. doi:10.1074/jbc.M115.644823
  2. Solum, E. J., Cheng, J.-J., Sørvik, I. B., Paulsen, R. E., Vik, A., & Hansen, T. V. (2014). Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis. European Journal of Medicinal Chemistry, 85, 391-398. doi:10.1016/j.ejmech.2014.08.002
  3. Cheng, J. J. (2012). Caffeic Acid Phenethyl Ester Suppresses IFN-γ-Induced STAT1 Activation and Gene Expression in Endothelial Cells. Journal of Chinese Medicine, 23(2), 103-112.
  4. Cheng, J.-J., Tsai, T.-H., & Lin, L.-C. (2012). New Alkaloids and Cytotoxic Principles from Sinomenium acutum. Planta Medica, 78(17), 1873-1877. doi:10.1055/s-0032-1327785
  5. Øyvind, W. A., Odlo, K., Cheng, J.-J., Maccari, G., Botta, M., & Hansen, T. V. (2012). Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1. Bioorganic & Medicinal Chemistry, 20(1), 234-242. doi:10.1016/j.bmc.2011.11.010
  6. Shen, C.-C., Cheng, J.-J., Lay, H.-L., Wu, S.-Y., Ni, C.-L., Chen, C.-C., & Teng, C.-M. (2012). Cytotoxic apigenin derivatives from Chrysopogon aciculatis. Journal of Natural Products, 75(2), 198-201. doi:10.1021/np2007796
  7. Zhang, L.-J., Cheng, J.-J., Liao, C.-C., Cheng, H.-L., Huang, H.-T., Kuo, L.-M. Y., & Kuo, Y.-H. (2012). Triterpene Acids from Euscaphis japonica and Assessment of Their Cytotoxic and Anti-NO Activities. Planta Medica, 78(14), 1584-1590. doi:10.1055/s-0032-1315040
  8. Cheng, J.-J., Lu, M.-K., Lin, C.-Y., & Chang, C.-C. (2011). Characterization and functional elucidation of a fucosylated 1,6-α-D-mannogalactan polysaccharide from Antrodia cinnamomea. Carbohydrate Polymers, 83(2), 545-553. doi:10.1016/j.carbpol.2010.08.016
  9. Lin, L.-C., Chiou, C.-T., & Cheng, J.-J. (2011). 5-Deoxyflavones with cytotoxic activity from Mimosa diplotricha. Journal of Natural Products, 74(9), 2001-2004. doi:10.1021/np200307r
  10. Chen, S.C., Lin, Y.L., Lin, S.J., Wang, D.L., Cheng, J.J.* (2011) Salvianolic acid B suppresses IFN-γ-induced JAK/STAT1 activation in endothelial cells. Thromb. Res., 128:560–564.
  11. Lu, M.K.*, Cheng, J.J.*, Lin, C.Y., Chang, C.C. (2010) Purification, structural elucidation, and anti-inflammatory effect of a water-soluble 1,6-branched 1,3-α-d-galactan from cultured mycelia of Poria cocos. Food Chem., 118:349–356. (* equal contribution)
  12. Cheng, J.J., Zhang, L.J., Cheng, H.L., Kuo, Y.H. (2010) Cytotoxic hexacyclic triterpene acids from Euscaphis japonica. J. Nat. Prod., 73:1655–1658.
  13. Lu, M.K.#, Cheng, J.J.#, Lin, C.Y., and Chang, C.C. (2010) Purification, structural elucidation, and antiinflammatory effect of a water-soluble 1,6-branched 1,3-α-d-galactan from cultured mycelia of Poria cocos. Food Chem., 118, 349-356. (# equal contribution)
  14. Cheng, J.J., Huang, N.K., Lur, H.S., Kuo, C.I., Lu, M.K. (2009) Characterization and biological functions of sulfated polysaccharides from sulfated-salt treatment of Antrodia cinnamomea. Process Biochem., 44:453–459.
  15. Cheng, J.J., Lur, H.S., Huang, N.K., Chen, H.P., Lin, C.Y., Lu, M.K. (2009) Exploring the potential of biopharmaceutical production by Rigidoporus ulmarius: cultivation, chemistry, and bioactivity studies. Process Biochem., 44:1237–1244.
  16. Cheng, J.J., Lin, C.Y., Lur, H.S., Chen, H.P., Lu, M.K. (2008) Properties and biological functions of polysaccharides and ethanolic extracts isolated from medicinal fungus, Fomitopsis pinicola. Process Biochem., 43:829–834.
  17. Cheng, J.J., Lin, C.Y., Lur, H.S., Chen, H.P., and Lu, M.K. (2008) Production, characterization and functions of polysaccharides and ethanolic extract isolated from medicinal fungus Fomitopsis pinicola. Process Biochem., 43, 829-834.
  18. Lu, M.K., Cheng, J.J., Lai, W.L., Lin, Y.R., and Huang, N.K. (2008) Fermented Antrodia cinnamomea extract prevents rat PC12 cells from serum deprivation-induced apoptosis. J. Agri. Food Chem., 56, 865-874.
  19. Lee, M.S., Cheng, J.J., Lin, C.Y., Chen, Y.J., and Lu, M.K.* (2007) Precursor feeding strategy for the production of solanine, solanidine and solasodine by a cell culture of Solanum lyratum. Process Biochem., 42, 899-903.
  20. Chen, S.C., Chang, Y.L., Wang, D.L., Cheng, J.J.* (2006) Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells. Br. J. Pharmacol., 148:226–232.
  21. Lu, M.K., Cheng, J.J.#, Lai, W.L., Lin, Y.R., and Huang, N.K. (2006) Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A2A receptors. Life Sci., 79, 252-258. (# Equally contribute)
  22. Chen, S.C., Lu, M.K., Cheng, J.J., and Wang, D.L. (2005) Antiangiogenic activities of polysaccharides isolated from medical fungi. FEMS Microbiol. Lett., 249, 247-254.
  23. Cheng, J.J., Huang, N.K., Chang, T.T., Wang, D.L., and Lu, M.K. (2005) Study for anti-angiogenic activities of polysaccharides isolated from Antrodia camphorata in endothelial cells. Life Sci., 76, 3029-3042.
  24. Cheng, J.J., Yang, C.J., Cheng, C.H., Wang, Y.T., Huang, N.K., and Lu, M.K. (2005) Characterization and functional study of Antrodia camphorata lipopolysaccharide. J. Agri. Food Chem., 53, 469-474.
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