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黃乃瑰 (Huang, Nai-Kuei)

黃乃瑰博士姓名:黃乃瑰 (Huang, Nai-Kuei)
職稱:研究員
電話 :2820-1999 轉8051,8061
E-mail : andrew@nricm.edu.tw
學歷: 國防醫學院 生命科學研究所 博士
主要經歷 : 中研院生醫所 博士後研究
專長: 神經科學,訊息傳遞,藥物濫用

研究簡介:
  本實驗室主要在研究與篩選中草藥對抗神經退化性疾病之有效成份並探討其保護機轉為何。中草藥為我國固有之文化資產,在傳統或另類醫學裏佔有相當重要的地位;而今,中草藥無論對於臨床醫學、基礎研究、及生物科技等事業而言皆是一全新且極具開發潛力之領域。
  另一方面 ,近年來中樞神經退化性疾病,如巴金森氏 症、漢丁頓氏症或是藥物濫用所引發的神經傷害等,有增加的趨勢,然而相關有效之治療藥物卻附之闕如。因此本實驗室希望從中草藥篩選並萃取出有效的成份用以治療相關之神經退化性疾病。所以目前實驗室已建立如巴金森氏症、漢丁頓氏症、缺血/缺氧、及濫用性藥物所引發之神經毒性的各式細胞膜型作為篩選之用。

期刊論文:
      NCBI PubMed :  Nai-Kuei Huang (Please click!!)
  1. Ji, H.-X., Chang, W.-S., Tsai, C.-W., Wang, J.-Y., Huang, N.-K., Lee, A.-S., . . . Bau, D. A. T. (2015). Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotype to Gastric Cancer Risk in Taiwan. Anticancer Research, 35(9), 4975-4981.
  2. Huang, C.-L., Lee, Y.-C., Yang, Y.-C., Kuo, T.-Y., & Huang, N.-K. (2012). Minocycline prevents paraquat-induced cell death through attenuating endoplasmic reticulum stress and mitochondrial dysfunction. Toxicology Letters, 209(3), 203-210. doi:10.1016/j.toxlet.2011.12.021
  3. Kuo, T.-Y., Huang, C.-L., Yang, J.-M., Huang, W.-J., Huang, N.-K., Chen, Y.-W., . . . Yang, Y.-C. (2012). The role of ribosylated-BSA in regulating PC12 cell viability. Cell Biology and Toxicology, 28(4), 255-267. doi:10.1007/s10565-012-9220-3
  4. Lee, Y.-C., Yang, Y.-C., Huang, C.-L., Kuo, T.-Y., Lin, J.-H., Yang, D.-M., & Huang, N.-K. (2012). When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders? PLoS One, 7(6). doi:10.1371/journal.pone.0038865
  5. Chen, J.-B., Liu, E. M., Chern, T.-R., Yang, C.-W., Lin, C.-I., Huang, N.-K., . . . Fang, J.-M. (2011). Design and synthesis of novel dual-action compounds targeting the adenosine A2A receptor and adenosine transporter for neuroprotection. ChemMedChem, 6(8), 1390-1400. doi:10.1002/cmdc.201100126
  6. Huang, C.-L., Yang, J.-M., Wang, K.-C., Lee, Y.-C., Lin, Y.-L., Yang, Y.-C., & Huang, N.-K. (2011). Gastrodia elata prevents huntingtin aggregations through activation of the adenosine A2A receptor and ubiquitin proteasome system. Journal of Ethnopharmacology, 138(1), 162-168. doi:10.1016/j.jep.2011.08.075
  7. Huang, N.-K., Lin, J.-H., Lin, J.-T., Lin, C.-I., Liu, E. M., Lin, C.-J., . . . Chern, Y. (2011). A new drug design targeting the adenosinergic system for Huntington's disease. PLoS One, 6(6). doi:10.1371/journal.pone.0020934
  8. Pao, P. C., Huang, N. K., Liu, Y. W., Yeh, S. H., Lin, S. T., Hsieh, C. P., . . . Lee, Y. C. (2011). A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells. Cell Death & Differentiation, 18, 1791-1804. doi:10.1038/cdd.2011.52
  9. Tsai, C.-F., Huang, C.-L., Lin, Y.-L., Lee, Y.-C., Yang, Y.-C., & Huang, N.-K. (2011). The neuroprotective effects of an extract of Gastrodia elata. Journal of Ethnopharmacology, 138(1), 119-125. doi:10.1016/j.jep.2011.08.064
  10. Chin, L.T., Huang, P.R., Hu, K.Y., Huang, N.K., Chiu, C.D., Hour, A.L., Shui, H.A., Chu, C.H., Chen, H.M. (2010) Proteomics-based translational approach reveals an antifolate resistance inherent in human plasma derived from blood donation. J. Proteome Res., 9:3091–3102.
  11. Chen, T.K., Huang, C.L., Lee, Y.C., Liao, W.C., Huang, N.K.* (2010) The roles of the thioredoxin system and peroxiredoxins in 1-methyl-4-phenyl-pyridinium ion-induced cytotoxicity in rat pheochromocytoma cells. Toxicol. In Vitro, 24:1577–1583.
  12. Chen, P., Jou, Y.S., Fann, C.S., Chen, J.W., Chung, C.M., Lin, C.Y., Wu, S.Y., Kang, M.J., Chen, Y.C., Jong, Y.S., Lo, H.M., Kang, C.S., Chen, C.C., Chang, H.C., Huang, N.K., Wu, Y.L., and Pan, W.H. (2009) Lipoprotein lipase variants associated with an endophenotype of hypertension: hypertension combined with elevated triglycerides. Hum. Mutat., 30, 49-55.
  13. Lin, Y.L., Wang, G.J., Huang, C.L., Lee, Y.C., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2009) Ligusticum chuanxiong as a potential neuroprotectant for preventing serum deprivation-induced apoptosis in rat pheochromocytoma cells: functional roles of mitogen-activated protein kinases. J. Ethnopharmacol., 122, 417-423.
  14. Lin, Y.L., Huang, C.L., Lee, Y.C., Liao, W.C., Lai, W.L., Lin, Y.J., and Huang, N.K.* (2009) Mechanisms of Panax ginseng in preventing rat pheochromocytoma cells from apoptosis. J. Ethnopharmacol., 125, 10-15.
  15. Chern, Y., Lin, Y.L., and Huang, N.K. (2008/04) Therapeutic Gastrodia extracts (US 3272869).
  16. Lu, M.K., Cheng, J.J., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2008) Fermented Antrodia cinnamomea extract prevents rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family. J. Agri. Food Chem., 56, 865-874.
  17. Lin, Y.L., Lee, Y.C., Huang, C.L., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2007) Ligusticum chuanxiong prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis through a protein kinase A-dependent pathway. J. Ethnopharmacol., 109, 428-434.
  18. Huang, C.L., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2007) Methamphetamine downregulates the expressions of peroxiredoxins in rat pheochromocytoma cells. Biochem. Biophys. Res. Commun., 354,96-101.
  19. Huang, N.K., Chern, Y., Fang, J.M., Lin, C.I., Chen, W.P., and Lin, Y.L. (2007) Neuroprotective principles from Gastrodia elata. J. Nat. Prod., 70, 571-574.
  20. Lu, M.K., Cheng, J.J., Lai, W.L., Lin, Y.R., and Huang, N.K.* (2006) Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A2A receptors. Life Sci., 79, 252-258.
  21. Huang, N.K., Cheng, J.J., Lai, W.L., and Lu, M.K. (2005) Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis. FEMS Microbiol. Lett., 244, 213-219.
 
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