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董明兆(Don, Ming-Jaw)

董明兆實驗室生活照姓名: 董明兆(Don, Ming-Jaw) 
職稱: 研究員兼中藥化學研究組組長 
電話: 2820-1999轉8411 、8401
E-mail : mjdon@nricm.edu.tw
學歷:
美國北德州大學 化學系 博士
主要經歷:
國立中國醫藥研究所 副研究員
國立中國醫藥研究所 客座副研究員
美國北德州大學 化學系 博士後研究員
專長:
有機化學,藥物化學,天然物化學
研究簡介:
  我的研究興趣在藥物化學及天然物化學領域,研究主題包括中藥材中成份之分離與純化、成份結構之確認、分析方法之建立、中草藥中具活性之天然物合成研究、以及抗癌藥物設計與合成研究並進行結構與活性相關性之探討。這些研究會需要用到許多光譜技術包括1D 與 2D 核磁共振光譜、紅外線光譜以及液相層析質譜分析術。
  本研究室的長期目標為找尋與開發有潛力之抗癌新藥物,希望能對未來治癒癌症有所幫助。
期刊論文:
      NCBI PubMed :  Ming-Jaw Don (Please click!!)
  1. Don, M.-J., Lin, L.-C., & Chiou, W.-F. (2012). Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells. Phytomedicine, 19(6), 551-561. doi:10.1016/j.phymed.2012.01.006
  2. Shen, M.-Y., Liu, Y.-J., Don, M.-J., Liu, H.-Y., Chen, Z.-W., Mettling, C., . . . Yang, W.-C. (2012). Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica. PLoS ONE, 6(11). doi:10.1371/journal.pone.0027480
  3. Chen, T.-H., Yu, H.-J., Lai, T.-C., Chiou, W.-F., & Don, M.-J. (2011). Synthesis and anti-inflammatory effect of four rutaecarpine metabolites. Journal of Chinese Medicine, 22, 37-46.
  4. Chiou, W.-F., Don, M.-J., Liao, J.-F., & Wei, B.-L. (2011). Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways. European Journal of Pharmacology, 650(1), 102-109. doi:10.1016/j.ejphar.2010.10.004
  5. Sun, C.M., Lin, L.G., Yu, H.J., Cheng, C.Y., Tsai, Y.C., Chu, C.W., Din, Y.H., Chau, Y.P., and Don, M.J.*(2007) Synthesis and cytotoxic activities of 4,5-Diarylisoxazoles. Bioorg. Med. Chem. Lett., 17, 1078-1081.
  6. Don, M.J., Liao, J.F., Lin, L.Y., and Chiou, W.F.* (2007) Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of PI3K signaling pathway. Br. J. Pharm., 151, 638-646.
  7. Don, M.J., Ko, H.C., Yang, C.W., and Lin, Y.L.* (2006) Detection of polyphenols and tanshinones in commercial danshen by liquid chromatography with UV and mass spectrometry. J. Food Drug Anal., 14,254-259.
  8. Don, M.J., Shen, C.C., Syu, W.J., Ding, Y.H., and Sun, C.M.* (2006) Cytotoxic and aromatic constituents from Salvia miltiorrhiza. Phytochemistry, 67, 497-503.
  9. Sun, C.M., Chin, T.M., Lin, Y.L., Chen, C.J., Chen, W.C., Wu, T.S., and Don, M.J.* (2006) Isolation, structure elucidation, and syntheses of isoneocryptotanshinone II and tanshinlactone A from Salvia miltiorrhiza. Heterocycles, 68, 247-255.
  10. Don, M.J., Shen, C.C., Lin, Y.L., Syu, W.J., Ding, Y.H., and Sun, C.M.* (2005) Nitrogen-containing compounds from Salvia miltiorrhiza. J. Nat. Prod., 68, 1066-1070.
  11. Ueng, Y.F., Yu, H.J., Lee, C.H., Peng, C., Jan, W.C., Ho, L.K., Chen, C.F., and Don, M.J.* (2005) Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa. J. Chromatogr. A, 1076, 103-109.
  12. Chiou, W.F., Shen, C.C., Yu, H.J., Chiang, C.H., Chen, C.C., Chang, W., and Don, M.J.* (2005) Total synthesis and antioxidative activity of magnolamide from Magnolia coco. Heterocycles, 65, 1215-1220.
  13. Lee, Y.T., Don, M.J., Hung, P.S., Shen, Y.C., Lo, Y.S., Chang, K.W., Chen, C.F., and Ho, L.K.* (2005) Cytotoxicity of phenolic acid phenethyl esters on oral cancer cells. Cancer Lett., 223, 19-25.
  14. Lee, Y.T., Don, M.J., Liao, C.H., Chiou, H.W., Chen, C.F., and Ho, L.K.* (2005) Effects of phenolic acid esters and amides on stimulus-induced reactive oxygen species production in human neutrophils. Clin. Chim. Acta, 352, 135-141.
  15. Lin, C.N., Syu, W.J., Sun, W.S., Chen, J.W., Chen, T.H., Don, M.J.*, Wang, S.H.* (2010) A role of ygfZ in the Escherichia coli response to plumbagin challenge. J. Biomed. Sci., 17:84.
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