2019 研究論文
Novel efficient bioprocessing of marine chitins into active anticancer prodigiosin
Nguyen VB, Chen SP, Nguyen TH, Nguyen MT, Tran TTT, Doan CT, Tran TN, Nguyen AD, Kuo YH, Wang SL.
Mar Drugs. 2019;18(1):15. doi: 10.3390/md18010015.
Bioactive constituents of Lindernia crustacea and its anti-EBV effect via Rta expression inhibition in the viral lytic cycle
Tsai YC, Hohmann J, El-Shazly M, Chang LK, Dankó B, Kúsz N, Hsieh CT, Hunyadi A, Chang FR.
J Ethnopharmacol. 2020;250:112493. doi: 10.1016/j.jep.2019.112493. Epub 2019 Dec 18.
Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons
Wu PC, Fann MJ, Tran TT, Chen SC, Devina T, Cheng IH, Lien CC, Kao LS, Wang SJ, Fuh JL, Tzeng TT, Huang CY, Shiao YJ, Wong YH.
Sci Rep. 2019;9(1):19301. doi: 10.1038/s41598-019-55614-9.
Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice
Chang TC, Chiang H, Lai YH, Huang YL, Huang HC, Liang YC, Liu HK, Huang C.
BMC Complement Altern Med. 2019;19(1):368. doi: 10.1186/s12906-019-2782-3.
Less cytotoxic protoflavones as antiviral agents: Protoapigenone 1'-O-isopropyl ether shows improved selectivity against the Epstein-Barr virus lytic cycle
Vágvölgyi M, Girst G, Kúsz N, Ötvös SB, Fülöp F, Hohmann J, Servais JY, Seguin-Devaux C, Chang FR, Chen MS, Chang LK, Hunyadi A.
Int J Mol Sci. 2019;20(24):6269. doi: 10.3390/ijms20246269.
Cytotoxicity assessment of PM2.5 collected from specific anthropogenic activities in Taiwan
Ngo TH, Tsai PC, Ueng YF, Chi KH.
Int J Environ Res Public Health. 2019;16(24):5043. doi: 10.3390/ijerph16245043.

黃信麒 、 蔡忠志 、 蘇奕彰


Osthole ameliorates cartilage degradation by downregulation of NF-κB and HIF-2α pathways in an osteoarthritis murine model
Chern CM, Zhou H, Wang YH, Chang CL, Chiou WF, Chang WT, Yao CH, Liou KT, Shen YC.
Eur J Pharmacol. 2020;867:172799. doi: 10.1016/j.ejphar.2019.172799. Epub 2019 Nov 22.
Effect of tracheal intubation mode on cuff pressure during retractor splay and dysphonia recovery after for anterior cervical spine surgery: A randomized clinical trial
Huang WC, Tan EC, Chang CC, Kuo YH, Hsu XTJ, Chang WK, Huang SS, Chen PT, Chu YC.
Spine (Phila Pa 1976). 2020;45(9):565-572. doi: 10.1097/BRS.0000000000003339.
Characterization of maltase and sucrase inhibitory constituents from Rhodiola crenulata
Li WT, Chuang YH, Hsieh JF.
Foods. 2019;8(11):540. doi: 10.3390/foods8110540.
Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3
Cheng CF, Ku HC, Cheng JJ, Chao SW, Li HF, Lai PF, Chang CC, Don MJ, Chen HH, Lin H.
Commun Biol. 2019;2:389. doi: 10.1038/s42003-019-0624-y. eCollection 2019.
Diterpenoids and bisnorditerpenoids from Blumea aromatica
Shen CC, Wei WCLin LC.
J Nat Prod. 2019;82(11):3181-3185. doi: 10.1021/acs.jnatprod.9b00674. 
New indications of potential rat intestinal α-glucosidase inhibition by Syzygium zeylanicum (L.) and its hypoglycemic effect in mice
Nguyen VB, Wang SL, Nguyen TH, Doan CT, Tran TN, Kuo YH, Nguyen QV, Nguyen A.D.
Res Chem Intermed 2019;45:6061-6071. doi: 10.1007/s11164-019-04019-4
Anti-lymphangiogenic alkaloids from the zoanthid Zoanthus vietnamensis collected in Taiwan
Chen SR, Wang SW, Chang FR, Cheng YB.
J Nat Prod. 2019;82(10):2790-2799. doi: 10.1021/acs.jnatprod.9b00451.
Bringing scientific methods to traditional medicine
Tseng YHChang FR.
J Formos Med Assoc. 2019;118(12):1574-1575. doi: 10.1016/j.jfma.2019.08.022. 
Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis
Huang HT, Lin YC, Zhang LJ, Liaw CC, Chen HY, Hsueh MT, Kuo YH.
Nat Prod Res. 2019:1-8. doi: 10.1080/14786419.2019.1666383. Online ahead of print.
A thrice-weekly ertapenem regimen is practical for hemodialysis patients
Ueng YF, Wang HJ, Wu SC, Ng YY.
Antimicrob Agents Chemother. 2019;63(12):e01427-19. doi: 10.1128/AAC.01427-19. Online ahead of print.
Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet-induced metabolic dysfunction and nonalcoholic fatty liver disease in mice
Chiang H, Lee JC, Huang HC, Huang H, Liu HK, Huang C.
Br J Pharmacol. 2020;177(2):239-253. doi: 10.1111/bph.14859. Epub 2019 Nov 12.
Development of a tool for assessing quality of comprehensive care provided by community health workers in a community-based care programme in South Africa
Griffiths F, Babalola O, Brown C, de Kadt J, Malatji H, Thorogood M, Tseng YH, Goudge J.
BMJ Open. 2019;9(9):e030677. doi: 10.1136/bmjopen-2019-030677.
Marine natural products: A source of novel anticancer drugs
SM, Musharraf SG, Chang FR, Iwasaki A, Suenaga K, Alajlani M, Göransson U, El-Seedi HR.
Mar Drugs. 2019;17(9):491. doi: 10.3390/md17090491.




Development and validation of nomograms for predicting survival probability of patients with advanced adenocarcinoma in different EGFR mutation status
Chen HC, Tan EC, Liao CH, Lin ZZ, Yang MC.
PLoS One. 2019;14(8):e0220730. doi: 10.1371/journal.pone.0220730. eCollection 2019.
Pd-Catalyzed sequential hydroarylation and olefination reactions of 3-allylchromones
Liang YE, Lu CL, Li WT.
Org Biomol Chem. 2019;17:7569-7583. doi: 10.1039/C9OB01147A.
Sodium thiosulfate enhances production of polysaccharides and anticancer activities of sulfated polysaccharides in Antrodia cinnamomea
Lin TY, Chang CC, Tseng AJ, Chao CH, Lu MK.
Carbohydr Polym. 2019;216:204-212. doi: 10.1016/j.carbpol.2019.04.017.
Simply mixing poly protein G with detection antibodies enhances the detection limit and sensitivity of immunoassays
Chen YJ, Chen M, Cheng TL, Roffler SR, Lin SY, Hsu HL, Wang CH, Chen CY, Kao AP, Cheng JJ, Chuang KH.
Anal Chem. 2019;91(13):8310-8317. doi: 10.1021/acs.analchem.9b01077.
Ergostatrien-7,9(11),22-trien-3β-ol from Antrodia camphorata ameliorates ischemic stroke brain injury via downregulation of p65NF-κ-B and caspase 3, and activation of Akt/GSK3/catenin-associated neurogenesis
Wang YH , Chern CM , Liou KT , Kuo YH , Shen YC.
Food Funct. 2019;10(8):4725-4738. doi: 10.1039/c9fo00908f.
Proton pump inhibitor use and risk of hepatocellular carcinoma reply
Kao WY, Tan EC, Su CW.
Hepatology.2019;70(1):440-441. doi: 10.1002/hep.30632.
Isolated compounds from Turpinia formosana Nakai induce ossification
Imtiyaz Z, Wang YF, Lin YT, Liu HK, Lee MH.
Int J Mol Sci. 2019;20(13):3119. doi: 10.3390/ijms20133119.
2-Iodo-4'-methoxychalcone attenuates methylglyoxal-induced neurotoxicity by activation of GLP-1 receptor and enhancement of neurotrophic signal, antioxidant defense and glyoxalase pathway
Tseng YT, Tsai YH, Fülöp F, Chang FR, Lo YC.
Molecules. 2019;24(12):2249. doi: 10.3390/molecules24122249.
Plasma endoxifen and 4-hydroxytamoxifen levels in CYP2D6(C100T) carrying breast cancer patients and association with serum cholesterol
Chao TC, Pan WC, Tsai YF, Chou YC, Liu YR, Wang SF, Chen YJ, Souček P, Ueng YF.
Toxicol Appl Pharmacol. 2019;378:114619. doi: 10.1016/j.taap.2019.114619.
Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations
Huang NK, Lin CC, Lin YL, Huang CL, Chiou CT, Lee YC, Lee SY, Huang HT, Yang YC.
Phytomedicine. 2019;59:152756. doi: 10.1016/j.phymed.2018.11.016. Epub 2018 Nov 14.
Neuroprotective effects of Crataegus pinnatifida extracts on paraquat-induced PC12 cell death
Shen YC, Kuo YH, Juan CW, Chang CL, Lin PK, Wang JH, Chen HS.
Biocell. 2019;43(2):22-28.
Protective effects of selenium on wheat seedlings under salt stress
Lan CY, Lin KH, Huang WD, Chen CC.
Agronomy(Basel). 2019;9(6):272. doi: 10.3390/agronomy9060272.
Bioprocessing shrimp shells for rat intestinal α-glucosidase inhibitor and its effect on reducing blood glucose in a mouse model
Nguyen VB, Nguyen TH, Nguyen AD, Le T, Kuo YH, Wang SL.
Res Chem Intermed. 2019;45:4829-4846. doi: 10.1007/s11164-019-03869-2.
Physiological effects of the fungicide azoxystrobin on wheat seedlings under extreme heat
Lan CY, Lin KH, Huang WD, Chen CC.
Not Bot Horti Agrobo. 2019;47(3):683-690. doi: 10.15835/nbha47311448.

Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1
Lin LC, Lee LC, Huang C, Chen CT, Song JS, Shiao YJLiu HK.

Phytomedicine. 2019;62:152946. doi: 10.1016/j.phymed.2019.152946.

Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents
Yang CY, Li HY, Sung FC, Tan EC, Wei JN, Chuang LM. 
Diabet Med. 2019;36(5):633-643. doi: 10.1111/dme.13925.
A sulfated glucan from Antrodia cinnamomea reduces Slug expression through regulation of TGFβ/AKT/GSK3β axis in lung cancer
Lin TY, Tseng AJ, Qiu WL, Chao CH, Lu MK.
Carbohydr Polym. 2019;210:175-184. doi: 10.1016/j.carbpol.2019.01.078.
New dammarane-type saponins from Gynostemma pentaphyllum
Chen PY, Chang CC, Huang HC, Zhang LJ, Liaw CC, Lin YC, Nguyen NL, Vo TH, Cheng YY, Morris-Natschke SL, Lee KH, Kuo YH.
Molecules. 2019;24(7):1375. doi: 10.3390/molecules24071375.
Executive summary of the DAROC clinical practice guidelines for diabetes care- 2018
Diabetes Association Of The Republic Of China Taiwan.(Tan EC)
J Formos Med Assoc. 2020;119(2):577-586. doi: 10.1016/j.jfma.2019.02.016. Epub 2019 Apr 3.
Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
Su H, Liu KT, Chen BH, Lin YP, Jiang YM, Tsai YH, Chang FR, Shiea J, Lee CW.
J Food Drug Anal. 2019;27(2):415-427. doi: 10.1016/j.jfda.2018.11.001.
Synthesis and anti‐inflammatory effect of morachalcone B, morachalcone C, and analogs
Jhong BS, Lin TY, Kao CH, Yu HJ, Chin TM, Liu CY, Shen YC, Don MJ.
J Chin Chem Soc. 2019;66(4):409-414. doi: 10.1002/jccs.201800261.
Ampelopsin A and ampelopsin C induce apoptosis and metastasis through down-regulating AxL, TYRO3, and FYN expressions in MDA-MB-231 breast cancer cells
Huang C, Huang YL, Wang CC, Pan YL, Lai YH, Huang HC.
J Agric Food Chem. 2019;67(10):2818-2830. doi: 10.1021/acs.jafc.8b06444.
Chemical constituents of the plant Antidesma ghaesembilla
Gonzales RL, Shen CC, Lee IJ, Don MJ, Ragasa CY.
Chem Nat Compd. 2019;55(2):382-385. doi: 10.1007/s10600-019-02698-4.
Exploring the mode of action of inhibitors targeting the PhoP response regulator of Salmonella enterica through comprehensive pharmacophore approaches
Tsai KC, Hung PP, Cheng CF, Chen CP, Tseng TS.
RSC Adv. 2019;9:9308-9312. doi: 10.1039/C9RA00620F.
Integrating community health workers into the formal health system to improve performance: a qualitative study on the role of on-site supervision in the South African programme
Tseng YH, Griffiths F, de Kadt J, Nxumalo N, Rwafa T, Malatji H, Goudge J.
BMJ Open. 2019;9(2):e022186. doi: 10.1136/bmjopen-2018-022186.
Anti-inflammatory effect of afatinib (an EGFR-TKI) on OGD-induced neuroinflammation
Chen YJ, Hsu CC, Shiao YJ, Wang HT, Lo YL, Lin AMY.
Sci Rep. 2019;9(1):2516. doi: 10.1038/s41598-019-38676-7.
Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex
Kuo CJ, Huang CC, Chou SY, Lo YC, Kao TJ, Huang NK, Lin C, Lin HC, Lin HC, Lee YC.
Phytomedicine. 2019;54:132-139. doi: 10.1016/j.phymed.2018.09.203. Epub 2018 Sep 20.
Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma
Kant R, Yen CH, Hung JH, Lu CK, Tung CY, Chang PC, Chen YH, Tyan YC, Chen YA.
Sci Rep. 2019 Feb 13;9(1):1968. doi: 10.1038/s41598-018-37292-1.
Different effects of 4β-hydroxywithanolide E and withaferin A, two withanolides from Solanaceae plants, on the Akt signaling pathway in human breast cancer cells
Wang HC, Hu HH, Chang FR, Tsai JY, Kuo CY, Wu YC, Wu CC.
Phytomedicine. 2019;53:213-222. doi: 10.1016/j.phymed.2018.09.017. Epub 2018 Sep 5.
Protective effects of Liuwei dihuang water extracts on diabetic muscle atrophy
Tseng YT, Chang WH, Lin CC, Chang FR, Wu PC, Lo YC.
Phytomedicine. 2019;53:96-106. doi: 10.1016/j.phymed.2018.09.032. Epub 2018 Sep 5.
Chicken-derived humanized antibody targeting a novel epitope F2pep of fibroblast growth factor receptor 2: potential cancer therapeutic agent
Tsai KC, Chang CD, Cheng MH, Lin TY, Lo YN, Yang TW, Chang FL, Chiang CW, Lee YC, Yen Y.
ACS Omega. 2019;4(1):2387-2397. doi: 10.1021/acsomega.8b03072.
Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells
Huang WC, Gu PY, Fang LW, Huang YL, Lin CF, Liou CJ.
Phytomedicine. 2019;61:152852. doi: 10.1016/j.phymed.2019.152852. 
Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation
Chen PJ, Ko IL, Lee CL, Hu HC, Chang FR, Wu YC, Leu YL, Wu CC, Lin CY, Pan CY, Tsai YF, Hwang TL.
EBioMedicine. 2019;40:528-540. doi: 10.1016/j.ebiom.2019.01.043. 
Combined proteomic and metabolomic analyses of cerebrospinal fluid from mice with ischemic stroke reveals the effects of a Buyang Huanwu decoction in neurodegenerative disease
Hsu WH, Shen YC, Shiao YJ, Kuo CH, Lu CK, Lin TY, Ku WC, Lin YL.
PLoS One. 2019;14(1):e0209184. doi: 10.1371/journal.pone.0209184. eCollection 2019.
Red raspberry extract protects the skin against UVB-induced damage with antioxidative and anti-inflammatory properties
Wang PW, Cheng YC, Hung YC, Lee CH, Fang JY, Li WT, Wu YR, Pan TL.
Oxid Med Cell Longev. 2019;2019:9529676. doi: 10.1155/2019/9529676. eCollection 2019.

The use of time-domain analysis on the choice of measurement location for pulse diagnosis research: A pilot study
Tsai YN, Chang YH, Huang YC, Jui-Shan Lin S, Lee SM, Cheng YY, Su YC.
J Chin Med Assoc. 2019;82(1):78-85. doi: 10.1016/j.jcma.2018.07.002.