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Chang CC, Yuan W, Lin YL, Liu RS, Juan YC, Sun WH, Tsay HJ, Huang HC, Lee YC, Liu, H.-K.(2016) Evaluation of the in vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays. Evid Based Complement Alternat Med. 2016;2016:3262790. doi: 10.1155/2016/3262790.
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Chang CC, Yuan W, Roan HY, Chang JL, Huang HC, Lee YC, Tsay HJ, Liu, H.-K.(2016) The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity. BMC Complement Altern Med. 2016 Nov 3;16(1):432.
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Huang HC, Lee CP, Liu, H.-K., Chang MF, Lai YH, Lee YC, Huang C.(2016) Cellular Nuclear Export Factors TAP and Aly Are Required for HDAg-L-mediated Assembly of Hepatitis Delta Virus. J Biol Chem. 2016 Dec 9;291(50):26226-26238.
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Liu, H.-K., Hung TM, Huang HC, Lee IJ, Chang CC, Cheng JJ, Lin LC, Huang C.(2015). Bai-Hu-Jia-Ren-Shen-Tang Decoction Reduces Fatty Liver by Activating AMP-Activated Protein Kinase In Vitro and In Vivo. Evid Based Complement Alternat Med. 2015;2015:651734. doi: 10.1155/2015/651734.
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Shie, F.-S., Shiao, Y.-J., Yeh, C.-W., Lin, C.-H., Tzeng, T.-T., Hsu, H.-C., . . . Liu, H.-K. (2015). Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice. PLoS One,10(8). doi:10.1371/journal.pone.0134531
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Yeh, C.-W., Yeh, S. H.-H., Shie, F.-S., Lai, W.-S., Liu, H.-K. Tzeng, T.-T., . . . Shiao, Y.-J. (2015). Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice. Neurobiology of Aging.doi:10.1016/j.neurobiolaging.2015.07.022
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Juan, Y.-C., Chang, C.-C., Tsai, W.-J., Lin, Y.-L., Hsu, Y.-S., & Liu, H.-K. (2011). Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix. Journal of Ethnopharmacology, 137(1), 592-600. doi:10.1016/j.jep.2011.06.007
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Juan, Y.-C., Kuo, Y.-H., Chang, C.-C., Zhang, L.-J., Lin, Y.-Y., Hsu, C.-Y., & Liu, H.-K. (2011). Administration of a decoction of sucrose- and polysaccharide-rich Radix Astragali (Huang Qi) ameliorated insulin resistance and fatty liver but affected beta-cell function in type 2 diabetic rats. Evidence-Based Complementary and Alternative Medicine. doi:10.1093/ecam/nep238
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Lin, M.-H., Liu, H.-K., Huang, W.-J., Huang, C.-C., Wu, T.-H., & Hsu, F.-L. (2011). Evaluation of the potential hypoglycemic and beta-cell protective constituents isolated from Corni Fructus to tackle insulin-dependent diabetes mellitus. Journal of Agricultural and Food Chemistry, 59(14), 7743-7751. doi:10.1021/jf201189r
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Zhang, L.-J., Liu, H.-K., Hsiao, P.-C., Kuo, Y.-L.-M., Lee, I. J., Wu, T.-S., . . . Kuo, Y.-H. (2011). New isoflavonoid glycosides and related constituents from Astragali Radix (Astragalus membranaceus) and their inhibitory activity on nitric oxide production. Journal of Agricultural and Food Chemistry, 59(4), 1131-1137. doi:10.1021/jf103610j
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Liu, H-K. Studies of Toxin Resistant Beta-Cells: Lessons for the Chemotherapy? Cell Respiration and Cell Survival. (Ed) Osterhoudt, G and Barhydt, J. 2010. Nova Science publishers, Inc.
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Juan, Y-C, Tsai, W-J, Lin, Y-L, Wang, G-J, Cheng, J-J, Yang, H-Y, Hsu, C-Y, Liu, H-K*. The novel anti-hyperglycemic effect of Paeoniae Radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK). Phytomedicine. 2010. Jul;17(8-9):626-34. [SCI]
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Liu, H-K, Tsai, T-H, Chang, T-T, Chou, C-J and Lin, I-C*Lanostane-triterpenoids from the fungus Phellinus gilvus. Phytochemistry. 2009.70(4):558-63. [SCI]
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Chen C-C, Hsu C-Y, Chen C-Y, and Liu H-K*. Fructus Corni suppresses hepatic gluconeogenesis related gene transcription,enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death. Journal of Ethnopharmacology. 117(3):483-90, 2008. [SCI]
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Liu HK*, McCluskey JT, McClenghan NH, and Flatt PR. Iterative exposure of clonal BRIN-BD11 cells to ninhydrin enables selection of robust toxin-resistant cells but with decreased gene expression of insulin-secretory function.Pancreas. 36(3):294-301, 2008. [SCI]
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Liu, H-K., Lipina, S.Perrier, C., Finlay D., McLauchlan H., Hastie C.J., Hundal H.S., and Sutherland C.Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3. BMC Molecular Biology, 7:14, 2006. [SCI]
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Liu, H-K., Green, B.D., Flatt, P.R., McClenaghan, N.H. and McCluskey, J.T.Deleterious effects of dehydroepiandrosterone sulphate and dexamethasone on rat insulin-secreting cells under in vitro culture condition. Bioscience Reports,26(1):31-38, 2006. [SCI]
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Ruiz-Alcaraz, A.J., Liu, H.K., Cuthbertson, D.J., McManus, E.J., Ahktar, S.,Lipina, C., Petrie, J.R., Hundal, H.S., and Sutherland, C.A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration. Biochemical Journal, 392(Pt 2): 345-352, 2005. [SCI]
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Green, B.D., Lui, H.K., McCluskey, J.T., Duffy, N.A., O’Harte, F.P.M.,McClenaghan, N.H. and Flatt, P.R.Function of long-term GLP-1 treated pancreatic beta cells is improved by preventing DPP IV mediated degradation of GLP-1. Diabetes, Obesity & Metabolism.7:563-569; 2005. [SCI]
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Liu, H-K., Green, B.D., Flatt, P.R., McClenaghan, N.H. and McCluskey, J.T. Effects of long-term exposure to nicotinamide and sodium butyrate on growth,viability and the function of clonal insulin-secreting cells. Endocrine Research. 30:61-68; 2004. [SCI]
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Liu, H-K., Green, B.D., Gault, V.A., McCluskey, J.T., McClenaghan, N.H.,O'Harte, F.P.M. and Flatt, P.R.N-acetyl-GLP-1: a DPP IV resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell associated gene expression. Cell Biology International. 28: 69-73; 2004. [SCI]
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Liu, H-K., Green, B.D., McClenaghan, N.H., McCluskey, J.T. and Flatt, P.R.Long-term beneficial effects of vanadate, tungstate and molybdate on insulin secretion and function of cultured beta cells. Pancreas, 28: 364-368; 2004. [SCI]