跳到主要內容區
 
:::

董明兆(Don, Ming-Jaw)

董明兆實驗室生活照姓名: 董明兆(Don, Ming-Jaw) 
職稱: 研究員兼中藥化學研究組組長 
電話: 2820-1999轉8411 、8401
E-mail : mjdon@nricm.edu.tw
學歷:
美國北德州大學 化學系 博士
主要經歷:
國立中國醫藥研究所 副研究員
國立中國醫藥研究所 客座副研究員
美國北德州大學 化學系 博士後研究員
專長:
有機化學,藥物化學,天然物化學
研究簡介:
  我的研究興趣在藥物化學及天然物化學領域,研究主題包括中藥材中成份之分離與純化、成份結構之確認、分析方法之建立、中草藥中具活性之天然物合成研究、以及抗癌藥物設計與合成研究並進行結構與活性相關性之探討。這些研究會需要用到許多光譜技術包括1D 與 2D 核磁共振光譜、紅外線光譜以及液相層析質譜分析術。
  本研究室的長期目標為找尋與開發有潛力之抗癌新藥物,希望能對未來治癒癌症有所幫助。
      NCBI PubMed :  Ming-Jaw Don (Please click!!)
  1. Cheng-Tin Lin, Yao-Hung Yang, Jing-Jy Cheng, Ming-Jaw Don*, 2023, Total Syntheses, Absolute Configurations and Cytotoxicity Evaluation of Ugonstilbenes A, B, and C from the Rhizomes of Helminthostachys zeylanica. J. Nat. Prod. 86 (2), 307–316. 
  2. Ting-Yu Lin, Chieh-Yu Chou, Yu-Hsuan Chen, Chien-Kuo Ku, Ming-Jaw Don*, 2022, Total Synthesis of Naturally Occurring Moracinflavan E and Related Compounds. Phytochemistry Lett. 50, 118–127. (SCI) August 2022 
  3. Pei-Yu Wu, Shin-Yu Lai, Yi-Ting Su, Kai-Chien Yang, Yat-Pang Chau, Ming-Jaw Don, Kai-Hsi Lu, Horng-Tzer Shy, Shu-Mei Lai, Hsiu-Ni Kung*, 2022, β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function. Phytomedicine 104, 154255. (SCI) 
  4. Sheng-Yi Lin, Jhih-Pu Syu, Yu-Ting Lo, Yat-Pang Chau, Ming-Jaw Don, Shu-Mei Lai, Hsiu-Ni Kung*, 2022, Mitochondrial activity is the key to the protective effect of β-Lapachone, a NAD+ booster, in healthy cells against cisplatin cytotoxicity. Phytomedicine 101, 154094. (SCI) 
  5. Yueh-Lin Wu, Heng Lin, Hsiao-Fen Li, Ming-Jaw Don, Pei-Chih King, Hsi-Hsien Chen*, 2022, Salvia miltiorrhiza Extract and Individual Synthesized Component Derivatives Induce Activating-Transcription-Factor-3-Mediated Anti-Obesity Effects and Attenuate Obesity-Induced Metabolic Disorder by Suppressing C/EBPα in High-Fat-Induced Obese Mice. Cells 11(6), 1022. (SCI) https://doi.org/10.3390/cells11061022   
  6. Min-Che Tung, Keng-Chang Tsai, Kit-Man Fung, Ming-Jaw Don, Tien-Sheng Tseng, 2021. Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase. RSC Adv. 11(4), 2453-2461. (SCI) (2021 Jan. 6) 
  7. Ragasa, C. Y.*; Si, M.; Tan, M. C. S.; Pelobello, D. H.; Don, M. J.; Shen, C.-C, 2020. A new sesquiterpene from Dendranthema grandiflora flowers. Chemistry of Natural Compounds 56, 436-439. (SCI)
  8. Ching-Feng Cheng, Hui-Chen Ku, Jing-Jy Cheng, Shi-Wei Chao, Hsiao-Fen Li, Pei-Fang Lai, Che-Chang Chang, Ming-Jaw Don, Hsi-Hsien Chen, Heng Lin*, 2019, Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3. Communications Biology 2(1), 1–8. (SCI) DOI 10.1038/s42003-019-0624-y
  9. Bo-Syuan Jhong, Ting-Yu Lin, Chien-Hsiang Kao, Hsi-Jung Yu, Tsung-Mei Chin, Ching-Yang Liu, Yuh-Chiang Shen, Ming-Jaw Don*, 2019, Synthesis and Anti-inflammatory Effect of Morachalcone B, Morachalcone C, and Analogues. J. Chin. Chem. Soc. 66(4), 409–414. (SCI) (April., 2019)
  10. Rhanney L. Gonzales, Chien-Chang Shen, I-Jung Lee, Ming-Jaw Don, Consolacion Y. Ragasa, 2019, Chemical Constitutes of the Plant Antidesma ghaesembilla. Chem. Nat. Compd. 55(2), 382–385. (SCI) (March, 2019)
  11. Jung-Feng Hsieh, Wei-Jen Lin, Kai-Fa Huang, Jiahn-Haur Liao, Ming-Jaw Don, Chien-Chang Shen, Young-Ji Shiao, Wen-Tai Li*, 2015, Antioxidant activity and inhibition of a-glucosidase by hydroxylfunctionalized 2-arylbenzo[b]furans. European Journal of Medicinal Chemistry 93, 443–451. (SCI)
  12. Yu-Ting Tai, Yi-Ling Lin, Chia-Chen Chang, Yih-Giun Cherng, Ming-Jaw Don, Ruei-Ming Chen, 2015, Ring-oxidative biotransformation and drug interactions of propofol in the livers of rats. BioMed Research International 2015:658928. (SCI) doi:10.1155/2015/658928.
瀏覽數: