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Lin, S. Y., Hsieh, S. Y., Fan, Y. T., Wei, W. C., Hsiao, P. W., Tsai, D. H., Wu, T. S.*, and Yang, N. S.* (2017) Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance. Autophagy (Accepted)。
中文說明:紫草又名紫藐具有活血清熱之功效,本篇研究發現自中藥紫草萃取之紫草素,可以誘導腫瘤細胞產生自吞現象及DAMP的表現進而提高抗腫瘤免疫反應。
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Wei, W. C., Lin, S. Y., Lan, C. W., Chen, Y. R., Yang, W. C., and Yang, N. S.* (2016) Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis. Scientific Reports 6, Article number: 36663. doi:10.1038/srep36663. (SCI)
中文說明:大花咸豐草為台灣青草茶主要成分之一,具有降血糖的功效。本篇研究發現大花咸豐草萃取物可有效抑制顆粒性骨髓衍生抑制細胞的分化,進而顯著降低老鼠乳腺腫瘤轉移率及提高手術後老鼠的存活率。
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Lin, T. J., Liang, W. M., Hsiao, P. W., M. S. P, Wei, W. C., Lin, H. T., Yin SY, and Yang, N. S.* (2016) Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine. PLoS One, doi:10.1371/journal. pone.0138335. (SCI)
中文說明:本篇動物實驗研究發現樹突狀細胞為基礎之疫苗,可以改善臨床常使用之免疫抑制劑Rapamycin所促進之腫瘤轉移。
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Wei, W. C., Yang, W. C., Shyur, L. F., Sheu, J. H., Chen, S. S., and Yang, N. S.* (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced IL-12 expression in human dendritic cells. The Journal of Leukocyte Biology 97, 1071-1080. (SCI)
中文說明:本篇研究發現樹突狀細胞IL-12細胞激素新穎調控機制,有助於免疫反應之了解。自大花咸豐草分離之植物化合物cytopiloyne可藉由mTORC2訊息傳導路徑來調控樹突狀細胞IL-12細胞激素的表現。
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Chang, W. T., Lai, T. H., Chyan, Y. J., Yin, S. Y., Chen, Y. H., Wei, W. C., and Yang, N.S.* (2015) Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis. PLoS One, doi: 10.1371/journal.pone.0122374. eCollection 2015. (SCI)
中文說明:自中藥黃耆及黨參萃取之多醣體可以有效提高樹突狀細胞疫苗抗老鼠乳腺腫瘤轉移的活性。
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Chang, F. Y., Hsu, F. J., Tai, C. J., Wei, W. C., Yang, N. S., and Sheu, J. H.* (2014) Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle. Marine Drugs 22, 3060-3071. (SCI)
中文說明:自台灣周邊海域產之軟珊瑚發現eunicellin形式之雙萜類化合物Klymollins T-X。
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Wei, W. C., Wang, J. H., Aravindaram, K., Wang, S. J., Hsu, C. J. Li, Wen, C. C. Sheu, J. H., and Yang, N. S.* (2014) Polysaccharides from Dioscorea and other phytochemicals enhance anti-tumor effects induced by DNA vaccine against melanoma. Journal of Traditional and Complementary Medicine 4, 42-48.
中文說明:中藥典籍記載山藥具有補中益氣之功效,本篇研究顯示山藥多醣體及其他植物化合物可以提高DNA疫苗抗黑色素瘤之活性。
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Wei, W. C., Sung, P. J., Duh, C. Y., Chen, B. W., Sheu, J. H.,* and Yang, N. S.* (2013) Anti-inflammatory activities of natural products isolated from soft corals of Taiwan between 2008 and 2012. Marine Drugs 11, 4083-4126. (SCI)
中文說明:本篇研究將台灣具抗發炎活性之海洋天然物進行系統性地分類比較。
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Yin, S. Y., Wei, W. C., Jian, F. Y., and Yang, N.S. (2013) Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Alternat Med 302426. doi: 10.1155/2013/302426. (SCI)
中文說明:本篇研究回顧草藥對癌症病患之治療應用。
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Chang, W. T., Chen, H. M., Yin, S. Y., Chen, Y. H., Wen, C. C., Wei, W. C., Lai, P., Wang, C. H., and Yang, N. S. (2013) Specific dioscorea phytoextracts enhance potency of TCL-loaded DC-based cancer vaccines. Evid Based Complement Alternat Med 932040. doi: 10.1155/2013/932040. (SCI)
中文說明:本篇研究顯示山藥多醣體可以提高樹突狀細胞疫苗抗老鼠乳腺腫瘤轉移之活性。
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Arulselvan, P., Wen, C. C., Lan, C. W., Chen, Y. H., Wei, W. C., and Yang, N. S.* (2012) Dietary administration of scallion extract effectively inhibits colorectal tumor growth: Cellular and molecular mechanisms. PLoS One 7, e44658. doi:10.1371/journal.pone.0044658. (SCI)
中文說明:本篇研究顯示口服青蔥萃取物可以有效抑制大腸癌生長,本篇研究並進一步提出其細胞及分子抗腫瘤生長之作用機轉。
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Wei, W. C., Lin, S. Y., Chen, Y. J. Wen, C. C., Huang, C. Y., Arulselvan, P., Sheu, J. H.,* and Yang, N. S.* (2011) Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin. Journal of Biomedical Science 18, 94 doi:10.1186/1423-0127-18-94. (SCI)
中文說明:本篇研究顯示海洋briarane形式之雙萜類化合物可以有效抑制TPA誘發之老鼠皮膚炎之產生。
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Wei, W. C., Su, Y. H., Chen, S. S., Sheu, J. H., and Yang, N. S.* (2011) GM-CSF plays a key role in zymosan-stimulated human dendritic cells for activation of Th1 and Th17 cells. Cytokine 55, 79-89. (SCI)
中文說明:本篇研究顯示細胞激素GM-CSF在酵母菌多醣體刺激樹突狀細胞之Th1及Th17免疫反應活化上扮演一重要角色。
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Wen, C. C., Chen, H. M., Chen, S. S., Huang, L. T., Chang, W. T., Wei, W. C., Chou, L. C., Arulselvan, P., Wu, J. B., Kuo, S. C.,* and Yang, N. S.* (2011) Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines. Journal of Biomedical Science 18, 44 doi: 10.1186/1423-0127-18-44. (SCI)
中文說明:特殊去微管聚合試劑增強樹突狀細胞抗癌疫苗之活性。
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楊寧蓀、魏紋祈、黃郁婷、王倩俁 (2011) 維繫健康的抗病機制—免疫系統活化的秘密 科學月刊 42, 916-921.