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邱俊棠(Chiou, Chun-Tang)

邱俊棠生活照姓名 : 邱俊棠(Chiou, Chun-Tang)  
職稱 : 助理研究員  
電話 : 2820-19998091
E-mail : ctchiou@nricm.edu.tw

學歷:
國防醫學院 生命科學研究所 博士

主要經歷:
國立台灣大學醫學院 藥學系 博士後研究

專長:
細胞生物學,藥物篩選

研究簡介:
     癌症是全球死亡的主要原因。雖然有很多抗腫瘤藥物在臨床中的使用,現在,它們嚴重的副作用驅使我們發展新的治療策略,用以治療癌症、延長病人生命,和改善病人的生活品質。腫瘤細胞的形成主要是因為細胞生長失去應有的控制所引起,其原因主要可歸因於兩點:細胞週期檢查點失效以及細胞凋亡不活化。因此,活化細胞週期檢查點功能以及引發細胞凋亡是治療癌症的策略。我們已經建立一系列的技術來鑑定具有抗癌活性的中草藥成分或是化合物。這些技術包括快速的抗癌藥物篩選平台、抗癌機轉研究方法、以及荷瘤小鼠模型等。我們目前已經找到幾個具有抗癌活性的化合物,正在分析其作用機轉以及活體的抗癌活性確效。我們希望有朝一日能夠開發出有用的抗癌藥物,在對抗癌症上有一些貢獻。

期刊論文:

      NCBI PubMed :  Chun-Tang Chiou (Please click!!)

  1. Chiou, C.-T., Hsu, R.-Y., & Lin, L.-C. (2014). Isolation and cytotoxic effect of anthraquinones from Morinda umbellata. Planta Medica, 80(13), 1113-1117.  doi:10.1055/s-0034-1382956
  2. Chiou, C.-T., Kuo, Y.-H., Chan, Y.-Y., Juang, S.-H., Chan, H.-H., & Wu, T.-S. (2012). Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro. Phytochemistry, 80, 64-69. doi:10.1016/j.phytochem.2012.05.005
  3. Deore, R. R., Chen, G. S., Chang, P.-T., Chern, T.-R., Lai, S.-Y., Chuang, M.-H., . . . Chern, J.-W. (2012). Discovery of N-arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide derivatives as HCV NS5B polymerase inhibitors. ChemMedChem, 7(5), 850-860. doi:10.1002/cmdc.201200058
  4. Huang, H.-C., Chiou, C.-T., Hsiao, P.-C., Liaw, C.-C., Zhang, L.-J., Chang, C.-L., . . . Kuo, Y.-H. (2012). Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai. Molecules, 17(2), 1837-1851. doi:10.3390/molecules17021837
  5. Lee, Y.-H., Wei, C.-W., Wang, J.-J., & Chiou, C.-T. (2011). Rana catesbeiana ribonuclease inhibits Japanese encephalitis virus (JEV) replication and enhances apoptosis of JEV-infected BHK-21 cells. Antiviral Research, 89(3), 193-198.  doi:10.1016/j.antiviral.2011.01.002
  6. Zhang, L.J., Chiou, C.T., Cheng, J.J., Huang, H.C., Kuo, L.M., Liao, C.C., Bastow, K.F., Lee, K.H., Kuo, Y.H. (2010) Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica. J. Nat. Prod., 73:557–562.
  7. Chiou, C.T., Chen, G.S., Chen, M.L., Li, H., Shi, L., Huang, X.H., Dai, W.M., Chern, J.W.* (2010) Synthesis and anti-tumor mechanism study of N-(2-arylindol-7-yl)benzenesulfonamide derivatives. ChemMedChem, 5:1489–1497.
  8. Cheng, J.J., Zhang, L.J., Cheng, H.L., Chiou, C.T., Lee, I.J., Kuo, Y.H. (2010) Cytotoxic hexacyclic triterpene acids from Euscaphis japonica. J. Nat. Prod., 73:1655–1658.
  9. Lin, L.C., Chiou, C.T., Cheng, J.J. (2011) 5-Deoxyflavones with cytotoxic activity from Mimosa diplotricha. J. Nat. Prod., 74:2001–2004.
  10. Cheng, J. J., Zhang, L. J., Cheng, H. L., Chiou, C. T., Lee, I. J., and Kuo, Y. H. Cytotoxic hexacyclic triterpene acids from Euscaphis japonica. J. Nat. Prod. 73:1655–1658. [SCI]
  11. Chiou, C. T., Chen, G. S., Chen, M. L., Li, H., Shi, L., Huang, X. H., Dai, W. M., and Chern, J. W.* (2010). Synthesis and anti-tumor mechanism study of N-(2-arylindol-7-yl)benzenesulfonamide derivatives. ChemMedChem 5:1489-1497. [SCI]
  12. Zhang, L. J., Chiou, C. T., Cheng, J. J., Huang, H. C., Kuo, L. M., Liao, C. C., Bastow, K. F., Lee, K. H., and Kuo, Y. H. (2010). Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica. J. Nat. Prod. 73:557-562. [SCI]
  13. Chen, C, S., Chiou, C. T., Chen, G. S., S. C. Chen, C. Y. Hu, W. K. Chi, Y. D. Chu, L. H. Hwang, P. J. Chen, D. S. Chen, S. H. Liaw, and J. W. Chern. (2009). Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. J. Med. Chem. 52: 2716-2723. [SCI]
  14. Chiou, C. T., Hu, C. C. A., Chen, B. H., Liao, C. L., Lin, Y. L. and Wang, J. J. (2003). Association of Japanese encephalitis virus NS3 protein with microtubules and tumor susceptibility gene 101 (TSG101) protein. J. Gen. Virol. 84: 2795-2805. [SCI]
  15. Keng, N. T., Yin, F. Y., Chiou, C. T., Ratner, L. and Wang, J. J. (2003). Immunocytochemical evidence of the presence of CD4-Nef complexes on human T-cell surface enhances CD4 down-regulation. Chinese J. Infect. Dis. 21: 21-26.
  16. Chiou, C. T., Mai, R. T., Lam, C and Wang, J. J. (2002). Follicular dendritic cell damages with the expression of viral proteins in lymph nodes of HIV/AIDS patients. J. Med. Sci. 22: 109-118.
  17. Wang, J. J., Sandefur, S., Spearman, P., Chiou, C. T., Chiang, P. H. and Ratner, L. (2001). Tracking the assembly pathway of human immunodeficiency virus type 1 Gag deletion mutants by immunogold labeling. Appl. Immunohistochem. Mol. Morphol. 9: 371-379. [SCI]
  18. Chiou, C. T., Hu, H. M., Chuang, C. Y., Chen, Y. L., Liao, C. L., Chen, C. F., Gomez, V. F. and Wang, J. J. (2000). Detection of HIV proteins and genomes in lymph nodes of AIDS patients: evaluation of ELISA/Serodia assay for HIV serodiagnosis. J. Med. Sci. 20: 347-362.
  19. Wang, J. J., Liao, C. L., Yang, C. I., Chiou, C. T., and Chen, L. K. (1998). Localization of NS3 and E proteins in mouse brain infected with mutant strain of Japanese encephalitis virus. Arch. Virol. 143: 2353-2369. [SCI]
  20. Wang, J. J., Liao, C. L., Chiou, Y. W., Chiou, C. T., Huang, Y. L., and Chen, L. K. (1997). Ultrastructure and localization of E proteins in cultured neuron cells infected with Japanese encephalitis virus. Virology 238: 30-39. [SCI]
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